(Q37826194)

23 August 2017

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title

CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease (English)

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23 August 2017

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Federica Borghese

1

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23 August 2017

Felix I L Clanchy

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

6 January 2011

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Expert Opinion on Therapeutic Targets

23 August 2017

published in

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23 August 2017

volume

15

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23 August 2017

issue

3

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23 August 2017

page(s)

237-251

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Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGs

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Mapping functional regions in the lumenal domain of the class II-associated invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Association of folding intermediates of glycoproteins with calnexin during protein maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Antigen presentation mediated by recycling of surface HLA-DR molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The chondroitin sulfate form of invariant chain trimerizes with conventional invariant chain and these complexes are rapidly transported from the trans-Golgi network to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Self-release of CLIP in peptide loading of HLA-DR molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

MHC II and the endocytic pathway: regulation by invariant chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

MHC class II molecules on the move for successful antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

21 January 2018

The p41 fragment story

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Surface activation of pro-cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The p41 isoform of invariant chain is a chaperone for cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain controls the activity of extracellular cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cathepsin S required for normal MHC class II peptide loading and germinal center development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74 is a member of the regulated intramembrane proteolysis-processed protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Proteolysis as a regulatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

MIF signal transduction initiated by binding to CD74

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Macrophage migration inhibitory factor: a regulator of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain induces B cell maturation by activating a TAF(II)105-NF-kappaB-dependent transcription program

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Differential expression of MHC class II antigens and cathepsin L by subtypes of cortical epithelial cells in the rat thymus: an immunoelectron microscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Association of the macrophage migration inhibitory factor gene polymorphisms with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The rheumatoid arthritis HLA-DRB1 shared epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

MHC class II-associated invariant chain isoforms regulate pulmonary immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Chemokine-like functions of MIF in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe-/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Expression of invariant chain and pro-cathepsin L in Alzheimer's brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74 interacts with APP and suppresses the production of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Essential role for macrophage migration inhibitory factor in gastritis induced by Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74 is a novel prognostic factor for patients with pancreatic cancer receiving multimodal therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Differential CD74 (major histocompatibility complex Class II invariant chain) expression in mouse and human intestinal adenomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74 is expressed by multiple myeloma and is a promising target for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Role for intracellular proteases in the processing and transport of class II HLA antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Invariant chain (CD74) gene regulation: enhanced expression associated with activation of protein kinase C delta in a murine B lymphoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Stabilization of invariant chain mRNA by 12-O-tetradecanoylphorbol-13-acetate is blocked by IFN-gamma in a murine B lymphoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNgamma-inducible Cd74 isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

CD74: a new candidate target for the immunotherapy of B-cell neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Milatuzumab - a promising new immunotherapeutic agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Up-regulation of vascular endothelial growth factor-D expression in clear cell renal cell carcinoma by CD74: a critical role in cancer cell tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cellular association and cytotoxicity of anti-CD74-targeted lipid drug-carriers in B lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

A functional heteromeric MIF receptor formed by CD74 and CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Inhibition of invariant chain processing, antigen-induced proliferative responses, and the development of collagen-induced arthritis and experimental autoimmune encephalomyelitis by a small molecule cysteine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Cathepsin S activity regulates antigen presentation and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The MHC class II-associated invariant chain-derived peptide clip binds to the peptide-binding groove of class II molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

C-terminal extension of the MHC class II-associated invariant chain by an antigenic sequence triggers activation of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Hijacking a chaperone: manipulation of the MHC class II presentation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Increasing the potency of MHC class II-presented epitopes by linkage to Ii-Key peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Results from a phase I clinical study of the novel Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine in patients with prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4+T-cell-independent CD8+T-cell-mediated tumor control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Involvement of macrophage migration inhibitory factor gene in celiac disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

Immunophenotypic identification of possible therapeutic targets in paediatric non-Hodgkin lymphomas: a children's oncology group report

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550879

10.1517/14728222.2011.550879

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference