(Q37851522)

24 August 2017

1 reference

title

Targeting interleukin-21 in inflammatory diseases (English)

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24 August 2017

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Massimiliano Sarra

1

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24 August 2017

Eleonora Franzè

series ordinal

2

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24 August 2017

Francesco Pallone

series ordinal

3

1 reference

24 August 2017

Giovanni Monteleone

series ordinal

4

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24 August 2017

language of work or name

English

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publication date

11 March 2011

1 reference

Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

6

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24 August 2017

page(s)

695-702

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A fundamental role for interleukin-21 in the generation of T follicular helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21 as a new therapeutic target for immune-mediated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Calcium-dependent activation of interleukin-21 gene expression in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

The molecular basis of IL-21-mediated proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Regulation of gut inflammation and th17 cell response by interleukin-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Immunopathogenesis and role of T cells in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

B cells in human and murine systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

T- and B-cell abnormalities in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A polymorphism within IL21R confers risk for systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A critical role for IL-21 in regulating immunoglobulin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Lessons from BXSB and related mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

IL-21 is required to control chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561319

10.1517/14728222.2011.561319

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference