(Q37992101)

26 August 2017

title

Protein kinase C βII in diabetic complications: survey of structural, biological and computational studies (English)

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26 August 2017

main subject

computational biology

1 reference

M Elizabeth Sobhia

1

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26 August 2017

Baljinder K Grewal

2

1 reference

26 August 2017

Jyotsna Bhat

3

1 reference

26 August 2017

Shishir Rohit

4

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26 August 2017

Vijay Punia

5

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26 August 2017

language of work or name

English

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publication date

1 March 2012

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Expert Opinion on Therapeutic Targets

26 August 2017

published in

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26 August 2017

volume

16

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26 August 2017

issue

3

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26 August 2017

page(s)

325-344

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Protein kinase C: structure, function, and regulation

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

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21 January 2018

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Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

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Studies and perspectives of protein kinase C.

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PKC-B inhibition: a new therapeutic approach for diabetic complications?

21 January 2018

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Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The role of protein kinase C activation and the vascular complications of diabetes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The potential role of PKC beta in diabetic retinopathy and macular edema

21 January 2018

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Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.

21 January 2018

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Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

21 January 2018

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Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells

21 January 2018

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Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

21 January 2018

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Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes

21 January 2018

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Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy

21 January 2018

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

21 January 2018

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The molecular mechanism linking muscle fat accumulation to insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Identification of a functional protein kinase Cbeta promoter polymorphism in humans related to insulin resistance

21 January 2018

1 reference

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Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

21 January 2018

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Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes

21 January 2018

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Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance

21 January 2018

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The life and death of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Structural basis of protein kinase C isoform function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The extended protein kinase C superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Crystal Structure and Allosteric Activation of Protein Kinase C βII

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Molecular dynamics characterization of the C2 domain of protein kinase Cbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus

21 January 2018

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Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The potential of protein kinase C as a target for anticancer treatment

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

21 January 2018

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Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Computational methods for biomolecular docking.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Predicting molecular interactions in silico: I. A guide to pharmacophore identification and its applications to drug design

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Protein kinase C isozymes and their selectivity towards ruboxistaurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Insights into the structural requirements of PKCβII inhibitors based on HQSAR and CoMSIA analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Targeting PKC-β II by Peptides and Peptidomimetics Derived from RACK 1: An In Silico Approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Targeting PKC-β II and PKB Connection: Design of Dual Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Selectivity and therapeutic inhibition of kinases: to be or not to be?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.667804

10.1517/14728222.2012.667804

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference