(Q37946333)

25 August 2017

Mechanotransduction of shear in the endothelium: basic studies and clinical implications (English)

1 reference

25 August 2017

0 references

1 reference

Blair D Johnson

1

1 reference

PubMed ID

22003002

25 August 2017

Kieren J Mather

series ordinal

2

1 reference

PubMed ID

22003002

25 August 2017

Janet P Wallace

series ordinal

3

1 reference

25 August 2017

1 October 2011

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25 August 2017

1 reference

25 August 2017

16

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25 August 2017

5

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25 August 2017

365-377

1 reference

Vascular mechanobiology: endothelial cell responses to fluid shear stress

25 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Secrets of the code: do vascular endothelial cells use ion channels to decipher complex flow signals?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

The mechanosensitive nature of TRPV channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Endogenously released ATP mediates shear stress-induced Ca2+influx into pulmonary artery endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Endothelial Ca2+ waves preferentially originate at specific loci in caveolin-rich cell edges

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Haemodynamic shear stress activates a K+ current in vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

A model for shear stress-induced deformation of a flow sensor on the surface of vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

G protein-coupled receptors sense fluid shear stress in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Mechanotransduction across the cell surface and through the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

The endothelial glycocalyx: a mechano-sensor and -transducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Blood-flow sensing by anionic biopolymers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Endothelial mechanotransduction, nitric oxide and vascular inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Primary cilia of human endothelial cells disassemble under laminar shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Molecular basis of the effects of shear stress on vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Stimulation of transcription factors NF kappa B and AP1 in endothelial cells subjected to shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: role of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

The Ras-JNK pathway is involved in shear-induced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Role of Ca2+ and protein kinase C in shear stress-induced actin depolymerization and endothelin 1 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

The transcription factor NF-kappa B and the regulation of vascular cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Frequency-dependent response of the vascular endothelium to pulsatile shear stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress-induced release of nitric oxide from endothelial cells grown on beads

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear str

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Physiologic stress-mediated signaling in the endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Differential membrane potential and ion current responses to different types of shear stress in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Assessment of brachial artery blood flow across the cardiac cycle: retrograde flows during cycle ergometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Molecular mechanism of endothelial growth arrest by laminar shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Induction of human inhibitor of apoptosis protein-2 by shear stress in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Effects of disturbed flow on endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Large variations in absolute wall shear stress levels within one species and between species

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Shear stress mediates endothelial adaptations to exercise training in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Brachial artery blood flow responses to different modalities of lower limb exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Increases in blood flow and shear stress to nonworking limbs during incremental exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Impact of shear rate modulation on vascular function in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Point: exercise training does induce vascular adaptations beyond the active muscle beds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Moderate exercise is an antioxidant: upregulation of antioxidant genes by training.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Exercise, oxidative stress and hormesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Exercise and hormesis: activation of cellular antioxidant signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Retrograde flow and shear rate acutely impair endothelial function in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Sympathetic vasomotor control does not explain the change in femoral artery shear rate pattern during arm-crank exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Primary cilia sensitize endothelial cells for fluid shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

Contribution of endogenous generation of endothelin-1 to basal vascular tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1358863X11422109

21 January 2018

Identifiers

DOI

10.1177/1358863X11422109

1 reference

25 August 2017

1 reference

PubMed ID

22003002