(Q37850997)

24 August 2017

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title

Advances in osteoclast biology: old findings and new insights from mouse models (English)

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24 August 2017

James R Edwards

1

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24 August 2017

Gregory R Mundy

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

8 March 2011

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Nature Reviews Rheumatology

24 August 2017

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24 August 2017

7

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24 August 2017

235-243

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24 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.23

24 August 2017

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Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

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The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts

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Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.

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c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

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Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

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Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

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TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor

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Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

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FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

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Requirement for NF-kappaB in osteoclast and B-cell development

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NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis

31 March 2020

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

31 March 2020

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Limb and skin abnormalities in mice lacking IKKalpha

31 March 2020

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IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

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The transcription factor NF-ATc is essential for cardiac valve formation

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Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

31 March 2020

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Calcineurin/NFAT signaling in osteoblasts regulates bone mass

31 March 2020

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Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

31 March 2020

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.

31 March 2020

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Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

31 March 2020

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B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo

31 March 2020

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

31 March 2020

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Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo

31 March 2020

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Perspectives: Osteoclast adhesion and resorption: The role of podosomes

31 March 2020

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Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

31 March 2020

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

31 March 2020

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Ion channels and transporters in osteoclasts

31 March 2020

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Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.

31 March 2020

1 reference

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The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis

31 March 2020

1 reference

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Novel mutations in the a3 subunit of vacuolar H(+)-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Genetic regulation of osteoclast development and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Human carbonic anhydrases and carbonic anhydrase deficiencies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Long-term use of bisphosphonates in osteoporosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Denosumab in postmenopausal women with low bone mineral density

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.23

The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice

31 March 2020

1 reference

12 December 2020

Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption.

1 reference

12 December 2020

How the osteoclast degrades bone

1 reference

12 December 2020

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter

1 reference

12 December 2020

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors.

1 reference

12 December 2020

Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2011.23

1 reference

Dimensions Publication ID

24 August 2017

0 references

1 reference