(Q37909427)

25 August 2017

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title

Insect cell technology is a versatile and robust vaccine manufacturing platform (English)

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25 August 2017

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Jimmy A Mena

1

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25 August 2017

Amine A Kamen

series ordinal

2

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25 August 2017

publication date

1 July 2011

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Expert Review of Vaccines

25 August 2017

published in

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25 August 2017

volume

10

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25 August 2017

issue

7

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25 August 2017

page(s)

1063-1081

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Baculovirus-insect cell expression systems.

25 August 2017

cites work

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Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge

21 January 2018

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Efficient gene transfer into human hepatocytes by baculovirus vectors

21 January 2018

1 reference

Influenza virus-like particle vaccines

21 January 2018

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Vaccines for viral and parasitic diseases produced with baculovirus vectors

21 January 2018

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Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic

21 January 2018

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Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system

21 January 2018

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Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system.

21 January 2018

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Improving adeno-associated vector yield in high density insect cell cultures

21 January 2018

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Population kinetics during simultaneous infection of insect cells with two different recombinant baculoviruses for the production of rotavirus-like particles

21 January 2018

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Large scale production and downstream processing of a recombinant porcine parvovirus vaccine

21 January 2018

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Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cells expressing recombinant proteins

21 January 2018

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Modeling the population dynamics of baculovirus-infected insect cells: Optimizing infection strategies for enhanced recombinant protein yields

21 January 2018

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Avian influenza virus hemagglutinin display on baculovirus envelope: cytoplasmic domain affects virus properties and vaccine potential

21 January 2018

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Development of a simple and high-yielding fed-batch process for the production of influenza vaccines

21 January 2018

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A phase I evaluation of the safety and immunogenicity of vaccination with recombinant gp160 in patients with early human immunodeficiency virus infection. Military Medical Consortium for Applied Retroviral Research

21 January 2018

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GAD treatment and insulin secretion in recent-onset type 1 diabetes

21 January 2018

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Evaluation of the safety, reactogenicity and immunogenicity of FluBlok trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy children aged 6-59 months

21 January 2018

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FluBlok, a next generation influenza vaccine manufactured in insect cells

21 January 2018

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GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes

21 January 2018

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Immunotherapy (APC8015, Provenge) targeting prostatic acid phosphatase can induce durable remission of metastatic androgen-independent prostate cancer: a Phase 2 trial

21 January 2018

1 reference

Sipuleucel-T immunotherapy for castration-resistant prostate cancer

21 January 2018

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Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer

21 January 2018

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Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells

21 January 2018

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Safety and efficacy of a recombinant hepatitis E vaccine

21 January 2018

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Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans.

21 January 2018

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Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus

21 January 2018

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Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein

21 January 2018

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Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design

21 January 2018

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A recombinant baculovirus-expressed S glycoprotein vaccine elicits high titers of SARS-associated coronavirus (SARS-CoV) neutralizing antibodies in mice

21 January 2018

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Recombinant influenza B virus HA and NA antigens administered in equivalent amounts are immunogenically equivalent and induce equivalent homotypic and broader heterovariant protection in mice than conventional and live influenza vaccines

21 January 2018

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A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells

21 January 2018

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Enhancement of protective humoral immune responses against Herpes simplex virus-2 in DNA-immunized guinea-pigs using protein boosting

21 January 2018

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Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I.

21 January 2018

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Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum

21 January 2018

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Protection induced by Plasmodium falciparum MSP1(42) is strain-specific, antigen and adjuvant dependent, and correlates with antibody responses

21 January 2018

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Efficacy of the classical swine fever (CSF) marker vaccine Porcilis Pesti in pregnant sows

21 January 2018

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Classical swine fever (CSF) marker vaccine. Trial II. Challenge study in pregnant sows.

21 January 2018

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Marker vaccine strategies and candidate CSFV marker vaccines

21 January 2018

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Safety and efficacy of a classical swine fever subunit vaccine in pregnant sows and their offspring

21 January 2018

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Expression and immunological studies of classical swine fever virus glycoprotein E2 in the bi-cistronic baculovirus/larvae expression system

21 January 2018

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The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex

21 January 2018

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Evaluation of a bovine rotavirus VP6 vaccine efficacy in the calf model of infection and disease

21 January 2018

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Evaluation of efficacy of mammalian and baculovirus expressed E2 subunit vaccine candidates to bovine viral diarrhoea virus

21 January 2018

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Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins

21 January 2018

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Baculovirus-derived hemagglutinin vaccine protects chickens from lethal homologous virus H5N1 challenge

21 January 2018

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Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle

21 January 2018

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Vaccination of dogs with six different candidate leishmaniasis vaccines composed of a chimerical recombinant protein containing ribosomal and histone protein epitopes in combination with different adjuvants

21 January 2018

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Bioprocessing of baculovirus vectors: a review

21 January 2018

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Trichoplusia ni cells (High Five) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vaccines

21 January 2018

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Swine-origin pandemic H1N1 influenza virus-like particles produced in insect cells induce hemagglutination inhibiting antibodies in BALB/c mice.

21 January 2018

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Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

21 January 2018

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Engineering of baculovirus vectors for the manufacture of virion-free biopharmaceuticals.

21 January 2018

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Downstream processing of triple layered rotavirus like particles

21 January 2018

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Rotavirus-like particles primary recovery from insect cells in aqueous two-phase systems

21 January 2018

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Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Indian women

21 January 2018

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Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial

21 January 2018

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Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years

21 January 2018

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Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types.

21 January 2018

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Type-specific and cross-reactive antibodies induced by human papillomavirus 31 L1/L2 virus-like particles

21 January 2018

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Production and purification of human papillomavirus type 33 L1 virus-like particles from Spodoptera frugiperda 9 cells using two-step column chromatography

21 January 2018

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Production of parvovirus B19 vaccine in insect cells co-infected with double baculoviruses

21 January 2018

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Enhanced kinetic extraction of parvovirus B19 structural proteins.

21 January 2018

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Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1.

21 January 2018

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Conformational stability and disassembly of Norwalk virus-like particles. Effect of pH and temperature

21 January 2018

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Recombinant virus-like particles of a norovirus (genogroup II strain) administered intranasally and orally with mucosal adjuvants LT and LT(R192G) in BALB/c mice induce specific humoral and cellular Th1/Th2-like immune responses

21 January 2018

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Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers

21 January 2018

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Virus-like particles as a vaccine delivery system: myths and facts.

21 January 2018

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Intrarectal immunization with rotavirus 2/6 virus-like particles induces an antirotavirus immune response localized in the intestinal mucosa and protects against rotavirus infection in mice

21 January 2018

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Intussusception among infants given an oral rotavirus vaccine

21 January 2018

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Intracellular distribution of rotavirus structural proteins and virus-like particles expressed in the insect cell-baculovirus system

21 January 2018

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Biochemical and immunologic comparison of virus-like particles for a rotavirus subunit vaccine.

21 January 2018

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Production of hybrid double- or triple-layered virus-like particles of group A and C rotaviruses using a baculovirus expression system

21 January 2018

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Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice

21 January 2018

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Oral and intraperitoneal immunization with rotavirus 2/6 virus-like particles stimulates a systemic and mucosal immune response in mice

21 January 2018

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Distribution and phenotype of murine rotavirus-specific B cells induced by intranasal immunization with 2/6 virus-like particles

21 January 2018

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Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection

21 January 2018

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Strategies for manipulating the relative concentration of recombinant rotavirus structural proteins during simultaneous production by insect cells

21 January 2018

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Triple layered rotavirus VLP production: kinetics of vector replication, mRNA stability and recombinant protein production.

21 January 2018

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Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant hepatitis E virus-like particles

21 January 2018

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Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield

21 January 2018

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Expression, purification and characterization of enterovirus-71 virus-like particles

21 January 2018

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Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice.

21 January 2018

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A novel intranasal virus-like particle (VLP) vaccine designed to protect against the pandemic 1918 influenza A virus (H1N1).

21 January 2018

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Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin

21 January 2018

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Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle

21 January 2018

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H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses.

21 January 2018

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Induction of long-term protective immune responses by influenza H5N1 virus-like particles.

21 January 2018

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Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus

21 January 2018

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Virus-like particle vaccine conferred complete protection against a lethal influenza virus challenge

21 January 2018

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Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis

21 January 2018

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Immune responses against severe acute respiratory syndrome coronavirus induced by virus-like particles in mice

21 January 2018

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Assembly of human severe acute respiratory syndrome coronavirus-like particles

21 January 2018

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Virus-like particles of SARS-like coronavirus formed by membrane proteins from different origins demonstrate stimulating activity in human dendritic cells

21 January 2018

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Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice

21 January 2018

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Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies

21 January 2018

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Protection against lethal challenge by Ebola virus-like particles produced in insect cells

21 January 2018

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Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents

21 January 2018

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Protection against filovirus infection: virus-like particle vaccines

21 January 2018

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One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

21 January 2018

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Immunogenicity of empty capsids of porcine circovius type 2 produced in insect cells

21 January 2018

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Efficient production of type 2 porcine circovirus-like particles by a recombinant baculovirus

21 January 2018

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Immunity conferred by an experimental vaccine based on the recombinant PCV2 Cap protein expressed in Trichoplusia ni-larvae.

21 January 2018

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A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure.

21 January 2018

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Validation of a novel approach for the rapid production of immunogenic virus-like particles for bluetongue virus.

21 January 2018

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Assessment of the protection afforded by triple baculovirus recombinant coexpressing H5, N3, M1 proteins against a homologous H5N3 low-pathogenicity avian influenza virus challenge in Muscovy ducks

21 January 2018

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Achievement of avian influenza virus-like particles that could be used as a subunit vaccine against low-pathogenic avian influenza strains in ducks

21 January 2018

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Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs

21 January 2018

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Production of porcine parvovirus empty capsids with high immunogenic activity

21 January 2018

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Baculovirus as vaccine vectors

21 January 2018

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Baculovirus as an expression and/or delivery vehicle for vaccine antigens

21 January 2018

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Baculovirus vector as a delivery vehicle for influenza vaccines

21 January 2018

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Efficient transduction of mammalian cells by a recombinant baculovirus having the vesicular stomatitis virus G glycoprotein

21 January 2018

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Construction and immunogenicity of pseudotype baculovirus expressing GP5 and M protein of porcine reproductive and respiratory syndrome virus

21 January 2018

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Purification of recombinant baculoviruses for gene therapy using membrane processes.

21 January 2018

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High yield purification of functional baculovirus vectors by size exclusion chromatography

21 January 2018

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Ion-exchange membrane chromatography method for rapid and efficient purification of recombinant baculovirus and baculovirus gp64 protein

21 January 2018

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Baculovirus as an avian influenza vaccine vector: differential immune responses elicited by different vector forms

21 January 2018

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A baculovirus dual expression system-based malaria vaccine induces strong protection against Plasmodium berghei sporozoite challenge in mice

21 January 2018

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Baculovirus-based vaccination vectors allow for efficient induction of immune responses against plasmodium falciparum circumsporozoite protein

21 January 2018

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Safety and immunogenicity of H5N1 influenza vaccine based on baculovirus surface display system of Bombyx mori

21 January 2018

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Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop fo

21 January 2018

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SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitro

21 January 2018

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Current Status of Veterinary Vaccines

21 January 2018

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Efficacy and stability of a subunit vaccine based on glycoprotein E2 of classical swine fever virus

21 January 2018

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Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2.

21 January 2018

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Enhanced papillomavirus-like particle production in insect cells

21 January 2018

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T-helper cell-mediated interferon-gamma, interleukin-10 and proliferation responses to a candidate recombinant vaccine for human parvovirus B19.

21 January 2018

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Physical stabilization of Norwalk virus-like particles

21 January 2018

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Comparison of the efficacy of rotavirus VLP vaccines to a live homologous rotavirus vaccine in a pig model of rotavirus disease

21 January 2018

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An oral versus intranasal prime/boost regimen using attenuated human rotavirus or VP2 and VP6 virus-like particles with immunostimulating complexes influences protection and antibody-secreting cell responses to rotavirus in a neonatal gnotobiotic pi

21 January 2018

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Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

21 January 2018

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Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge

21 January 2018

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Baculovirus-derived human immunodeficiency virus type 1 virus-like particles activate dendritic cells and induce ex vivo T-cell responses.

21 January 2018

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Induction of systemic and mucosal cross-clade neutralizing antibodies in BALB/c mice immunized with human immunodeficiency virus type 1 clade A virus-like particles administered by different routes of inoculation

21 January 2018

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HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine

21 January 2018

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Human immunodeficiency virus type-1 (HIV-1) Pr55gag virus-like particles are potent activators of human monocytes

21 January 2018

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Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses

21 January 2018

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Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells

21 January 2018

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Expression of foot-and-mouth disease virus capsid proteins in silkworm-baculovirus expression system and its utilization as a subunit vaccine

21 January 2018

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Neutralizing epitopes of influenza virus hemagglutinin: target for the development of a universal vaccine against H5N1 lineages

21 January 2018

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Gastrointestinal delivery of baculovirus displaying influenza virus hemagglutinin protects mice against heterologous H5N1 infection.

21 January 2018

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Hemagglutinin displayed baculovirus protects against highly pathogenic influenza

21 January 2018

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Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmission-blocking vaccine candidate antigen

21 January 2018

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Baculovirus-based nasal drop vaccine confers complete protection against malaria by natural boosting of vaccine-induced antibodies in mice

21 January 2018

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Baculovirus surface display of SARS coronavirus (SARS-CoV) spike protein and immunogenicity of the displayed protein in mice models

21 January 2018

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A chimeric baculovirus displaying bovine herpesvirus-1 (BHV-1) glycoprotein D on its surface and their immunological properties.

21 January 2018

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Construction and immunogenicity of pseudotype baculovirus expressing Toxoplasma gondii SAG1 protein in BALB/c mice model

21 January 2018

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Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice

21 January 2018

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Immune responses induced by a BacMam virus expressing the E2 protein of classical swine fever virus in mice

21 January 2018

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Baculovirus surface display of E(rns) envelope glycoprotein of classical swine fever virus

21 January 2018

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Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus

21 January 2018

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A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens.

21 January 2018

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New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection.

21 January 2018

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Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins

21 January 2018

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Intracellular dynamics in rotavirus-like particles production: Evaluation of multigene and monocistronic infection strategies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERV.11.24

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25 August 2017

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