(Q37815355)

23 August 2017

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title

The burden of obesity on infectious disease (English)

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23 August 2017

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1

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author name string

Melinda A Beck

series ordinal

2

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23 August 2017

publication date

1 December 2010

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Experimental Biology and Medicine

23 August 2017

published in

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23 August 2017

volume

235

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23 August 2017

issue

12

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23 August 2017

page(s)

1412-1424

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A war on obesity, not the obese.

23 August 2017

cites work

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Adipose tissue, adipokines, and inflammation

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Adipose tissue and the immune system

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Obesity and immune function relationships.

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The weight of leptin in immunity

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The obese surgical patient: a susceptible host for infection

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Obesity and infection

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Nosocomial infections and obesity in surgical patients

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Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

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The impact of obesity on surgical outcomes: a review

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Pulmonary complications of obesity

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Respiratory complications of obesity

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Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men

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A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women

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Obesity and site-specific nosocomial infection risk in the intensive care unit

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Discharge after discharge: predicting surgical site infections after patients leave hospital

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Percent body fat and prediction of surgical site infection

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Impact of obesity on outcomes after open surgical and endovascular abdominal aortic aneurysm repair

21 January 2018

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The prevalence of Helicobacter pylori in obese subjects

21 January 2018

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Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease.

21 January 2018

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Are natural killer cells protecting the metabolically healthy obese patient?

21 January 2018

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Obesity accelerates thymic aging

21 January 2018

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Obesity and immunocompetence

21 January 2018

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Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke

21 January 2018

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A role for leptin and its cognate receptor in hematopoiesis

21 January 2018

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Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

21 January 2018

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Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays

21 January 2018

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T lymphopenia in genetically obese-diabetic Wistar fatty rats: effects of body weight reduction on T cells

21 January 2018

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Energy restriction restores the impaired immune response in overweight (cafeteria) rats

21 January 2018

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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 January 2018

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Impairment of dendritic cell functionality and steady-state number in obese mice

21 January 2018

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Severe pulmonary metastasis in obese and diabetic mice

21 January 2018

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Long term effects of high fat and sucrose diets on obesity and lymphocyte proliferation in mice.

21 January 2018

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Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Animal model of Mycobacterium abscessus lung infection

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin receptor signaling is required for vaccine-induced protection against Helicobacter pylori.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Susceptibility of mice to group B coxsackie virus is influenced by the diabetic gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin deficiency enhances myocardial necrosis and lethality in a murine model of viral myocarditis

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis

21 January 2018

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Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Hepatitis B vaccine immunoresponsiveness in adolescents: a revaccination proposal after primary vaccination.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Immunogenicity of hepatitis B Vaccines. Implications for persons at occupational risk of hepatitis B virus infection

21 January 2018

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Hepatitis B vaccine responsiveness in Connecticut public safety personnel

21 January 2018

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Reduced tetanus antibody titers in overweight children

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

A role for leptin in sustaining lymphopoiesis and myelopoiesis

21 January 2018

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Seroconvertion to hepatitis B vaccine after weight reduction in obese non-responder

21 January 2018

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The precursors of memory: models and controversies.

21 January 2018

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Programming, demarcating, and manipulating CD8+ T-cell memory.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Primer: making sense of T-cell memory.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The persistence of T cell memory.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Diversity in T cell memory: an embarrassment of riches

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Development, trafficking, and function of memory T-cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The descent of memory T-cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Memory CD8+ T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Making sense of inflammation, epigenetics, and memory CD8+ T-cell differentiation in the context of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The Tower of Babel of CD8+ T-cell memory: known facts, deserted roads, muddy waters, and possible dead ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Homeostasis of memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Effector and memory CTL differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Shaping and reshaping CD8+ T-cell memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Promising new causal explanations for obesity and obesity-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Diet-induced obesity impairs the T cell memory response to influenza virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipose tissue: the new endocrine organ? A review article

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The emerging role of adipokines as mediators of inflammation and immune responses

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipokines: inflammation and the pleiotropic role of white adipose tissue

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipose tissue and its relation to inflammation: the role of adipokines

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipose tissue dysfunction in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipose tissue: a regulator of inflammation

21 January 2018

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Mechanisms of leptin action and leptin resistance

21 January 2018

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Leptin resistance and the response to positive energy balance

21 January 2018

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Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

21 January 2018

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Leptin, from fat to inflammation: old questions and new insights.

21 January 2018

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Leptin and the regulation of body weight in mammals

21 January 2018

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Minireview: the brain as a molecular target for diabetic therapy

21 January 2018

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ob gene mutations and human obesity

21 January 2018

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Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

21 January 2018

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Leptin receptor action and mechanisms of leptin resistance

21 January 2018

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Role of leptin in immunology

21 January 2018

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Leptin: nourishment for the immune system

21 January 2018

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Role of leptin in the activation of immune cells.

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin action in the thymus

21 January 2018

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21 January 2018

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Adipocytokines: mediators linking adipose tissue, inflammation and immunity

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The role of leptin in innate and adaptive immune responses

21 January 2018

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Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis

21 January 2018

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Leptin signaling: A key pathway in immune responses.

21 January 2018

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21 January 2018

Leptin and Inflammation

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Unraveling the multiple roles of leptin in inflammation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Anorexia of infection: current prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Signals generating anorexia during acute illness

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Elevated serum leptin concentrations induced by experimental acute inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The thymus is a common target in malnutrition and infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

CNS leptin action modulates immune response and survival in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Regulation of T lymphocyte metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The CD28 signaling pathway regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Revving the engine: signal transduction fuels T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Metabolism in T cell activation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The TOR pathway comes of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Genetic and environmental interactions in obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Reversal of diet-induced obesity and diabetes in C57BL/6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Recent advances in understanding leptin signaling and leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

DNA methylation and the expanding epigenetics of T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Methylation and demethylation in the regulation of genes, cells, and responses in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Epigenetics and T-cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Epigenetic regulation of cytokine gene expression in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Gene silencing quantitatively controls the function of a developmental trans-activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Impaired memory CD8 T cell development in the absence of methyl-CpG-binding domain protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Increases in Clinically Severe Obesity in the United States, 1986-2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Prevalence and trends in obesity among US adults, 1999-2008

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Effects of weight loss and exercise training on natural killer cell activity in obese women

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin regulation of the immune response and the immunodeficiency of malnutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Resistance of Janus kinase-2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The autocrine and paracrine roles of adipokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Resistin- and Obesity-associated metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Apelin, a novel adipokine over-produced in obesity: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Circulating omentin concentration increases after weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Omentin plasma levels and gene expression are decreased in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipsin and complement factor D activity: an immune-related defect in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

BAFF, APRIL and their receptors: structure, function and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Anti-inflammatory effects of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

The major inflammatory mediator interleukin-6 and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Alterations in T-Cell Subset Frequency in Peripheral Blood in Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2010.010227

21 January 2018

Identifiers

DOI

10.1258/EBM.2010.010227

1 reference

23 August 2017

1 reference