(Q37863609)

24 August 2017

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title

Aggregates in monoclonal antibody manufacturing processes (English)

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24 August 2017

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María Vázquez-Rey

1

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24 August 2017

Dietmar A Lang

series ordinal

2

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24 August 2017

publication date

20 April 2011

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Biotechnology and Bioengineering

24 August 2017

published in

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24 August 2017

volume

108

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24 August 2017

issue

7

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24 August 2017

page(s)

1494-1508

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A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding.

24 August 2017

cites work

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Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations.

21 January 2018

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Aggregation of a monoclonal antibody induced by adsorption to stainless steel

21 January 2018

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Response of a concentrated monoclonal antibody formulation to high shear

21 January 2018

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Protein stability during freezing: separation of stresses and mechanisms of protein stabilization

21 January 2018

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21 January 2018

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Characterization of antibody aggregation: role of buried, unpaired cysteines in particle formation

21 January 2018

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An infrared spectroscopic study of the interactions of carbohydrates with dried proteins

21 January 2018

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Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

21 January 2018

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Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

21 January 2018

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Protein aggregation and bioprocessing

21 January 2018

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Effect of freezing on aggregation of human growth hormone

21 January 2018

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Industrial purification of pharmaceutical antibodies: development, operation, and validation of chromatography processes

21 January 2018

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Influence of osmolarity and pH increase to achieve a reduction of monoclonal antibodies aggregates in a production process

21 January 2018

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Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity

21 January 2018

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IgG aggregate removal by charged-hydrophobic mixed mode chromatography

21 January 2018

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Monoclonal antibody purification with hydroxyapatite

21 January 2018

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Self-buffering antibody formulations

21 January 2018

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Effect of lobe pumping on human albumin: development of a lobe pump simulator using smoothed particle hydrodynamics.

21 January 2018

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Type I 'antifreeze' proteins. Structure-activity studies and mechanisms of ice growth inhibition.

21 January 2018

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An exclusion mechanism in ion exchange chromatography

21 January 2018

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Virus inactivation by solvent/detergent treatment and the manufacture of SD-plasma

21 January 2018

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Adsorption characteristics of various proteins to a titanium surface

21 January 2018

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A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma

21 January 2018

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Protein aggregation in vitro and in vivo: a quantitative model of the kinetic competition between folding and aggregation

21 January 2018

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Equilibrium studies of protein aggregates and homogeneous nucleation in protein formulation.

21 January 2018

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Isolation of Stable Aggregates of IgG by Zonal Ultracentrifugation in Sucrose Gradients Containing Albumin

21 January 2018

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Current and future issues in the manufacturing and development of monoclonal antibodies

21 January 2018

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High-throughput screening of chromatographic separations: II. Hydrophobic interaction

21 January 2018

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The stability factor: importance in formulation development

21 January 2018

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Particulate matter contamination of intravenous antibiotics aggravates loss of functional capillary density in postischemic striated muscle

21 January 2018

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Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

21 January 2018

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Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process

21 January 2018

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A mesoscopic model for protein-protein interactions in solution

21 January 2018

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Protein aggregation: pathways, induction factors and analysis

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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Albumin denaturation during ultrafiltration: effects of operating conditions and consequences on membrane fouling

21 January 2018

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Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor

21 January 2018

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Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

21 January 2018

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The effect of shear on globular proteins during ultrafiltration: Studies of alcohol dehydrogenase

21 January 2018

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Is any measurement method optimal for all aggregate sizes and types?

21 January 2018

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Lyophilization-induced protein denaturation in phosphate buffer systems: monomeric and tetrameric beta-galactosidase

21 January 2018

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The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration".

21 January 2018

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Roadmap for implementation of quality by design (QbD) for biotechnology products

21 January 2018

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Quality by design for biopharmaceuticals

21 January 2018

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Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate.

21 January 2018

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Non-native protein aggregation kinetics

21 January 2018

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Effects of protein aggregates: an immunologic perspective

21 January 2018

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Protein kinetic stability.

21 January 2018

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mAbs: a business perspective

21 January 2018

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Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin

21 January 2018

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Immunogenicity of therapeutic proteins. Part 3: impact of manufacturing changes

21 January 2018

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Challenges in the development of high protein concentration formulations

21 January 2018

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Downstream processing of monoclonal antibodies--application of platform approaches

21 January 2018

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Impact of product-related factors on immunogenicity of biotherapeutics

21 January 2018

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Beyond water activity: Recent advances based on an alternative approach to the assessment of food quality and safety

21 January 2018

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Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces

21 January 2018

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Mechanism of insulin aggregation and stabilization in agitated aqueous solutions

21 January 2018

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Proteins in frozen solutions: evidence of ice-induced partial unfolding

21 January 2018

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Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution

21 January 2018

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Effects of shear on proteins in solution

21 January 2018

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Inverse relationship of protein concentration and aggregation.

21 January 2018

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Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice.

21 January 2018

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Membrane separations in biotechnology

21 January 2018

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Linear scale ultrafiltration

21 January 2018

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The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

21 January 2018

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Separation of monoclonal antibody alemtuzumab monomer and dimers using ultrafiltration.

21 January 2018

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Protein aggregation and its inhibition in biopharmaceutics

21 January 2018

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Non-size-based membrane chromatographic separation and analysis of monoclonal antibody aggregates

21 January 2018

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Antibody structure, instability, and formulation

21 January 2018

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Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

21 January 2018

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Pore size distributions of ion exchangers and relation to protein binding capacity

21 January 2018

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Exploitation of the adsorptive properties of depth filters for host cell protein removal during monoclonal antibody purification.

21 January 2018

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Pharmaceutical quality by design: product and process development, understanding, and control

21 January 2018

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Protein aggregation during overexpression limited by peptide extensions with large net negative charge.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.23155

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24 August 2017

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