(Q37823358)

23 August 2017

1 reference

title

Biophysical alteration of the secretory track in β-cells due to molecular overcrowding: the relevance for diabetes (English)

1 reference

23 August 2017

author name string

Constantin Ionescu-Tirgoviste

series ordinal

1

1 reference

23 August 2017

Florin Despa

series ordinal

2

1 reference

23 August 2017

publication date

21 December 2010

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23 August 2017

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23 August 2017

volume

3

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23 August 2017

issue

3

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23 August 2017

page(s)

173-179

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Macromolecular crowding: an important but neglected aspect of the intracellular environment

23 August 2017

cites work

1 reference

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Molecular crowding enhances native state stability and refolding rates of globular proteins

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Molecular crowding effects on protein stability

21 January 2018

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Dilation of the endoplasmic reticulum in beta cells due to molecular overcrowding? Kinetic simulations of extension limits and consequences on proinsulin synthesis

21 January 2018

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Endoplasmic reticulum overcrowding as a mechanism of beta-cell dysfunction in diabetes

21 January 2018

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Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface.

21 January 2018

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Proinsulin maturation, misfolding, and proteotoxicity

21 January 2018

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Insulin gene mutations as a cause of permanent neonatal diabetes

21 January 2018

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Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted

21 January 2018

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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus

21 January 2018

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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells

21 January 2018

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Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

21 January 2018

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21 January 2018

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The origin of long-range attraction between hydrophobes in water

21 January 2018

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The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.

21 January 2018

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21 January 2018

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Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

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21 January 2018

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21 January 2018

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Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

21 January 2018

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

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21 January 2018

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21 January 2018

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The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

21 January 2018

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Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

21 January 2018

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Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

21 January 2018

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Effects of macromolecular crowding on protein folding and aggregation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

21 January 2018

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21 January 2018

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Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A higher proinsulin response to glucose loading predicts deteriorating fasting plasma glucose and worsening to diabetes in subjects with impaired glucose tolerance.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?

21 January 2018

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What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism

21 January 2018

1 reference

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Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus

21 January 2018

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Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes

21 January 2018

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IRIS II study: intact proinsulin is confirmed as a highly specific indicator for insulin resistance in a large cross-sectional study design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

Type 2 diabetes, insulin secretion and beta-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00029A

21 January 2018

Identifiers

DOI

10.1039/C0IB00029A

1 reference

23 August 2017

1 reference