(Q37942500)

25 August 2017

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title

The gene or not the gene--that is the question: understanding the genetically engineered mouse phenotype (English)

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25 August 2017

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R S Sellers

1

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25 August 2017

publication date

4 October 2011

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25 August 2017

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25 August 2017

volume

49

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25 August 2017

issue

1

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25 August 2017

page(s)

5-15

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Contemporary approaches for modifying the mouse genome

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A behavioral and neuroanatomical assessment of an inbred substrain of 129 mice with behavioral comparisons to C57BL/6J mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F0300985811421324

Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Identification of mutations in the COL4A5 collagen gene in Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

The liberation of embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Talking about a Revolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Evaluating mutant mice: anatomic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

The Role of the Floor Plate in Axon Guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Behavioral differences among 129 substrains: implications for knockout and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Introduction of a rabbit beta-globin gene into the mouse germ line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

The lac operator-repressor system is functional in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Flanking gene and genetic background problems in genetically manipulated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Influence of genetic background on genetically engineered mouse phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Bacterial probiotic modulation of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Nuclear factor I X deficiency causes brain malformation and severe skeletal defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Cautionary insights on knockout mouse studies: the gene or not the gene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Establishment in culture of pluripotential cells from mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

PhiC31 integrase and liver-specific regulatory elements confer high-level, long-term expression of firefly luciferase in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Site-specific integration of transgene targeting an endogenous lox-like site in early mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

X-linked Alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Lung disease in mice with cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Mutations in the type IV collagen alpha 3 (COL4A3) gene in autosomal recessive Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Zinc finger nuclease technology heralds a new era in mammalian transgenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Increased axon number in the anterior commissure of mice lacking a corpus callosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Tests of genetic allelism between four inbred mouse strains with absent corpus callosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Complementation of null CF mice with a human CFTR YAC transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Genetically manipulated mice: a powerful tool with unsuspected caveats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Behavioural performance in three substrains of mouse strain 129.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Generation of germline-competent induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Reprogramming of human somatic cells to pluripotency with defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Disrupted in schizophrenia 1: building brains and memories

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Mutation of the Emx-1 homeobox gene disrupts the corpus callosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A role for cingulate pioneering axons in the development of the corpus callosum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Experimental inflammatory bowel disease: insights into the host-microbiota dialog

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Interpretation of knockout experiments: the congenic footprint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Derivation of pluripotent stem cells from cultured human primordial germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A conditional knockout resource for the genome-wide study of mouse gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

The transcription factor gene Nfib is essential for both lung maturation and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Induction of pluripotent stem cells from fibroblast cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Bi-allelic gene targeting in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Embryonic stem cell lines derived from human blastocysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Isolation of a primate embryonic stem cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Mammalian genomes contain active recombinase recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

A direct measurement of the radiation sensitivity of normal mouse bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Deficient corpus callosum in hybrids between ddN and three other abnormal mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specific Trp53 platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Speed congenics: applications for transgenic and knock-out mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

Strain-dependent epithelial defects in mice lacking the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0300985811421324

21 January 2018

Identifiers

DOI

10.1177/0300985811421324

1 reference

25 August 2017

1 reference