(Q37877829)

24 August 2017

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title

Topoisomerases, new targets in cancer chemotherapy (English)

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24 August 2017

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Zijlstra JG

1

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24 August 2017

de Jong S

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2

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24 August 2017

de Vries EG

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3

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24 August 2017

Mulder NH

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4

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24 August 2017

1 January 1990

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Medical oncology and tumor pharmacotherapy

24 August 2017

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24 August 2017

7

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24 August 2017

1

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24 August 2017

11-18

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Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

24 August 2017

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12 December 2020

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro

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12 December 2020

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

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12 December 2020

Recent studies of DNA topoisomerases

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12 December 2020

Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage

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12 December 2020

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells

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12 December 2020

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction

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12 December 2020

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

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12 December 2020

Mechanism of inhibition of mammalian DNA topoisomerase I by heparin

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12 December 2020

Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization

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12 December 2020

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins.

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12 December 2020

An Improved Method to Detect Small Amounts of Radiation Damage in DNA of Eukaryotic Cells

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

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12 December 2020

Expression of the Drosophila type II topoisomerase is developmentally regulated

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12 December 2020

Mitoxantrone affects topoisomerase activities in human breast cancer cells

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12 December 2020

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

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12 December 2020

Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target

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12 December 2020

Characterization of a camptothecin-resistant human DNA topoisomerase I

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12 December 2020

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage

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12 December 2020

Rapid detection and isolation of covalent DNA/protein complexes: application to topoisomerase I and II.

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12 December 2020

Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs

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12 December 2020

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

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12 December 2020

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment

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12 December 2020

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function

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12 December 2020

Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.

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12 December 2020

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene

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12 December 2020

Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases α and β

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12 December 2020

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12 December 2020

BD-40, an ellipticine-related DNA intercalative agent induces DNA-protein bridges in vivo

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12 December 2020

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

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12 December 2020

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

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12 December 2020

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells

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12 December 2020

Topoisomerase-specific drug sensitivity in relation to cell cycle progression

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12 December 2020

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

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12 December 2020

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

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12 December 2020

Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells

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12 December 2020

DNA topoisomerases: from a laboratory curiosity to a subject in cancer chemotherapy

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12 December 2020

Purification and characterization of Plasmodium berghei DNA topoisomerases I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage.

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12 December 2020

Topoisomerases in human disease

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12 December 2020

Metaphase chromosome structure. Involvement of topoisomerase II

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12 December 2020

Reduced formation of protein-associated DNA strand breaks in Chinese hamster cells resistant to topoisomerase II inhibitors

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12 December 2020

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II

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12 December 2020

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

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12 December 2020

DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide

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12 December 2020

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity

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12 December 2020

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme

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12 December 2020

Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D

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12 December 2020

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

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12 December 2020

Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells

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12 December 2020

Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA

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12 December 2020

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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12 December 2020

Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines

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12 December 2020

The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases

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12 December 2020

Combined modalities of resistance in etoposide-resistant human KB cell lines.

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12 December 2020

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

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12 December 2020

Inhibitors of DNA topoisomerases

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12 December 2020

Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro

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12 December 2020

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

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12 December 2020

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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12 December 2020

Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase.

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12 December 2020

In vitro transcription of eukaryotic genes is affected differently by the degree of DNA supercoiling

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12 December 2020

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

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12 December 2020

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

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12 December 2020

Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells

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12 December 2020

Supercoiling of the DNA template during transcription

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12 December 2020

DNA topoisomerase II cleaves at specific sites in the 5' flanking region of c-fos proto-oncogenes in vitro

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12 December 2020

Altered function of DNA topoisomerases as a basis for antineoplastic drug action

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12 December 2020

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

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12 December 2020

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12 December 2020

Effect of cell proliferation and chromatin conformation on intercalator-induced, protein-associated DNA cleavage in human brain tumor cells and human fibroblasts.

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12 December 2020

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

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12 December 2020

Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation)

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12 December 2020

DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators

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12 December 2020

A fluorescence enhancement assay for cellular DNA damage

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12 December 2020

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

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12 December 2020

Cross-sensitivity to topoisomerase II inhibitors in cytotoxic drug-hypersensitive Chinese hamster ovary cell lines.

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12 December 2020

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

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12 December 2020

Cell cycle dependence of sister chromatid exchange induction by DNA topoisomerase II inhibitors in Chinese hamster V79 cells

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12 December 2020

Mechanism of resistance of noncycling mammalian cells to 4'-(9-acridinylamino)methanesulfon-m-anisidide: comparison of uptake, metabolism, and DNA breakage in log- and plateau-phase Chinese hamster fibroblast cell cultures.

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12 December 2020

Topoisomerase II: A specific marker for cell proliferation

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12 December 2020

Topoisomerase II cleavage in chromatin

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12 December 2020

DNA topoisomerases as targets for cancer therapy

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12 December 2020

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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12 December 2020

Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis.

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12 December 2020

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells

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12 December 2020

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

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12 December 2020

Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide in L1210 murine leukemia cells

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12 December 2020

Cooperative sequestration of m-AMSA in L1210 cells

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12 December 2020

A homogeneous type II DNA topoisomerase from HeLa cell nuclei

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12 December 2020

DNA topoisomerase II is required at the time of mitosis in yeast

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12 December 2020

DNA topoisomerases and DNA repair

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12 December 2020

The interaction between nuclear topoisomerase II activity from human leukemia cells, exogenous DNA, and 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) or 4-(4,6-O-ethylidene-beta-D-glucopyranoside) (VP-16) indicates the sensitivity of the c

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12 December 2020

Levels of topoisomerase II and DNA polymerase alpha are regulated independently in developing neuronal nuclei.

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12 December 2020

Cell cycle stage dependent variations in drug-induced topoisomerase II mediated DNA cleavage and cytotoxicity

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12 December 2020

Epidermal growth factor-induced topoisomerase(s). Intracellular translocation and relation to DNA synthesis

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12 December 2020

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors

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12 December 2020

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

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12 December 2020

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line

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12 December 2020

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12 December 2020

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells

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12 December 2020

Decatenation of kinetoplast DNA by topoisomerases

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12 December 2020

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

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12 December 2020

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

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12 December 2020

Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.

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12 December 2020

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

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12 December 2020

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle

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12 December 2020

Identifiers

DOI

10.1007/BF03000485

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24 August 2017

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