(Q37862578)

24 August 2017

1 reference

title

p63, a story of mice and men. (English)

1 reference

24 August 2017

Hans Vanbokhoven

1

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24 August 2017

Gerry Melino

series ordinal

2

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24 August 2017

Eleonora Candi

series ordinal

3

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24 August 2017

Wim Declercq

series ordinal

4

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24 August 2017

language of work or name

English

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publication date

7 April 2011

1 reference

Journal of Investigative Dermatology

24 August 2017

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24 August 2017

131

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24 August 2017

1196-1207

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24 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/jid.2011.84

24 August 2017

0 references

cites work

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

TP63 gene mutation in ADULT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Epidermal homeostasis: a balancing act of stem cells in the skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

https://api.crossref.org/works/10.1038%2FJID.2011.84

1 reference

7 January 2021

TAp63 and DeltaNp63 in cancer and epidermal development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 is upstream of IKK alpha in epidermal development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Patterning mechanisms controlling vertebrate limb development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 regulates an adhesion programme and cell survival in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

DeltaNp63 plays an anti-apoptotic role in ventral bladder development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Expression of GATA-3 in epidermis and hair follicle: relationship to p63

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Terminal deletion of the long arm of chromosome 3 [46,XX,del(3)(q27-->qter)].

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

ΔNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Rapp-Hodgkin and Hay-Wells ectodermal dysplasia syndromes represent a variable spectrum of the same genetic disorder

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p53-family proteins and their regulators: hubs and spokes in tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 in epithelial survival, germ cell surveillance, and neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 short isoforms are found in invasive carcinomas only and not in benign breast conditions

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 and p73 in human cancer: defining the network

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Rapp-Hodgkin and AEC syndromes due to a new frameshift mutation in the TP63 gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Pathogenesis of split-hand/split-foot malformation.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Fine mapping of the X-linked split-hand/split-foot malformation (SHFM2) locus to a 5.1-Mb region on Xq26.3 and analysis of candidate genes.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

The roles of p63 in cancer

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 and IRF6: brothers in arms against cleft palate

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

TAp63 induces senescence and suppresses tumorigenesis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Perp is a p63-regulated gene essential for epithelial integrity.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Rationale and background as basis for a new classification of the ectodermal dysplasias

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Rapp-Hodgkin ectodermal dysplasia syndrome: the clinical and molecular overlap with Hay-Wells syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

GATA-3: an unexpected regulator of cell lineage determination in skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 induces key target genes required for epidermal morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Conflicting roles for p63 in skin development and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 is the molecular switch for initiation of an epithelial stratification program

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

DeltaNp63 knockdown mice: A mouse model for AEC syndrome

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Differential expression of p63 isoforms in female reproductive organs

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

miR-203 represses 'stemness' by repressing DeltaNp63

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A mutation of the p63 gene in non-syndromic cleft lip.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 and p73 transcriptionally regulate genes involved in DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A role for the mesenchymal T-box gene Brachyury in AER formation during limb development.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 null mutation protects mouse oocytes from radio-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Identification and functional characterization of two new transcriptional variants of the human p63 gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

DeltaNp63 is essential for epidermal commitment of embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 in skin appendage development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Treasure or artifact: a decade of p63 research speaks for itself.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Conditional inactivation of p63 by Cre-mediated excision

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 is a p53 homologue required for limb and epidermal morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Mutant p53 drives invasion by promoting integrin recycling

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Differential recognition of response elements determines target gene specificity for p53 and p63

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Transcriptional programs regulated by p63 in normal epithelium and tumors

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A 9.3 Mb microdeletion of 3q27.3q29 associated with psychomotor and growth delay, tricuspid valve dysplasia and bifid thumb

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Transcriptional network of p63 in human keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

The skin: an indispensable barrier

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63-associated disorders.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Cloning and characterization of two members of the vertebrate Dlx gene family

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Regulation of p53 family members by the ubiquitin-like SUMO system

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

TAp63 prevents premature aging by promoting adult stem cell maintenance

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 protects the female germ line during meiotic arrest

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Identification of new p63 targets in human keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

New p63 targets in keratinocytes identified by a genome-wide approach.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

A skin microRNA promotes differentiation by repressing 'stemness'.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.84

7 January 2021

Identifiers

DOI

10.1038/JID.2011.84

1 reference

24 August 2017

1 reference