(Q37808484)

23 August 2017

title

Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance (English)

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23 August 2017

Hongbin Yu

1

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23 August 2017

Daniel Bischoff

series ordinal

2

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23 August 2017

Donald Tweedie

series ordinal

3

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23 August 2017

language of work or name

English

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publication date

11 November 2010

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Expert Opinion on Drug Metabolism & Toxicology

23 August 2017

published in

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23 August 2017

volume

6

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23 August 2017

issue

12

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23 August 2017

page(s)

1539-1549

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The significance of phase II (conjugation) reactions in drug disposition and toxicity

23 August 2017

cites work

1 reference

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Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment

21 January 2018

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Drug metabolites in safety testing

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In silico methods for predicting metabolism and mass fragmentation applied to quetiapine in liquid chromatography/time-of-flight mass spectrometry urine drug screening

21 January 2018

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Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials

21 January 2018

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Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

21 January 2018

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Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology

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Applying mechanisms of chemical toxicity to predict drug safety

21 January 2018

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Idiosyncratic drug reactions: past, present, and future

21 January 2018

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New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

21 January 2018

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The use of accelerator mass spectrometry to obtain early human ADME/PK data

21 January 2018

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Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

21 January 2018

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10.1517/17425255.2010.530655

21 January 2018

Identifiers

DOI

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23 August 2017

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