(Q37810232)

23 August 2017

Addressing metabolite safety during first-in-man studies using ¹⁴C-labeled drug and accelerator mass spectrometry (English)

1 reference

23 August 2017

0 references

Graham Lappin

1

1 reference

PubMed ID

21083242

23 August 2017

Mark Seymour

series ordinal

2

1 reference

23 August 2017

1 July 2010

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23 August 2017

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23 August 2017

2

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23 August 2017

7

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23 August 2017

1315-1324

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Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism

23 August 2017

1 reference

Mechanisms of aflatoxin carcinogenesis

21 January 2018

1 reference

Role of metabolism in drug-induced idiosyncratic hepatotoxicity

21 January 2018

1 reference

Predicting circulating human metabolites: how good are we?

21 January 2018

1 reference

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing

21 January 2018

1 reference

Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

21 January 2018

1 reference

Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials

21 January 2018

1 reference

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.

21 January 2018

1 reference

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

21 January 2018

1 reference

Response normalized liquid chromatography nanospray ionization mass spectrometry

21 January 2018

1 reference

Bioanalytical applications of accelerator mass spectrometry for pharmaceutical research

21 January 2018

1 reference

Accelerator mass spectrometry best practices for accuracy and precision in bioanalytical (14)C measurements

21 January 2018

1 reference

Comparison of a 250 kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer--fitness for purpose in bioanalysis

21 January 2018

1 reference

Microdose clinical trial: quantitative determination of nicardipine and prediction of metabolites in human plasma

21 January 2018

1 reference

Calculation of isotope effects from first principles

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/BIO.10.87

1 reference

23 August 2017

1 reference

PubMed ID

21083242