(Q37928570)

25 August 2017

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title

The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer (English)

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25 August 2017

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Taj D King

1

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25 August 2017

Mark J Suto

series ordinal

2

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25 August 2017

Yonghe Li

series ordinal

3

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25 August 2017

publication date

1 January 2012

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Journal of Cellular Biochemistry

25 August 2017

published in

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25 August 2017

volume

113

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25 August 2017

issue

1

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25 August 2017

page(s)

13-18

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Prospective identification of tumorigenic breast cancer cells

25 August 2017

cites work

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The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage

21 January 2018

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The internally truncated LRP5 receptor presents a therapeutic target in breast cancer

21 January 2018

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Triple-negative breast cancer: disease entity or title of convenience?

21 January 2018

1 reference

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

1 reference

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

21 January 2018

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Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines

21 January 2018

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β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

21 January 2018

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Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

21 January 2018

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

21 January 2018

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The CD44+/CD24- phenotype is enriched in basal-like breast tumors

21 January 2018

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Wnt signaling and breast cancer

21 January 2018

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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

21 January 2018

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Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome.

21 January 2018

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Multiplicity of the interactions of Wnt proteins and their receptors

21 January 2018

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

21 January 2018

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R-Spondin proteins: a novel link to beta-catenin activation

21 January 2018

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Epigenetic gene silencing in the Wnt pathway in breast cancer

21 January 2018

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Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.

21 January 2018

1 reference

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

21 January 2018

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Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation

21 January 2018

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Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

21 January 2018

1 reference

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

21 January 2018

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The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

21 January 2018

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LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

21 January 2018

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A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences

21 January 2018

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Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

21 January 2018

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Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells

21 January 2018

1 reference

Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth

21 January 2018

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Dynamic expression of R-spondin family genes in mouse development.

21 January 2018

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Wnt signaling and stem cell control

21 January 2018

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The many ways of Wnt in cancer

21 January 2018

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

21 January 2018

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A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer

21 January 2018

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Wnt signalling in stem cells and cancer

21 January 2018

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Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

21 January 2018

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Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

21 January 2018

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MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors

21 January 2018

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MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

21 January 2018

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

21 January 2018

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R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

21 January 2018

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WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells

21 January 2018

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FZD7 has a critical role in cell proliferation in triple negative breast cancer

21 January 2018

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Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23350

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25 August 2017

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