(Q37866316)

24 August 2017

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title

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer (English)

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24 August 2017

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Simon Staubach

1

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PubMed ID

21501018

24 August 2017

Franz-Georg Hanisch

series ordinal

2

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24 August 2017

1 April 2011

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Expert Review of Proteomics

24 August 2017

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24 August 2017

8

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24 August 2017

2

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24 August 2017

263-277

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Lipid rafts as a membrane-organizing principle

24 August 2017

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Triton promotes domain formation in lipid raft mixtures

21 January 2018

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The SPFH domain-containing proteins: more than lipid raft markers

21 January 2018

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The reggie/flotillin connection to growth

21 January 2018

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Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.

21 January 2018

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Regulation of raft-dependent endocytosis

21 January 2018

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GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.

21 January 2018

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MUC1 membrane trafficking is modulated by multiple interactions

21 January 2018

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Recycling of MUC1 is dependent on its palmitoylation.

21 January 2018

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Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles

21 January 2018

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Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells

21 January 2018

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G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains.

21 January 2018

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Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

21 January 2018

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Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton

21 January 2018

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Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton

21 January 2018

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Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target

21 January 2018

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Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization

21 January 2018

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Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1

21 January 2018

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CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells

21 January 2018

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Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion

21 January 2018

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A role for caveolae in cell migration.

21 January 2018

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Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

21 January 2018

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Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib

21 January 2018

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Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic

21 January 2018

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The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes

21 January 2018

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Fyn: a novel molecular target in cancer

21 January 2018

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Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src)

21 January 2018

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Structure and regulation of Src family kinases

21 January 2018

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Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells

21 January 2018

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Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function

21 January 2018

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Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

21 January 2018

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The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock

21 January 2018

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Hsp90 as a therapeutic target in patients with oesophageal carcinoma

21 January 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

21 January 2018

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Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.

21 January 2018

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Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

21 January 2018

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HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway

21 January 2018

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Hsp60 is actively secreted by human tumor cells

21 January 2018

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Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma

21 January 2018

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Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

21 January 2018

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Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

21 January 2018

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Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication

21 January 2018

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Skp2B attenuates p53 function by inhibiting prohibitin

21 January 2018

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Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins.

21 January 2018

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Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.

21 January 2018

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Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

21 January 2018

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A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses

21 January 2018

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The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction

21 January 2018

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Emerging themes in lipid rafts and caveolae.

21 January 2018

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Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation

21 January 2018

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

21 January 2018

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Cellular prion protein and caveolin-1 interaction in a neuronal cell line precedes Fyn/Erk 1/2 signal transduction.

21 January 2018

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Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.

21 January 2018

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Caveolin-1 in oncogenic transformation, cancer, and metastasis

21 January 2018

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Reduction of caveolin and caveolae in oncogenically transformed cells

21 January 2018

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Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

21 January 2018

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Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31).

21 January 2018

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Caveolae as organizers of pharmacologically relevant signal transduction molecules

21 January 2018

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

21 January 2018

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Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

21 January 2018

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Caveolin-1 tumor-promoting role in human melanoma

21 January 2018

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The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin

21 January 2018

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Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling

21 January 2018

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Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion

21 January 2018

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Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin.

21 January 2018

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Functional and quantitative proteomics using SILAC

21 January 2018

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Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification

21 January 2018

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Quantitative organelle proteomics of MCF-7 breast cancer cells reveals multiple subcellular locations for proteins in cellular functional processes

21 January 2018

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Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers.

21 January 2018

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Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma

21 January 2018

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Heterogeneous nuclear ribonucleoprotein A1 is identified as a potential biomarker for colorectal cancer based on differential proteomics technology

21 January 2018

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Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature

21 January 2018

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Exosomes: proteomic insights and diagnostic potential

21 January 2018

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Proteomic analysis of exosomes isolated from human malignant pleural effusions

21 January 2018

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Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer.

21 January 2018

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Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach

21 January 2018

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Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells

21 January 2018

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Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

21 January 2018

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Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy

21 January 2018

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

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Proteomic analysis of membrane rafts of melanoma cells identifies protein patterns characteristic of the tumor progression stage.

21 January 2018

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Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma.

21 January 2018

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Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts

21 January 2018

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Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase.

21 January 2018

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The application of mass spectrometry to membrane proteomics

21 January 2018

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Proteomic analysis of detergent-resistant membrane rafts

21 January 2018

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Proteomic analysis of plasma membrane lipid rafts of HL-60 cells

21 January 2018

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Lipid raft proteomics: analysis of in-solution digest of sodium dodecyl sulfate-solubilized lipid raft proteins by liquid chromatography-matrix-assisted laser desorption/ionization tandem mass spectrometry

21 January 2018

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Lipid raft proteome reveals ATP synthase complex in the cell surface.

21 January 2018

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Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes

21 January 2018

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Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering

21 January 2018

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Quantitative profiling of the detergent-resistant membrane proteome of iota-b toxin induced vero cells

21 January 2018

1 reference

A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells

21 January 2018

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Combined chemical and enzymatic stable isotope labeling for quantitative profiling of detergent-insoluble membrane proteins isolated using Triton X-100 and Brij-96.

21 January 2018

1 reference

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

21 January 2018

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Current two-dimensional electrophoresis technology for proteomics

21 January 2018

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Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis.

21 January 2018

1 reference

Mass spectrometric analysis of the glycosphingolipid-enriched microdomains of rat natural killer cells.

21 January 2018

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Detergent-free caveolae proteome suggests an interaction with ER and mitochondria

21 January 2018

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Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

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Monocyte lipid rafts contain proteins implicated in vesicular trafficking and phagosome formation.

21 January 2018

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Subcellular proteomics of cell differentiation: Quantitative analysis of the plasma membrane proteome of Caco-2 cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EPR.11.2

1 reference

24 August 2017

1 reference

PubMed ID

21501018