(Q37810185)

23 August 2017

title

Metabolite quantitation: detector technology and MIST implications (English)

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23 August 2017

Pat Wright

1

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23 August 2017

Zhuang Miao

series ordinal

2

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23 August 2017

Barclay Shilliday

series ordinal

3

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23 August 2017

publication date

1 July 2009

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23 August 2017

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23 August 2017

volume

1

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23 August 2017

issue

4

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23 August 2017

page(s)

831-845

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Investigation of interaction between salmeterol and fluticasone propionate and its effect on quantitative accuracy of an LC/MS/MS assay in human plasma at low pg/mL concentrations

23 August 2017

cites work

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Fluorine-19 or phosphorus-31 NMR spectroscopy: a suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs

21 January 2018

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Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing

21 January 2018

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Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

21 January 2018

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Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.

21 January 2018

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Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism

21 January 2018

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Quantitation of drug metabolites in the absence of pure metabolite standards by high-performance liquid chromatography coupled with a chemiluminescence nitrogen detector and mass spectrometer

21 January 2018

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Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bond

21 January 2018

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Accelerating the drug optimization process: identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector

21 January 2018

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Liquid chromatography-mass spectrometry with chemiluminescent nitrogen detection for on-line quantitative analysis of compound collections: advantages and limitations

21 January 2018

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Bioanalytical applications of accelerator mass spectrometry for pharmaceutical research

21 January 2018

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Accelerator mass spectrometry in pharmaceutical research and development--a new ultrasensitive analytical method for isotope measurement

21 January 2018

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High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds

21 January 2018

1 reference

Sensitive sulphur-specific detection of omeprazole metabolites in rat urine by high-performance liquid chromatography/inductively coupled plasma mass spectrometry

21 January 2018

1 reference

Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.

21 January 2018

1 reference

Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine

21 January 2018

1 reference

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

21 January 2018

1 reference

Superheated water chromatography--a green technology for the future

21 January 2018

1 reference

Superheated water eluent capillary liquid chromatography

21 January 2018

1 reference

Superheated water as an eluent for reversed-phase high-performance liquid chromatography

21 January 2018

1 reference

On-line coupled superheated water extraction (SWE) and superheated water chromatography (SWC).

21 January 2018

1 reference

Flame ionization detection after splitting the water effluent in subcritical water chromatography.

21 January 2018

1 reference

Detector for liquid chromatography based on acoustic emissions from an oscillating flame

21 January 2018

1 reference

Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection.

21 January 2018

1 reference

In vitro and in vivo metabolisms of K-48.

21 January 2018

1 reference

In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist

21 January 2018

1 reference

A sensitive HPLC method for the determination of fluoxetine and norfluoxetine in human plasma with fluorescence detection

21 January 2018

1 reference

Electrochemical detection in bioanalysis

21 January 2018

1 reference

Comparison of HPLC with electrochemical detection and LC-MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma

21 January 2018

1 reference

Laser-based non-fluorescence detection techniques for liquid separation systems

21 January 2018

1 reference

Quantification of etoposide and etoposide phosphate in human plasma by micellar electrokinetic chromatography and near-field thermal lens detection

21 January 2018

1 reference

Indirect thermal lens detection for capillary electrophoresis

21 January 2018

1 reference

Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source

21 January 2018

1 reference

Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI?

21 January 2018

1 reference

Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response: standard-free quantitative estimation of metabolite levels in drug discovery

21 January 2018

1 reference

Response normalized liquid chromatography nanospray ionization mass spectrometry

21 January 2018

1 reference

Development and validation of a novel LC/ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals

21 January 2018

1 reference

Methodological modifications on quantification of phosphatidylethanol in blood from humans abusing alcohol, using high-performance liquid chromatography and evaporative light scattering detection

21 January 2018

1 reference

Comparison of universal detectors for high-temperature micro liquid chromatography

21 January 2018

1 reference

Corona discharge neutralizer for electrospray aerosols used with condensation nucleation light-scattering detection.

21 January 2018

1 reference

Condensation nucleation light scattering detection with ion chromatography for direct determination of glyphosate and its metabolite in water

21 January 2018

1 reference

Universal response in liquid chromatography using charged aerosol detection.

21 January 2018

1 reference

Corona-charged aerosol detection in supercritical fluid chromatography for pharmaceutical analysis.

21 January 2018

1 reference

Toward single-calibrant quantification in HPLC. A comparison of three detection strategies: evaporative light scattering, chemiluminescent nitrogen, and proton NMR.

21 January 2018

1 reference

LC-NMR-MS in drug discovery

21 January 2018

1 reference

Parahydrogen induced polarization of barbituric acid derivatives: 1H hyperpolarization studies

21 January 2018

1 reference

An algorithm for the automated quantitation of metabolites in in vitro NMR signals.

21 January 2018

1 reference

Quantitative metabolomics using NMR

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/BIO.09.63

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23 August 2017

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