(Q37880547)

24 August 2017

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title

Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections (English)

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24 August 2017

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Faulds D

1

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24 August 2017

Heel RC

series ordinal

2

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24 August 2017

publication date

1 April 1990

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24 August 2017

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24 August 2017

volume

39

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24 August 2017

issue

4

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24 August 2017

page(s)

597-638

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Retinal toxicity of ganciclovir in vitrectomy infusion solution

24 August 2017

cites work

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12 December 2020

Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U)

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12 December 2020

Treatment of cytomegalovirus pneumonia

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12 December 2020

Cytomegalovirus infection in the acquired immune deficiency syndrome

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12 December 2020

Treatment of cytomegalovirus infections in renal transplant recipients with 9-(1,3-dihydroxy-2-propoxymethyl) guanine

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12 December 2020

Treatment of cytomegalovirus pneumonitis after bone marrow transplantation with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine

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12 December 2020

Breakthrough of cytomegalovirus infection despite 9-(1,3-dihydroxy-2-propoxymethyl)guanine therapy

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12 December 2020

Experimental ocular herpetic infections in rabbits. Treatment with 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine

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12 December 2020

Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy

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12 December 2020

Human pharmacokinetics of the antiviral drug DHPG.

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12 December 2020

Pathologic features of cytomegalovirus retinopathy after treatment with the antiviral agent ganciclovir

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12 December 2020

Successful treatment of severe cytomegalovirus infections with ganciclovir and CMV hyperimmune globulin in liver transplant recipients

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12 December 2020

Regression of cauda equina syndrome in AIDS patient being treated with ganciclovir

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12 December 2020

Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus

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12 December 2020

Cytomegalovirus infection, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, and Crohn's disease

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12 December 2020

Development of cytomegalovirus (CMV) retinitis in a patient with AIDS during ganciclovir therapy for CMV colitis

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12 December 2020

Effects of the nucleoside analog 2'-nor-2'-deoxyguanosine on human cytomegalovirus replication

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12 December 2020

Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men

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12 December 2020

Human pharmacokinetics and tolerance of oral ganciclovir

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12 December 2020

Comparison of the in vitro and in vivo antiherpes virus activities of the acyclic nucleosides, acyclovir (Zovirax) and 9-[(2-hydroxy-1-hydroxymethylethoxy)methyl]guanine (BWB759U).

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12 December 2020

Treatment of cytomegalovirus retinitis in a patient with AIDS with 9-(1,3-dihydroxy-2-propoxymethyl)guanine.

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12 December 2020

Ganciclovir pharmacokinetics during renal impairment

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12 December 2020

Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells

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12 December 2020

Ganciclovir treatment of cytomegalovirus infections in iatrogenically immunocompromised patients

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12 December 2020

Combined antibody and ganciclovir treatment of murine cytomegalovirus-infected normal and immunosuppressed BALB/c mice

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12 December 2020

Ganciclovir treatment of life- or sight-threatening cytomegalovirus infection: experience in 314 immunocompromised patients

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12 December 2020

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

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12 December 2020

A competitive enzyme-linked immunosorbent assay to quantitate acyclovir and BW B759U in human plasma and urine

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12 December 2020

Inhibitory effects of selected antiviral compounds on newly isolated clinical varicella-zoster virus strains

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12 December 2020

Treatment of cytomegalovirus pneumonia in heart transplant recipients with 9(1,3-dihydroxy-2-proproxymethyl)-guanine (DHPG)

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12 December 2020

Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration

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12 December 2020

Intestinal infections in patients with the acquired immunodeficiency syndrome (AIDS). Etiology and response to therapy

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12 December 2020

CMV retinitis treated with ganciclovir [9(1,3-dihydroxy-2-propoxymethyl) guanine] in patients with AIDS

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12 December 2020

9-(1-3-Dihydroxy-2-propoxymethyl)guanine prevents death but not immunity in murine cytomegalovirus-infected normal and immunosuppressed BALB/c mice

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12 December 2020

Acyclovir A Review of its Pharmacodynamic Properties and Therapeutic Efficacy

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12 December 2020

Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs

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12 December 2020

Successful treatment with ganciclovir of disseminated cytomegalovirus infection after liver transplantation

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12 December 2020

Interaction of 9-(1,3-dihydroxy-2-propoxymethyl)guanine with cytosol and mitochondrial deoxyguanosine kinases: possible role in anti-cytomegalovirus activity

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12 December 2020

Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment

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12 December 2020

Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

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12 December 2020

Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro

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12 December 2020

Synthesis of cytomegalovirus DNA is an antiviral target late in virus growth

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12 December 2020

Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine

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12 December 2020

Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells

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12 December 2020

Successful treatment of murine cytomegalovirus disease does not prevent latent virus infection

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12 December 2020

Treatment of cytomegalovirus retinitis with ganciclovir

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12 December 2020

Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells

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12 December 2020

In vitro susceptibility of cytomegalovirus isolates from immunocompromised patients to acyclovir and ganciclovir.

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12 December 2020

[Studies on the cytotoxicity of a new anti-herpetic agent, 9-(1,3-dihydroxy-2-propoxymethyl) guanine, on the rabbit cornea]

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12 December 2020

Effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on viral DNA and protein synthesis in cells infected with herpes simplex virus

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12 December 2020

Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir

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12 December 2020

Life-threatening cytomegalovirus infection treated with dihydropropoxymethylguanine

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12 December 2020

Ganciclovir in the treatment of cytomegalovirus pneumonitis in bone marrow transplant recipients

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12 December 2020

Effect of antiviral agents on replication of herpes simplex virus type 1 in brain cultures

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12 December 2020

Anti-herpes simplex virus (HSV) effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea

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12 December 2020

Effect of combinations of difluoromethylornithine (DFMO) and 9[(1,3-dihydroxy-2-propoxy) methyl]guanine (DHPG) on human cytomegalovirus

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12 December 2020

9-(1,3-Dihydroxy-2-propoxymethyl)guanine for cytomegalovirus infections in patients with the acquired immunodeficiency syndrome

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12 December 2020

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with gamma interferon against herpes simplex virus type 2 in mice

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12 December 2020

Synergism between recombinant human interferon and nucleoside antiviral agents against herpes simplex virus: examination with an automated microtiter plate assay

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12 December 2020

Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds

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12 December 2020

Clinical pharmacokinetics of ganciclovir in patients with normal and impaired renal function

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12 December 2020

Treatment of cytomegalovirus pneumonitis with ganciclovir in renal transplantation

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12 December 2020

Progress in the treatment of cytomegalovirus pneumonia

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12 December 2020

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

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12 December 2020

In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses

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12 December 2020

Failure of adjunctive cytomegalovirus intravenous immune globulin to improve efficacy of ganciclovir in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: a phase 1 study

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12 December 2020

Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons

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12 December 2020

Ganciclovir treatment of serious cytomegalovirus infection in heart and heart-lung transplant recipients.

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12 December 2020

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication

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12 December 2020

Ganciclovir/immunoglobulin combination therapy for the treatment of human cytomegalovirus-associated interstitial pneumonia in bone marrow allograft recipients

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12 December 2020

Intravitreal ganciclovir in the treatment of AIDS-associated cytomegalovirus retinitis

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12 December 2020

Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U

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12 December 2020

2'-Nor-cGMP: a seco-cyclic nucleotide with powerful anti-DNA-viral activity

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12 December 2020

2'-Nor-2'-deoxyguanosine is an effective therapeutic agent for treatment of experimental herpes keratitis

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12 December 2020

High-dose intravitreal gancyclovir for cytomegaloviral (CMV) retinitis.

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12 December 2020

Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients

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12 December 2020

[A 9-week-old infant with congenital cytomegalic inclusion disease and therapy with ganciclovir]

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12 December 2020

Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy

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12 December 2020

Intravenous and intraocular ganciclovir for CMV retinitis in patients with AIDS or chemotherapeutic immunosuppression

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12 December 2020

Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine

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12 December 2020

BW B759U for cytomegalovirus retinitis: intraocular drug penetration

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12 December 2020

Efficacy of BW759 (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) against herpes simplex virus type 1 keratitis in rabbits

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12 December 2020

Nucleic acid hybridization for measurement of effects of antiviral compounds on human cytomegalovirus DNA replication

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12 December 2020

Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine

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12 December 2020

Intravitreous ganciclovir for patients receiving zidovudine

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12 December 2020

Kaposi's sarcoma of the conjunctiva and CMV-retinitis in AIDS.

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12 December 2020

A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2

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12 December 2020

Ganciclovir treatment of cytomegalovirus disease in immunocompromised children

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12 December 2020

BWB759U, an analogue of acyclovir, inhibits human cytomegalovirus in vitro

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12 December 2020

Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the acute local phase of herpes simplex virus-induced skin infections in mice and the establishment of latency

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12 December 2020

Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir

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12 December 2020

High-performance liquid chromatographic method for the determination of 9-(1,3-dihydroxy-2-propoxymethyl)guanine in human plasma

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12 December 2020

Ganciclovir therapy of severe cytomegalovirus infections in solid-organ transplant recipients

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12 December 2020

Treatment of cytomegalovirus gastrointestinal ulceration in a heart transplant patient

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12 December 2020

Efficacy of ganciclovir in liver and kidney transplant recipients with severe cytomegalovirus infection.

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12 December 2020

A comparison of the antiviral agents 2′-nor-2′-deoxyguanosine and acyclovir: Uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates

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12 December 2020

Antiviral activity and mechanism of action of ganciclovir

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12 December 2020

Stimulation of Cellular Thymidine Kinases by Human Cytomegalovirus

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12 December 2020

Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus

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12 December 2020

Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine

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12 December 2020

Ganciclovir treatment of cytomegalovirus infection of the gastrointestinal tract after marrow transplantation

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12 December 2020

Ganciclovir for severe cytomegalovirus infection in transplant recipients

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12 December 2020

Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

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12 December 2020

Treatment of disseminated cytomegalovirus infection with 9-(1,3 dihydroxy-2-propoxymethyl)guanine: evidence of prolonged survival in patients with the acquired immunodeficiency syndrome

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12 December 2020

Activity of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia

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12 December 2020

Use of ganciclovir to treat serious cytomegalovirus infections in patients with AIDS

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12 December 2020

Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1

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12 December 2020

Treatment of cytomegalovirus retinitis with intravitreal ganciclovir. Long-term results

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12 December 2020

Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts

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12 December 2020

Antiviral effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against cytomegalovirus infection in a guinea pig model

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12 December 2020

Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function

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12 December 2020

Antiviral therapy with ganciclovir for cytomegalovirus retinitis and bilateral exudative retinal detachments in an immunocompromised child

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12 December 2020

Retinal and gastrointestinal disease due to cytomegalovirus in patients with the acquired immune deficiency syndrome: prevalence, natural history, and response to ganciclovir therapy

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12 December 2020

Intravitreal toxicity of hydroxyacyclovir (BW-B759U), a new antiviral agent

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12 December 2020

Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir

1 reference

12 December 2020

GM-CSF with ganciclovir for the treatment of CMV retinitis in AIDS

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12 December 2020

Interactions of cytomegalovirus with the human immune system

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12 December 2020

Ganciclovir therapy for cytomegalovirus infections in recipients of bone marrow transplants and other immunosuppressed patients

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12 December 2020

Thrombocytopenia and vitreous hemorrhage complicating ganciclovir treatment

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12 December 2020

Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin

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12 December 2020

Ganciclovir for the treatment and suppression of serious infections caused by cytomegalovirus

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12 December 2020

Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl)guanine in patients with AIDS and other immunodeficiencies

1 reference

12 December 2020

Efficacy of 2'-nor-2'-deoxyguanosine treatment for orofacial herpes simplex virus type 1 skin infections in mice

1 reference

12 December 2020

Phosphorylation of the antiviral precursor 9-(1,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes

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12 December 2020

Treatment of cytomegalovirus retinopathy with ganciclovir

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12 December 2020

Ganciclovir for severe cytomegalovirus infection in transplant recipients

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12 December 2020

Ganciclovir therapy in iatrogenically immunosuppressed patients with cytomegalovirus disease

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12 December 2020

Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus

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12 December 2020

Tolerance and efficacy of ganciclovir in the treatment of cytomegalovirus infections in immunosuppressed patients

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12 December 2020

Failure of antiviral therapy for acquired immunodeficiency syndrome-related cytomegalovirus myelitis

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12 December 2020

Use of ganciclovir in the treatment of cytomegalovirus infections

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12 December 2020

Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants

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12 December 2020

Ganciclovir therapy for cytomegalovirus disease associated with renal transplants

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12 December 2020

A Quantitative Study of the Effects of Several Nucleoside Analogues on Established Herpes Encephalitis in Mice

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12 December 2020

Randomized prospective trial of ganciclovir maintenance therapy for cytomegalovirus retinitis

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12 December 2020

Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses

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12 December 2020

Sensitivity of clinical isolates of human cytomegalovirus to 9-(1,3-dihydroxy-2-propoxymethyl)guanine

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12 December 2020

GM-CSF and ganciclovir for cytomegalovirus infection after autologous bone-marrow transplantation

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12 December 2020

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

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12 December 2020

Toxicity trial of prophylactic 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine (ganciclovir) after marrow transplantation in dogs

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12 December 2020

Cytomegalovirus infection and renal transplantation

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12 December 2020

Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase

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12 December 2020

Long-term intravitreal ganciclovir for cytomegalovirus retinitis in a patient with AIDS. Case report

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12 December 2020

Ganciclovir treatment of gastrointestinal infections caused by cytomegalovirus in patients with AIDS

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12 December 2020

Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir

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12 December 2020

Identification of an Epstein-Barr virus-coded thymidine kinase

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12 December 2020

Successful treatment of cytomegalovirus disease with 9-(1,3-dihydroxy-2-propoxymethyl guanine).

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12 December 2020

Intraocular penetration of new antiviral agent, hydroxyacyclovir (BW-B759U)

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12 December 2020

Potent synergistic inhibition of herpes simplex virus-2 by 9-[(1, 3-dihydroxy-2-propoxy) methyl]guanine in combination with recombinant interferons

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12 December 2020

Ganciclovir for treatment of renal transplant-associated primary cytomegalovirus pneumonia

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12 December 2020

Cytomegalovirus retinitis and response to therapy with ganciclovir

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12 December 2020

Intravitreal ganciclovir in CMV retinitis: case report

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12 December 2020

Multifocal cytomegalovirus encephalitis in AIDS.

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12 December 2020

Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine

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12 December 2020

Is cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological condition?

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12 December 2020

Treatment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine

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12 December 2020

Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

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12 December 2020

Acyclovir and Epstein--Barr virus infection

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12 December 2020

Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information

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12 December 2020

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice

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12 December 2020

Cytomegalovirus infections in heart and heart-lung transplant recipients

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12 December 2020

Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir)

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12 December 2020

Ganciclovir--a review of pharmacology, therapeutic efficacy and potential use for treatment of congenital cytomegalovirus infections

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12 December 2020

Interstitial pneumonitis during murine cytomegalovirus infection and graft-versus-host reaction: effect of ganciclovir therapy

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12 December 2020

Efficacy of ganciclovir against cytomegalovirus nephropathy after kidney transplantation

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12 December 2020

Ganciclovir prophylaxis for cochlear pathophysiology during experimental guinea pig cytomegalovirus labyrinthitis

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12 December 2020

A Radioimmunoassay Procedure for the Determination of the Antiviral Nucleoside DHPG (9-[(l,3-Dihydroxy-2-propoxy)-methyl]guanine) in Plasma or Serum

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12 December 2020

Differential effects of acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on herpes simplex virus and Epstein-Barr virus in a dually infected human lymphoblastoid cell line

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12 December 2020

Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides

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12 December 2020

Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir

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12 December 2020

Staphylococcus epidermidis endophthalmitis complicating intravitreal antiviral therapy of cytomegalovirus retinitis. Case report

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12 December 2020

Use of intravitreal ganciclovir (dihydroxy propoxymethyl guanine) for cytomegalovirus retinitis in a patient with AIDS.

1 reference

12 December 2020

Comparative efficacy and selectivity of some nucleoside analogs against Epstein-Barr virus

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12 December 2020

10.2165/00003495-199039040-00008

Identifiers

DOI

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Dimensions Publication ID

24 August 2017

1024316518

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