(Q37865969)

24 August 2017

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title

Mechanisms of T-box gene function in the developing heart (English)

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24 August 2017

Franziska Greulich

1

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24 August 2017

Carsten Rudat

series ordinal

2

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24 August 2017

Andreas Kispert

series ordinal

3

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24 August 2017

publication date

14 April 2011

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24 August 2017

published in

Cardiovascular Research

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24 August 2017

volume

91

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24 August 2017

issue

2

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24 August 2017

page(s)

212-222

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Making or breaking the heart: from lineage determination to morphogenesis

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

How to make a heart: the origin and regulation of cardiac progenitor cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-targets: clues to understanding the functions of T-box proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Protein interactions at the heart of cardiac chamber formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box genes in vertebrate development

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box genes and heart development: putting the "T" in heart.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box factors determine cardiac design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box transcription factors and their roles in regulatory hierarchies in the developing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Signaling pathways controlling second heart field development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Ash2l interacts with Tbx1 and is required during early embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Retracted: Tbx1 Regulates the BMP-Smad1 Pathway in a Transcription Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

A myocardial lineage derives from Tbx18 epicardial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cloning and expression analysis of the mouse T-box gene Tbx18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx18 and the fate of epicardial progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx5specifies the left/right ventricles and ventricular septum position during cardiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

TBX5 nuclear localization is mediated by dual cooperative intramolecular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

LMP4 regulates Tbx5 protein subcellular localization and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Physical interaction between TBX5 and MEF2C is required for early heart development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cloning and expression analysis of the mouse T-box gene tbx20

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Differential expression and function of Tbx5 and Tbx20 in cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

The BMP pathway acts to directly regulate Tbx20 in the developing heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Characterization of TBX20 in human hearts and its regulation by TFAP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx3 is required for outflow tract development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

TBX3 and its splice variant TBX3 + exon 2a are functionally similar.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR112

21 January 2018

Identifiers

DOI

10.1093/CVR/CVR112

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24 August 2017

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