(Q37982662)

26 August 2017

5 references

20 June 2019

22 June 2019

19 November 2019

8 September 2020

3 October 2022

Role of basic science in the development of new medicines: examples from the eicosanoid field (English)

1 reference

26 August 2017

1 reference

19 November 2019

1 reference

8 September 2020

Bengt Samuelsson

1

1 reference

PMCID

3323017

26 August 2017

language of work or name

English

0 references

publication date

8 February 2012

1 reference

PMCID

3323017

26 August 2017

23 March 2012

5 references

20 June 2019

22 June 2019

19 November 2019

8 September 2020

3 October 2022

11

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

6 references

26 August 2017

20 June 2019

22 June 2019

19 November 2019

8 September 2020

3 October 2022

287

1 reference

26 August 2017

13

1 reference

26 August 2017

10070-10080

1 reference

Creative Commons Attribution-NonCommercial

26 August 2017

5 references

20 June 2019

22 June 2019

19 November 2019

8 September 2020

3 October 2022

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Membrane prostaglandin E synthase-1: a novel therapeutic target

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Structure and catalytic mechanisms of leukotriene A4 hydrolase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Liberation of histamine and formation of lysocithin-like substances by cobra venom

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

THE ENZYMATIC FORMATION OF PROSTAGLANDIN E2 FROM ARACHIDONIC ACID PROSTAGLANDINS AND RELATED FACTORS 32.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

THE BIOSYNTHESIS OF PROSTAGLANDINS.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Platelet-active drugs : the relationships among dose, effectiveness, and side effects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Molecular cloning and amino acid sequence of leukotriene A4 hydrolase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Introduction of a nomenclature: Leukotrienes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Leukotriene C: a slow-reacting substance from murine mastocytoma cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

The chemical structure of prostaglandin X (prostacyclin)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

The physicochemical characteristics and purification of slow-reacting substance of anaphylaxis.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Slow-reacting substance of anaphylaxis Purification and characterisation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323017

Leukotriene A4 hydrolase: an epoxide hydrolase with peptidase activity

1 September 2018

1 reference

12 December 2020

Oxygenation of Unsaturated Fatty Acids by the Vesicular Gland of Sheep

1 reference

12 December 2020

ON THE INCORPORATION OF OXYGEN IN THE CONVERSION OF 8, 11, 14-EICOSATRIENOIC ACID TO PROSTAGLANDIN E1

1 reference

12 December 2020

Leukotriene A. Isolation from human polymorphonuclear leukocytes

1 reference

12 December 2020

Stereochemistry of leukotriene C-1

1 reference

12 December 2020

1 reference

12 December 2020

Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.X112.351437

1 reference

26 August 2017

1 reference

26 August 2017

1 reference

PMCID

3323017