(Q37980245)

26 August 2017

title

From global phosphoproteomics to individual proteins: the case of translation elongation factor eEF1A. (English)

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26 August 2017

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26 August 2017

3

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26 August 2017

Dmytro Vlasenko

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26 August 2017

publication date

1 January 2012

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Expert Review of Proteomics

26 August 2017

published in

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26 August 2017

volume

9

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26 August 2017

issue

1

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26 August 2017

page(s)

71-83

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Decoding signalling networks by mass spectrometry-based proteomics

26 August 2017

cites work

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Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations

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The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

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Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

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An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3

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Regulation of the unfolded protein response by eif2Bdelta isoforms.

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TGFβ enforces activation of eukaryotic elongation factor‐2 (eEF2) via inactivation of eEF2 kinase by p90 ribosomal S6 kinase (p90Rsk) to induce mesangial cell hypertrophy

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Channeling of aminoacyl-tRNA for protein synthesis in vivo

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eEF1A: thinking outside the ribosome

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Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha

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Microtubule severing by elongation factor 1 alpha

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Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A.

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Chaperone-like activity of mammalian elongation factor eEF1A: renaturation of aminoacyl-tRNA synthetases

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eEF1A is a novel component of the mammalian nuclear protein export machinery

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Unbalanced expression of the translation complex eEF1 subunits in human cardioesophageal carcinoma

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eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI.

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Interaction between the Cellular Protein eEF1A and the 3'-Terminal Stem-Loop of West Nile Virus Genomic RNA Facilitates Viral Minus-Strand RNA Synthesis

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Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor.

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Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA

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Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

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The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex

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Cloning and expression of a novel human antibody-antigen pair associated with Felty's syndrome.

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Comparative proteome analysis using amine-reactive isobaric tagging reagents coupled with 2D LC/MS/MS in 3T3-L1 adipocytes following hypoxia or normoxia

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A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death

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Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

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Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach

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Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility.

21 January 2018

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Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus.

21 January 2018

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The prognostic significance of elongation factor eEF1A2 in ovarian cancer

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The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

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High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines.

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Etiology-dependent molecular mechanisms in human hepatocarcinogenesis

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Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray

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Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis

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Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress

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Heat shock protein 27 delays Ca2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells

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Elongation factor-1 alpha is a selective regulator of growth factor withdrawal and ER stress-induced apoptosis

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Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol

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Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.

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Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

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Novel flavonoids with antiproliferative activities against breast cancer cells

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Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells

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Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells

21 January 2018

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Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase

21 January 2018

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Determination of site-specificity of S-glutathionylated cellular proteins

21 January 2018

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Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal

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Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA1: focus on vimentin

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A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules

21 January 2018

1 reference

Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation

21 January 2018

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Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity

21 January 2018

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Protein kinase KIS localizes to RNA granules and enhances local translation

21 January 2018

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Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

21 January 2018

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Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma

21 January 2018

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Phosphorylation of eEF1A1 at Ser300 by TβR-I Results in Inhibition of mRNA Translation

21 January 2018

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A quantitative atlas of mitotic phosphorylation

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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

21 January 2018

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A common phosphotyrosine signature for the Bcr-Abl kinase

21 January 2018

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

21 January 2018

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eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration

21 January 2018

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Signaling networks assembled by oncogenic EGFR and c-Met

21 January 2018

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A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation

21 January 2018

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An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells

21 January 2018

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Large-scale phosphorylation analysis of mouse liver

21 January 2018

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A tissue-specific atlas of mouse protein phosphorylation and expression

21 January 2018

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Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.

21 January 2018

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

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Extended conformation of mammalian translation elongation factor 1A in solution.

21 January 2018

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Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha

21 January 2018

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Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin

21 January 2018

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A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database

21 January 2018

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WHAT IF: a molecular modeling and drug design program

21 January 2018

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The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with GDP reveals novel features in nucleotide binding and exchange

21 January 2018

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Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation

21 January 2018

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When proteomics meets structural biology

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Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain

21 January 2018

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Roles of three domains of Tetrahymena eEF1A in bundling F-actin

21 January 2018

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Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics

21 January 2018

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Comprehensive identification of phosphorylation sites in postsynaptic density preparations

21 January 2018

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Phosphoproteomic analysis of the developing mouse brain

21 January 2018

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Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry

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Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence Disorder

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Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain

21 January 2018

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Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain

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GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection.

21 January 2018

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Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas

21 January 2018

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Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae

21 January 2018

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Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry

21 January 2018

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Phosphoproteome analysis of Drosophila melanogaster embryos

21 January 2018

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Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos

21 January 2018

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21 January 2018

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PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites

21 January 2018

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A curated compendium of phosphorylation motifs

21 January 2018

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

21 January 2018

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Phosphoproteome Analysis of Fission Yeast

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/EPR.11.71

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26 August 2017

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