(Q37930959)

25 August 2017

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title

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility (English)

1 reference

25 August 2017

Victor M Navarro

1

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25 August 2017

Manuel Tena-Sempere

series ordinal

2

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25 August 2017

publication date

13 September 2011

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Nature Reviews Endocrinology

25 August 2017

published in

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25 August 2017

volume

8

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25 August 2017

issue

1

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25 August 2017

page(s)

40-53

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Novel signals for the integration of energy balance and reproduction

25 August 2017

cites work

1 reference

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Hypothalamic pathways linking energy balance and reproduction

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From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

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AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1

21 January 2018

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The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54

21 January 2018

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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

21 January 2018

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The GPR54 gene as a regulator of puberty

21 January 2018

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Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol

21 January 2018

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Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition

21 January 2018

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Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

21 January 2018

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Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

GPR54 and kisspeptin in reproduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse

21 January 2018

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Regulation of Kiss1 gene expression in the brain of the female mouse.

21 January 2018

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Sexual differentiation of Kiss1 gene expression in the brain of the rat.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

21 January 2018

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Characterization of Kiss1 neurons using transgenic mouse models

21 January 2018

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Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The neuroanatomy of the kisspeptin system in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Distribution of kisspeptin neurones in the adult female mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neurokinin B and the hypothalamic regulation of reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Sexual differentiation of the vertebrate nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Roles of kisspeptins in the control of hypothalamic-gonadotropic function: focus on sexual differentiation and puberty onset.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptins: bridging energy homeostasis and reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Ghrelin as a pleotrophic modulator of gonadal function and reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin indirectly regulates gonadotropin-releasing hormone neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Effect of diabetes mellitus upon male reproductive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Neuroendocrinology of nutritional infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

KiSS-1 neurones are direct targets for leptin in the ob/ob mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin is an effective treatment for hypothalamic amenorrhea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin in male reproduction: the testis paradigm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Identification of targets of leptin action in rat hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Energetic cell sensors: a key to metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Hypothalamic mTOR signaling regulates food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Regulation of food intake through hypothalamic signaling networks involving mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

The Creb1 coactivator Crtc1 is required for energy balance and fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Mouse fertility is not dependent on the CREB coactivator Crtc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing hormone neurons by NMDA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in an estradiol-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Gonadotropin-releasing hormone neuron requirements for puberty, ovulation, and fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Transgenic mouse models to study Gpr54/kisspeptin physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.147

31 March 2020

Identifiers

DOI

10.1038/NRENDO.2011.147

1 reference

25 August 2017

1 reference