(Q37833644)

24 August 2017

1 reference

title

Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages (English)

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24 August 2017

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John C Gensel

1

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24 August 2017

Dustin J Donnelly

series ordinal

2

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24 August 2017

Phillip G Popovich

series ordinal

3

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24 August 2017

language of work or name

English

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publication date

1 February 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

4

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24 August 2017

page(s)

505-518

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Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

The cellular inflammatory response in human spinal cords after injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Rewiring the injured CNS: lessons from the optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

A pro- and an anti-inflammatory cytokine are synthesised in distinct brain macrophage cells during innate activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Macrophages promote axon regeneration with concurrent neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Functional plasticity of macrophages: reversible adaptation to changing microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

High dose methylprednisolone in the management of acute spinal cord injury - a systematic review from a clinical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Neuroprotection and acute spinal cord injury: a reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline for short-term neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Erythropoietin in spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Does astrocytic glycogen benefit axon function and survival in CNS white matter during glucose deprivation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

The evidence for hypothermia as a neuroprotectant in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Clinical application of modest hypothermia after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Response of chemokine antagonists to inflammation in injured spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Effects of silica on the outcome from experimental spinal cord injury: implication of macrophages in secondary tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

High-dose methylprednisolone may do more harm for spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

End organ effects of high-dose human equivalent methylprednisolone in a spinal cord injury rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Nanoparticle-mediated local delivery of Methylprednisolone after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Neuroprotective effect of moderate epidural hypothermia after spinal cord injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Voltage-gated sodium channel blockers as immunomodulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Central nervous system regeneration inhibitors and their intracellular substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Disinhibition of neurite growth to repair the injured adult CNS: focusing on Nogo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Chondroitin sulphate proteoglycans in the CNS injury response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

How does chondroitinase promote functional recovery in the damaged CNS?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Novel roles for Nogo receptor in inflammation and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Myelin regulates immune cell adhesion and motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Overcoming macrophage-mediated axonal dieback following CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Rho GTPases as therapeutic targets for the treatment of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Prolonged lesional expression of RhoA and RhoB following spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Immune-based therapy for spinal cord repair: autologous macrophages and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

A phase 2 autologous cellular therapy trial in patients with acute, complete spinal cord injury: pragmatics, recruitment, and demographics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Autologous olfactory ensheathing cell transplantation in human spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Stem cells: Current approach and future prospects in spinal cord injury repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Chinese network to start trials of spinal surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

China Spinal Cord Injury Network: changes from within

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Patients warned about unproven spinal surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Fetal-cell therapy: paper chase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Embryonic stem cells promote motor recovery and affect inflammatory cell infiltration in spinal cord injured mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Spinal cord injury and neural repair: focus on neuroregenerative approaches for spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal Root Entry Zone in the Mammalian Spinal Cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.553605

10.1517/14728222.2011.553605

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference