(Q37858880)

24 August 2017

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title

The role of asymmetric and symmetric dimethylarginines in renal disease (English)

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24 August 2017

Edzard Schwedhelm

1

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24 August 2017

Rainer H Böger

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

29 March 2011

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Nature Reviews Nephrology

24 August 2017

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24 August 2017

7

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24 August 2017

5

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24 August 2017

275-285

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https://scigraph.springernature.com/pub.10.1038/nrneph.2011.31

24 August 2017

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cites work

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HPLC analysis of asymmetric dimethylarginine (ADMA) and related arginine metabolites in human plasma using a novel non-endogenous internal standard

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A critical review and discussion of analytical methods in the L-arginine/nitric oxide area of basic and clinical research

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Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects

21 January 2018

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Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities

21 January 2018

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Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltransferases

21 January 2018

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The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation

21 January 2018

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Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase

21 January 2018

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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

21 January 2018

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Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production

21 January 2018

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A methyl transferase links the circadian clock to the regulation of alternative splicing

21 January 2018

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Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

21 January 2018

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Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis

21 January 2018

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LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia

21 January 2018

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Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans

21 January 2018

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Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.

21 January 2018

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Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia

21 January 2018

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ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins

21 January 2018

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Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia

21 January 2018

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Purification and characterization of the constitutive nitric oxide synthase from human placenta

21 January 2018

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Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis

21 January 2018

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Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence

21 January 2018

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Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.

21 January 2018

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Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice

21 January 2018

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Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine

21 January 2018

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Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke

21 January 2018

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Extensive characterization of the human DDAH1 transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Disruption of methylarginine metabolism impairs vascular homeostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease - possible candidates for paradoxical epidemiology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Cardiovascular and sympathetic effects of nitric oxide inhibition at rest and during static exercise in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Impact of asymmetric dimethylarginine on mortality after acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in de

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in patients with chronic kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Methylated arginine derivatives in children and adolescents with chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Levels of dimethylarginines and cytokines in mild and severe preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and all-cause mortality in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

No Benefit of Hemodiafiltration over Hemodialysis in Lowering Elevated Levels of Asymmetric Dimethylarginine in ESRD Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

RNA and protein interactions modulated by protein arginine methylation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Effects of combined supplementation with B vitamins and antioxidants on plasma levels of asymmetric dimethylarginine (ADMA) in subjects with elevated risk for cardiovascular disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Dietary l -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Endogenous nitric oxide synthase inhibitors are responsible for the L -arginine paradox

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma membrane transporters for arginine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Haplotypic association of DDAH1 with susceptibility to pre-eclampsia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Atherosclerotic renal artery stenosis: epidemiology, cardiovascular outcomes, and clinical prediction rules.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

NO modulates norepinephrine release in human skeletal muscle: implications for neural preconditioning

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Response of Asymmetric Dimethylarginine to Hemodialysis-Associated Hypotension in End-Stage Renal Disease Patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Effects of amlodipine and valsartan on oxidative stress and plasma methylarginines in end-stage renal disease patients on hemodialysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Nitric oxide synthase inhibitors and hypertension in children and adolescents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Accumulation of symmetric dimethylarginine in hepatorenal syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2011.31

Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease.

31 March 2020

1 reference

12 December 2020

Isolation and Identification of N,N- and N,N' -Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human Urine

1 reference

12 December 2020

Methylation of arginine and lysine residues of cerebral proteins

1 reference

12 December 2020

Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay

1 reference

12 December 2020

Quantification of ADMA: analytical approaches

1 reference

12 December 2020

Protein Methylation: Chemical, Enzymological, and Biological Significance

1 reference

12 December 2020

Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.

1 reference

12 December 2020

Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding

1 reference

12 December 2020

NG, NG-dimethylarginine and NG, NG-dimethylarginine in renal insufficiency

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2011.31

1 reference

Dimensions Publication ID

24 August 2017

0 references

1 reference