(Q37977276)

26 August 2017

title

α-Secretase-derived cleavage of cellular prion yields biologically active catabolites with distinct functions (English)

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26 August 2017

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M-V Guillot-Sestier

1

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26 August 2017

F Checler

series ordinal

2

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26 August 2017

language of work or name

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17 January 2012

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Neurodegenerative Diseases

26 August 2017

published in

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26 August 2017

volume

10

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26 August 2017

issue

1-4

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26 August 2017

page(s)

294-297

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26 August 2017

cites work

Prion Protein Biology

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Prions: health scare and biological challenge.

21 January 2018

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Birth of a prion: spontaneous generation revisited

21 January 2018

1 reference

21 January 2018

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Physiology of the prion protein

21 January 2018

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Truncated forms of the human prion protein in normal brain and in prion diseases.

21 January 2018

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Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation

21 January 2018

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The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

21 January 2018

1 reference

Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons

21 January 2018

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M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity.

21 January 2018

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Isoform-specific contribution of protein kinase C to prion processing.

21 January 2018

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The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.

21 January 2018

1 reference

Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators.

21 January 2018

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ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε.

21 January 2018

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Neurotoxicity of a prion protein fragment.

21 January 2018

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Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

21 January 2018

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Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

21 January 2018

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Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis.

21 January 2018

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Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: a proteomic study.

21 January 2018

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Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

21 January 2018

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The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.

21 January 2018

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APP carboxyl-terminal fragment without or with abeta domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000333804

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26 August 2017

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