(Q37879596)

24 August 2017

1 reference

title

Cellular effects of progranulin in health and disease (English)

1 reference

24 August 2017

Louis De Muynck

1

1 reference

PubMed ID

21611805

24 August 2017

Philip Van Damme

series ordinal

2

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24 August 2017

25 May 2011

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Journal of Molecular Neuroscience

24 August 2017

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24 August 2017

45

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24 August 2017

3

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24 August 2017

549-560

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https://scigraph.springernature.com/pub.10.1007/s12031-011-9553-z

24 August 2017

0 references

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Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis

21 January 2018

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Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

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ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor

21 January 2018

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21 January 2018

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

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The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system

21 January 2018

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The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection

21 January 2018

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Structure and chromosomal location of the human granulin gene

21 January 2018

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Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

21 January 2018

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Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

21 January 2018

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GEP, a local growth factor, is critical for odontogenesis and amelogenesis.

21 January 2018

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Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

21 January 2018

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TAR DNA-binding protein 43 in neurodegenerative disease

21 January 2018

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Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Gene expression study on peripheral blood identifies progranulin mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Cortical atrophy and language network reorganization associated with a novel progranulin mutation.

21 January 2018

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

21 January 2018

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Cellular localization of gene expression for progranulin

21 January 2018

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Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor).

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

21 January 2018

1 reference

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Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

21 January 2018

1 reference

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Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.

21 January 2018

1 reference

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Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration.

21 January 2018

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A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin is a mediator of the wound response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Identification of genes involved in the host response to neurovirulent alphavirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin expression in advanced human atherosclerotic plaque

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

High-density microarray analysis of hippocampal gene expression following experimental brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin expression is upregulated after spinal contusion in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

21 January 2018

Frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin expression in the developing and adult murine brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Microglial upregulation of progranulin as a marker of motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin is a chemoattractant for microglia and stimulates their endocytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The prevalence of frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin is expressed within motor neurons and promotes neuronal cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The activation of Akt/PKB signaling pathway and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Pathogenic cysteine mutations affect progranulin function and production of mature granulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9553-Z

Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance

21 January 2018

1 reference

12 December 2020

Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival.

1 reference

12 December 2020

Somatostatin-, vasoactive intestinal peptide-, and granulin-like peptides isolated from intestinal extracts of goldfish, Carassius auratus

1 reference

12 December 2020

Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo

1 reference

12 December 2020

Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein

1 reference

12 December 2020

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

1 reference

12 December 2020

Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters

1 reference

12 December 2020

PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma

1 reference

12 December 2020

GEP associates with wild-type p53 in hepatocellular carcinoma.

1 reference

12 December 2020

Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption

1 reference

12 December 2020

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury

1 reference

12 December 2020

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

1 reference

12 December 2020

Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression

1 reference

12 December 2020

Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis

1 reference

12 December 2020

Biological activities and signaling pathways of the granulin/epithelin precursor

1 reference

12 December 2020

Expression pattern of progranulin in the human placenta and its effect on cell proliferation in the choriocarcinoma cell line BeWo

1 reference

12 December 2020

Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

1 reference

12 December 2020

Biochemical analysis of the epithelin receptor

1 reference

12 December 2020

Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex

1 reference

12 December 2020

The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.

1 reference

12 December 2020

10.1007/S12031-011-9553-Z

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21611805