(Q37860342)

24 August 2017

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title

The development of pyrrolobenzodiazepines as antitumour agents (English)

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24 August 2017

John A Hartley

1

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24 August 2017

language of work or name

English

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publication date

4 April 2011

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Expert Opinion on Investigational Drugs

24 August 2017

published in

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24 August 2017

volume

20

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24 August 2017

issue

6

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24 August 2017

page(s)

733-744

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Isolation and Characterization of Anthramycin, a New Antitumor Antibiotic

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

21 January 2018

1 reference

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Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

21 January 2018

1 reference

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Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis of novel C2 and C2–C8 linked pyrrolo[2,1- c ][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

21 January 2018

1 reference

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Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates

21 January 2018

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Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs.

21 January 2018

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DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent

21 January 2018

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Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.

21 January 2018

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DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

21 January 2018

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DNA binding properties of a new class of linked anthramycin analogs

21 January 2018

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Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents

21 January 2018

1 reference

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Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

DNA adducts from chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Relationships between functionality and genetic toxicology of selected DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

DNA interstrand crosslink repair in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

DNA interstrand cross-link repair in the cell cycle: a critical role for polymerase zeta in G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Pyrrolo[2,1-c][1,4]benzodiazepine-beta-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Antibody-drug conjugates: targeted drug delivery for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

CD20-specific antibody-targeted chemotherapy of non-Hodgkin’s B-cell lymphoma using calicheamicin-conjugated rituximab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

LC–MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.573477

10.1517/13543784.2011.573477

21 January 2018

Identifiers

DOI

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24 August 2017

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