(Q37944471)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21989576%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Cell-cell connectivity: desmosomes and disease (English)

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14 February 2020

1

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14 February 2020

David P. Kelsell

series ordinal

3

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14 February 2020

author name string

Daniela Nitoiu

series ordinal

2

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14 February 2020

publication date

14 November 2011

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14 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21989576%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

226

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14 February 2020

issue

2

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14 February 2020

page(s)

158-171

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Intercellular junction assembly, dynamics, and homeostasis

14 February 2020

cites work

1 reference

Adherens junction: molecular architecture and regulation

21 January 2018

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Molecular components of the adherens junction.

21 January 2018

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Deconstructing the cadherin-catenin-actin complex

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Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin

21 January 2018

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Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)

21 January 2018

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P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle

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The promise and perils of Wnt signaling through beta-catenin.

21 January 2018

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Role of Wnt canonical pathway in hematological malignancies

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Key functions for gap junctions in skin and hearing

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Connexins and cell signaling in development and disease

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Connexin mutations in skin disease and hearing loss

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Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

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Connexin-26 mutations in sporadic and inherited sensorineural deafness

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Epithelial barriers in homeostasis and disease

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Structure and function of claudins.

21 January 2018

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Physiology and function of the tight junction

21 January 2018

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The tight junction: a multifunctional complex

21 January 2018

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Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption

21 January 2018

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Paracellin-1 and the modulation of ion selectivity of tight junctions

21 January 2018

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Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement

21 January 2018

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Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.

21 January 2018

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Tricellulin is a tight-junction protein necessary for hearing

21 January 2018

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Junctional complexes in various epithelia

21 January 2018

1 reference

Fine structure of desmosomes. , hemidesmosomes, and an adepidermal globular layer in developing newt epidermis

21 January 2018

1 reference

Structure and function of desmosomes

21 January 2018

1 reference

Are desmosomes more than tethers for intermediate filaments?

21 January 2018

1 reference

Desmosomes: adhesive strength and signalling in health and disease.

21 January 2018

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21 January 2018

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Desmosomal adhesion inhibits invasive behavior

21 January 2018

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Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

21 January 2018

1 reference

Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains

21 January 2018

1 reference

Isoform-Specific Differences in the Size of Desmosomal Cadherin/Catenin Complexes

21 January 2018

1 reference

The desmosome: cell science lessons from human diseases

21 January 2018

1 reference

The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms

21 January 2018

1 reference

Pemphigus vulgaris and pemphigus foliaceus sera show an inversely graded binding pattern to extracellular regions of desmosomes in different layers of human epidermis

21 January 2018

1 reference

Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis

21 January 2018

1 reference

The bovine desmocollin family: a new gene and expression patterns reflecting epithelial cell proliferation and differentiation.

21 January 2018

1 reference

Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues

21 January 2018

1 reference

21 January 2018

1 reference

Order and disorder in corneocyte adhesion

21 January 2018

1 reference

Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease

21 January 2018

1 reference

Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin

21 January 2018

1 reference

Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.

21 January 2018

1 reference

Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis

21 January 2018

1 reference

Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion.

21 January 2018

1 reference

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes

21 January 2018

1 reference

Intermediate filaments and the initiation of desmosome assembly

21 January 2018

1 reference

Structure and mechanism of cadherins and catenins in cell-cell contacts

21 January 2018

1 reference

Induction of hyper-adhesion attenuates autoimmune-induced keratinocyte cell-cell detachment and processing of adhesion molecules via mechanisms that involve PKC.

21 January 2018

1 reference

The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells

21 January 2018

1 reference

Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure

21 January 2018

1 reference

Calcium-independent desmosomes of keratinocytes are hyper-adhesive.

21 January 2018

1 reference

Stabilization of plakoglobin and enhanced keratinocyte cell-cell adhesion by intracellular O-glycosylation

21 January 2018

1 reference

P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3.

21 January 2018

1 reference

The p120 family of cell adhesion molecules

21 January 2018

1 reference

Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?

21 January 2018

1 reference

Interactions of Plakoglobin and -Catenin with Desmosomal Cadherins: BASIS OF SELECTIVE EXCLUSION OF - AND -CATENIN FROM DESMOSOMES

21 January 2018

1 reference

Structure of the armadillo repeat domain of plakophilin 1

21 January 2018

1 reference

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

21 January 2018

1 reference

Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components

21 January 2018

1 reference

Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)

21 January 2018

1 reference

Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues

21 January 2018

1 reference

The area composita of adhering junctions connecting heart muscle cells of vertebrates - III: assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture.

21 January 2018

1 reference

The function of plakophilin 1 in desmosome assembly and actin filament organization

21 January 2018

1 reference

A role for plakophilin-1 in the initiation of desmosome assembly

21 January 2018

1 reference

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling

21 January 2018

1 reference

Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin

21 January 2018

1 reference

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

21 January 2018

1 reference

Structure and function of desmosomal transmembrane core and plaque molecules

21 January 2018

1 reference

Regulation of desmosome assembly and adhesion

21 January 2018

1 reference

Identification and characterization of DSPIa, a novel isoform of human desmoplakin

21 January 2018

1 reference

The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins

21 January 2018

1 reference

Desmoplakin is essential in epidermal sheet formation

21 January 2018

1 reference

Desmosomes and disease: pemphigus and bullous impetigo

21 January 2018

1 reference

Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

21 January 2018

1 reference

Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1

21 January 2018

1 reference

Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. A mechanism for the loss of epidermal cohesion and blister formation

21 January 2018

1 reference

Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies

21 January 2018

1 reference

Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells

21 January 2018

1 reference

Assembly pathway of desmoglein 3 to desmosomes and its perturbation by pemphigus vulgaris-IgG in cultured keratinocytes, as revealed by time-lapsed labeling immunoelectron microscopy

21 January 2018

1 reference

Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies

21 January 2018

1 reference

Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity

21 January 2018

1 reference

Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3

21 January 2018

1 reference

Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism

21 January 2018

1 reference

Staphylococcal exfoliative toxins: "molecular scissors" of bacteria that attack the cutaneous defense barrier in mammals.

21 January 2018

1 reference

Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.

21 January 2018

1 reference

Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.

21 January 2018

1 reference

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome

21 January 2018

1 reference

Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin

21 January 2018

1 reference

Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation.

21 January 2018

1 reference

Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering

21 January 2018

1 reference

Skin and heart: une liaison dangereuse

21 January 2018

1 reference

A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy

21 January 2018

1 reference

Homozygous mutation of desmocollin-2 in arrhythmogenic right ventricular cardiomyopathy with mild palmoplantar keratoderma and woolly hair.

21 January 2018

1 reference

Compound heterozygosity for new splice site mutations in the plakophilin 1 gene (PKP1) in a Chinese case of ectodermal dysplasia-skin fragility syndrome

21 January 2018

1 reference

Ectodermal dysplasia-skin fragility syndrome resulting from a new homozygous mutation, 888delC, in the desmosomal protein plakophilin 1.

21 January 2018

1 reference

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation

21 January 2018

1 reference

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation

21 January 2018

1 reference

Molecular abnormalities of the desmosomal protein desmoplakin in human disease.

21 January 2018

1 reference

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma

21 January 2018

1 reference

Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome

21 January 2018

1 reference

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma

21 January 2018

1 reference

Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa

21 January 2018

1 reference

Embryonic heart and skin defects in mice lacking plakoglobin

21 January 2018

1 reference

Plakoglobin is required for effective intermediate filament anchorage to desmosomes

21 January 2018

1 reference

Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling

21 January 2018

1 reference

Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).

21 January 2018

1 reference

Naxos disease and Carvajal syndrome: cardiocutaneous disorders that highlight the pathogenesis and broaden the spectrum of arrhythmogenic right ventricular cardiomyopathy

21 January 2018

1 reference

The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease.

21 January 2018

1 reference

Cardiomyopathy with alopecia and palmoplantar keratoderma (CAPK) is caused by a JUP mutation

21 January 2018

1 reference

Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity

21 January 2018

1 reference

Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children

21 January 2018

1 reference

A nonsense mutation in the desmoglein 1 gene underlies striate keratoderma

21 January 2018

1 reference

N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma

21 January 2018

1 reference

DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy

21 January 2018

1 reference

Darier disease : a disease model of impaired calcium homeostasis in the skin

21 January 2018

1 reference

Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease

21 January 2018

1 reference

21 January 2018

ER stress and diseases.

1 reference

Dependence of epithelial intercellular junction biogenesis on thapsigargin-sensitive intracellular calcium stores

21 January 2018

1 reference

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

21 January 2018

1 reference

ADAMs: modulators of cell–cell and cell–matrix interactions

21 January 2018

1 reference

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

21 January 2018

1 reference

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis

21 January 2018

1 reference

Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells

21 January 2018

1 reference

EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.

21 January 2018

1 reference

Inflammatory skin and bowel disease linked to ADAM17 deletion

21 January 2018

1 reference

Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases

21 January 2018

1 reference

Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer

21 January 2018

1 reference

Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion

21 January 2018

1 reference

Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study

21 January 2018

1 reference

DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis

21 January 2018

1 reference

Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer

21 January 2018

1 reference

Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression

21 January 2018

1 reference

Desmosomes: new perpetrators in tumour suppression

21 January 2018

1 reference

Perp is a p63-regulated gene essential for epithelial integrity.

21 January 2018

1 reference

Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis

21 January 2018

1 reference

Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

21 January 2018

1 reference

Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation

21 January 2018

1 reference

Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation

21 January 2018

1 reference

Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes

21 January 2018

1 reference

Desmoglein isoform distribution affects stratum corneum structure and function

21 January 2018

1 reference

Loss of desmocollin 3 in mice leads to epidermal blistering

21 January 2018

1 reference

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

21 January 2018

1 reference

Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2

21 January 2018

1 reference

Plakophilin 1 stimulates translation by promoting eIF4A1 activity

21 January 2018

1 reference

The Wnt signalling pathway

21 January 2018

1 reference

A Wnt survival guide: from flies to human disease.

21 January 2018

1 reference

Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis

21 January 2018

1 reference

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

21 January 2018

1 reference

A non-sense mutation in the corneodesmosin gene in a Mexican family with hypotrichosis simplex of the scalp

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.3027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21989576%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference