(Q37862986)

24 August 2017

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title

Design principles of adaptive immune systems (English)

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24 August 2017

Thomas Boehm

1

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24 August 2017

8 April 2011

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Nature Reviews Immunology

24 August 2017

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24 August 2017

11

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24 August 2017

5

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24 August 2017

307-317

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microRNAs reveal the interrelationships of hagfish, lampreys, and gnathostomes and the nature of the ancestral vertebrate

24 August 2017

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Early jawless vertebrates and cyclostome origins

21 January 2018

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THE EVOLUTION OF THE IMMUNE RESPONSE. 3. IMMUNOLOGIC RESPONSES IN THE LAMPREY

21 January 2018

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Isolation and characterization of lymphocyte-like cells from a lamprey

21 January 2018

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Dual nature of the adaptive immune system in lampreys

21 January 2018

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Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

21 January 2018

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The evolution of adaptive immune systems

21 January 2018

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Meeting the demand for innate and adaptive immunities during evolution

21 January 2018

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Origin and evolution of the adaptive immune system: genetic events and selective pressures

21 January 2018

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Alternative adaptive immunity in jawless vertebrates

21 January 2018

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The origins of vertebrate adaptive immunity

21 January 2018

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THE EVOLUTION OF ADAPTIVE IMMUNITY

21 January 2018

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Recognition of additional roles for immunoglobulin domains in immune function

21 January 2018

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Evolution of innate and adaptive immunity: can we draw a line?

21 January 2018

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Regulation of adaptive immunity by the innate immune system

21 January 2018

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Alternative mechanisms of immune receptor diversity

21 January 2018

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Genomic insights into the immune system of the sea urchin

21 January 2018

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A thymus candidate in lampreys.

21 January 2018

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Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate

21 January 2018

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Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice.

21 January 2018

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Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase

21 January 2018

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Identification of a third variable lymphocyte receptor in the lamprey.

21 January 2018

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Variable lymphocyte receptors in hagfish

21 January 2018

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Transcriptional regulation of lymphocyte development

21 January 2018

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From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment

21 January 2018

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Multilayered specification of the T-cell lineage fate

21 January 2018

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21 January 2018

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A shared gene-expression signature in innate-like lymphocytes

21 January 2018

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Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential

21 January 2018

1 reference

Conserved functions of Ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish

21 January 2018

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IgT, a primitive immunoglobulin class specialized in mucosal immunity

21 January 2018

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Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint

21 January 2018

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Regulation of antigen-receptor gene assembly in hagfish

21 January 2018

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Memory-like responses of natural killer cells

21 January 2018

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Current perspectives of natural killer cell education by MHC class I molecules

21 January 2018

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Regulation of the natural killer cell receptor repertoire

21 January 2018

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Immune memory redefined: characterizing the longevity of natural killer cells

21 January 2018

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The evolutionary significance of ancient genome duplications

21 January 2018

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Expansion of signaling genes for adaptive immune system evolution in early vertebrates

21 January 2018

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The evolutionary history of lymphoid organs

21 January 2018

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A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy

21 January 2018

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The primitive immune system of amphioxus provides insights into the ancestral structure of the vertebrate immune system

21 January 2018

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The starfish axial organ: an ancestral lymphoid organ

21 January 2018

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T-cell antigen receptor genes and T-cell recognition

21 January 2018

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Sequences at the somatic recombination sites of immunoglobulin light-chain genes

21 January 2018

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Antibody responses of variable lymphocyte receptors in the lamprey.

21 January 2018

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Structure and specificity of lamprey monoclonal antibodies.

21 January 2018

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Allelic exclusion of immunoglobulin genes: models and mechanisms

21 January 2018

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Mechanics of T cell receptor gene rearrangement

21 January 2018

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Evolution of the immunoglobulin heavy chain class switch recombination mechanism

21 January 2018

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Molecular mechanisms of antibody somatic hypermutation.

21 January 2018

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Diversification of Ig superfamily genes in an invertebrate

21 January 2018

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Diverse functions for DNA and RNA editing in the immune system.

21 January 2018

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Sp185/333: a novel family of genes and proteins involved in the purple sea urchin immune response

21 January 2018

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High-affinity lamprey VLRA and VLRB monoclonal antibodies

21 January 2018

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Quantitative impact of thymic clonal deletion on the T cell repertoire

21 January 2018

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Predominant autoantibody production by early human B cell precursors

21 January 2018

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Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark

21 January 2018

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alpha, beta, gamma, and delta T cell antigen receptor genes arose early in vertebrate phylogeny.

21 January 2018

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Immunoglobulin heavy chain exclusion in the shark

21 January 2018

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T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis

21 January 2018

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PI3 kinase signals BCR-dependent mature B cell survival

21 January 2018

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Generating intrathymic microenvironments to establish T-cell tolerance.

21 January 2018

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Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

21 January 2018

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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

21 January 2018

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On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands

21 January 2018

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The evolution of vertebrate antigen receptors: a phylogenetic approach

21 January 2018

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A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

21 January 2018

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Positive selection of T cells, an in vitro view.

21 January 2018

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Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

21 January 2018

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A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire

21 January 2018

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Negative selection--clearing out the bad apples from the T-cell repertoire

21 January 2018

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How thymic antigen presenting cells sample the body's self-antigens

21 January 2018

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Control of regulatory T cell lineage commitment and maintenance

21 January 2018

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Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates.

21 January 2018

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Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage

21 January 2018

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Two genetically separable steps in the differentiation of thymic epithelium.

21 January 2018

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The descent of the antibody-based immune system by gradual evolution

21 January 2018

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Quality control in self/nonself discrimination

21 January 2018

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Invertebrate allorecognition: the origins of histocompatibility

21 January 2018

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Molecular mechanisms of allorecognition in a basal chordate

21 January 2018

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Model systems of invertebrate allorecognition.

21 January 2018

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Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus

21 January 2018

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Epigenetic control of Tcrb gene rearrangement.

21 January 2018

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The MHC molecules of nonmammalian vertebrates

21 January 2018

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Co-evolution of a primordial peptide-presentation system and cellular immunity

21 January 2018

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MHC class I peptides as chemosensory signals in the vomeronasal organ.

21 January 2018

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Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides.

21 January 2018

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Mate choice decisions of stickleback females predictably modified by MHC peptide ligands

21 January 2018

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Structures of TLR-ligand complexes

21 January 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

1 reference

Antigen Recognition by Variable Lymphocyte Receptors

21 January 2018

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Structural diversity of the hagfish variable lymphocyte receptors

21 January 2018

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The known unknowns of antigen processing and presentation.

21 January 2018

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How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

Shark immunity bites back: affinity maturation and memory response in the nurse shark,Ginglymostoma cirratum

21 January 2018

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Delineation of the Thymic and Bursal Lymphoid Systems in the Chicken

21 January 2018

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How did our complex immune system evolve?

21 January 2018

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Determining γδ versus αß T cell development.

31 March 2020

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Chemokines define distinct microenvironments in the developing thymus

31 March 2020

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Formation of the chicken B-cell repertoire: ontogenesis, regulation of Ig gene rearrangement, and diversification by gene conversion

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21475308

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytochemical properties of Botryllus schlosseri haemocytes: indications for morpho-functional characterisation.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21475308

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2944

1 reference

24 August 2017

1 reference

PubMed ID

21475308