(Q37809078)

23 August 2017

title

Retinoids, retinoic acid receptors, and cancer (English)

1 reference

23 August 2017

Retinoids, Retinoic Acid Receptors, and Cancer (English)

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

25 August 2024

1 reference

Xiao-Han Tang

1

1 reference

23 August 2017

Lorraine J. Gudas

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21073338

25 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21073338

25 August 2024

publication date

1 January 2011

1 reference

full work available at URL

23 August 2017

http://arjournals.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130303

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21073338

https://www.annualreviews.org/doi/pdf/10.1146/annurev-pathol-011110-130303

25 August 2024

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Annual Review of Pathology: Mechanisms of Disease

25 August 2024

published in

1 reference

23 August 2017

volume

6

1 reference

23 August 2017

page(s)

345-364

1 reference

Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis

23 August 2017

cites work

1 reference

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Diverse actions of retinoid receptors in cancer prevention and treatment.

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Synthetic retinoids and their nuclear receptors

25 August 2024

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Mechanisms of digestion and absorption of dietary vitamin A.

25 August 2024

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ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production

25 August 2024

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A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

25 August 2024

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Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome to non-lethal anophthalmia

25 August 2024

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RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome

25 August 2024

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Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency

25 August 2024

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Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).

25 August 2024

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Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet

25 August 2024

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The molecular basis of retinoid absorption: a genetic dissection

25 August 2024

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Retinoic acid synthesis and signaling during early organogenesis

25 August 2024

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RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development

25 August 2024

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Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal

25 August 2024

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Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

25 August 2024

20

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

25 August 2024

21

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer

25 August 2024

22

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Retinol conversion to retinoic acid is impaired in breast cancer cell lines relative to normal cells

25 August 2024

23

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model

25 August 2024

24

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha

25 August 2024

25

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1.

25 August 2024

26

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Transcriptional activities of retinoic acid receptors

25 August 2024

27

1 reference

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Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6

25 August 2024

30

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis

25 August 2024

31

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

cis-acting DNA regulatory elements, including the retinoic acid response element, are required for tissue specific laminin B1 promoter/lacZ expression in transgenic mice

25 August 2024

32

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene

25 August 2024

33

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors

25 August 2024

34

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Deconstructing repression: evolving models of co-repressor action

25 August 2024

35

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Nuclear receptor coregulators in cancer biology

25 August 2024

36

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements

25 August 2024

37

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells

25 August 2024

38

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

25 August 2024

39

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro.

25 August 2024

40

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation

25 August 2024

41

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator

25 August 2024

42

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

25 August 2024

43

1 reference

https://api.crossref.org/works/10.1146/ANNUREV-PATHOL-011110-130303

Cell cycle, CDKs and cancer: a changing paradigm

25 August 2024

44

1 reference

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The targeted disruption of both alleles of RARbeta(2) in F9 cells results in the loss of retinoic acid-associated growth arrest.

25 August 2024

45

1 reference

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RAR and RXR modulation in cancer and metabolic disease

25 August 2024

47

1 reference

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Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells

25 August 2024

49

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HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition

25 August 2024

51

1 reference

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Tumor-suppressive activity of retinoic acid receptor-beta in cancer

25 August 2024

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25 August 2024

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Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.

25 August 2024

55

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Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism

25 August 2024

56

1 reference

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Nuclear cyclin D1: an oncogenic driver in human cancer

25 August 2024

57

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Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms

25 August 2024

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25 August 2024

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Retinoic acid-induced cell cycle arrest of human myeloid cell lines.

25 August 2024

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Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy

25 August 2024

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Growth Inhibition of a Human Myeloma Cell Line by All-transRetinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21WAF1

25 August 2024

64

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Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis

25 August 2024

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Growth inhibition of cultured human gastric cancer cells by 9-cis-retinoic acid with induction of cdk inhibitor Waf1/Cip1/Sdi1/p21 protein

25 August 2024

66

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p27/Kip1 mediates retinoic acid-induced suppression of ovarian carcinoma cell growth

25 August 2024

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Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2.

25 August 2024

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Expression profiles of Id1 and p16 proteins in all-trans-retinoic acid-induced apoptosis and cell cycle re-distribution in melanoma.

25 August 2024

70

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Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.

25 August 2024

71

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All-trans retinoic acid (atRA) differentially induces apoptosis in matched primary and metastatic melanoma cells -- a speculation on damage effect of atRA via mitochondrial dysfunction and cell cycle redistribution

25 August 2024

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Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.

25 August 2024

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Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation

25 August 2024

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Differentiating agents in pediatric malignancies: retinoids in neuroblastoma.

25 August 2024

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Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study

25 August 2024

79

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The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia.

25 August 2024

80

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The methyl-CpG binding protein MBD1 is required for PML-RARalpha function

25 August 2024

81

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

25 August 2024

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Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

25 August 2024

83

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

25 August 2024

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MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

25 August 2024

85

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PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia

25 August 2024

86

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A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes

25 August 2024

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Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells

25 August 2024

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Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia

25 August 2024

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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

25 August 2024

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Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

25 August 2024

91

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

25 August 2024

92

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Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure

25 August 2024

93

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RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells

25 August 2024

94

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Dominant negative retinoic acid receptor initiates tumor formation in mice

25 August 2024

96

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DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia

25 August 2024

97

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Retinoids in biological control and cancer

25 August 2024

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Nuclear retinoic acid receptor beta as a tool in chemoprevention trials

25 August 2024

99

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Quantitative RARbeta2 hypermethylation: a promising prostate cancer marker

25 August 2024

100

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Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells

25 August 2024

101

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The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling

25 August 2024

102

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The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells

25 August 2024

103

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MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

25 August 2024

105

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MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression

25 August 2024

106

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Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs

25 August 2024

107

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HACE1: A novel repressor of RAR transcriptional activity.

25 August 2024

108

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LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling

25 August 2024

109

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The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors

25 August 2024

110

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Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway

25 August 2024

111

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ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

25 August 2024

112

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Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance

25 August 2024

113

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Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.

25 August 2024

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25 August 2024

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Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer

25 August 2024

116

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Cancer stem cells: mirage or reality?

25 August 2024

117

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Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.

25 August 2024

118

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Human neuroblastoma stem cells

25 August 2024

119

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Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model

25 August 2024

120

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Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.

25 August 2024

121

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A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide

25 August 2024

122

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Histone deacetylase inhibitors regulate retinoic acid receptor beta expression in neuroblastoma cells by both transcriptional and posttranscriptional mechanisms

25 August 2024

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Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

25 August 2024

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Activity of interferon-alpha and isotretinoin in patients with advanced, refractory lymphoid malignancies

25 August 2024

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25 August 2024

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25 August 2024

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25 August 2024

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25 August 2024

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Identifiers

1 reference

23 August 2017

1 reference