(Q37993678)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

0 references

0 references

juvenile rheumatoid arthritis

1 reference

1 reference

1 reference

macrophage activation syndrome

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Randy Quentin Cron

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

A A Grom

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

E M Behrens

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

publication date

15 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

289-298

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/gene.2012.3

25 January 2020

exact match

0 references

cites work

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Macrophage activation syndrome in the acute phase of Kawasaki disease

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Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis

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Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

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The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis.

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An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis.

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21 January 2018

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21 January 2018

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Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH.

21 January 2018

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Defective natural killer cell function in patients with hemophagocytic lymphohistiocytosis and in first degree relatives

21 January 2018

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

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Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

21 January 2018

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Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

21 January 2018

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Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

21 January 2018

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

21 January 2018

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Identification of the homologous beige and Chediak-Higashi syndrome genes

21 January 2018

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Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

21 January 2018

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XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

21 January 2018

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

21 January 2018

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Perforin is a critical physiologic regulator of T-cell activation

21 January 2018

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Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis

21 January 2018

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Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell?

21 January 2018

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Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.

21 January 2018

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Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

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Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms

21 January 2018

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Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis

21 January 2018

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Munc13-4 regulates granule secretion in human neutrophils

21 January 2018

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Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

21 January 2018

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Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis.

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

1 reference

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Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

21 January 2018

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Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice

21 January 2018

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A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).

21 January 2018

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Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

21 January 2018

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Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome.

21 January 2018

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Nucleic acid sensing Toll-like receptors in autoimmunity

21 January 2018

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Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis

21 January 2018

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Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis

21 January 2018

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Novel IL10 gene family associations with systemic juvenile idiopathic arthritis

21 January 2018

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Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice

21 January 2018

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Rabbit model for human EBV-associated hemophagocytic syndrome (HPS): sequential autopsy analysis and characterization of IL-2-dependent cell lines established from herpesvirus papio-induced fatal rabbit lymphoproliferative diseases with HPS.

21 January 2018

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G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage

21 January 2018

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Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

21 January 2018

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Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia

21 January 2018

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21 January 2018

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Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis

21 January 2018

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The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals

21 January 2018

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Hemophagocytosis causes a consumptive anemia of inflammation

21 January 2018

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Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

21 January 2018

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Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis

21 January 2018

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Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis: report of five cases

21 January 2018

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Reactive haemophagocytic syndrome in children with inflammatory disorders. A retrospective study of 24 patients

21 January 2018

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Transcription factors of the NFAT family: regulation and function

21 January 2018

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Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation

21 January 2018

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Autologous hematopoietic stem cell transplantation for 3 patients with severe juvenile rheumatoid arthritis

21 January 2018

1 reference

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Hyperferritinemia as indicator for intravenous immunoglobulin treatment in reactive macrophage activation syndromes

21 January 2018

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Immunomodulation treatment for childhood virus-associated haemophagocytic lymphohistiocytosis

21 January 2018

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Macrophage activation syndrome in a patient with systemic onset rheumatoid arthritis: rescue with intravenous immunoglobulin therapy.

21 January 2018

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Immunotherapy of Familial Hemophagocytic Lymphohistiocytosis With Antithymocyte Globulins: A Single-Center Retrospective Report of 38 Patients

21 January 2018

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Macrophage activation syndrome: serological markers and treatment with anti-thymocyte globulin

21 January 2018

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A review of the current use of rituximab in autoimmune diseases

21 January 2018

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Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis

21 January 2018

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Success with infliximab in treating refractory hemophagocytic lymphohistiocytosis

21 January 2018

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Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives

21 January 2018

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Exacerbation of adult-onset Still's disease, possibly related to elevation of serum tumor necrosis factor-alpha after etanercept administration

21 January 2018

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A rare trigger for macrophage activation syndrome

21 January 2018

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Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab

21 January 2018

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

21 January 2018

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Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series

21 January 2018

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A case of macrophage activation syndrome successfully treated with anakinra

21 January 2018

1 reference

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A 36-year-old woman with recurrent high-grade fevers, hypotension, and hypertriglyceridemia

21 January 2018

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Rapid responses to anakinra in patients with refractory adult-onset Still's disease

21 January 2018

1 reference

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Anakinra treatment in patients with adult-onset Still's disease is fast, effective, safe and steroid sparing: experience from an uncontrolled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

A 21-year-old man with Still's disease with fever, rash, and pancytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Blockade of interleukin 1 receptor in Still's disease affects activation of peripheral T-lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Acute hepatitis in three patients with systemic juvenile idiopathic arthritis taking interleukin-1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Anakinra for systemic juvenile arthritis: the Rocky Mountain experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

Macrophage activation syndrome in systemic juvenile rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Macrophage activation syndrome/Hemophagocytic Lymphohistiocytosis and Kawasaki disease

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Homeostatic regulation of CD8+ T cells by perforin

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

TLR9 contributes to antiviral immunity during gammaherpesvirus infection

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India.

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Macrophage activation syndrome in systemic juvenile rheumatoid arthritis successfully treated with cyclosporine

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Autologous stem cell transplantation in children with severe progressive systemic or polyarticular juvenile idiopathic arthritis: long-term follow-up of a prospective clinical trial

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juvenile idiopathic arthritis

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Adult-onset Still's disease with macrophage activation syndrome successfully treated with a combination of methotrexate and etanercept.

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Etanercept for therapy-resistant macrophage activation syndrome

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Successful use of infliximab in macrophage activation syndrome with severe CNS involvement

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

[Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease]

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Combination therapy of abatacept and anakinra in children with refractory systemic juvenile idiopathic arthritis: a retrospective case series

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Efficacy of anakinra in a case of refractory Still disease

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Macrophage activation syndrome treated with anakinra

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2012.3

7 January 2021

Identifiers

DOI

10.1038/GENE.2012.3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json

release_4mcuudftsbenbefokhaaltsb7e

25 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4mcuudftsbenbefokhaaltsb7e

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22418018%20AND%20SRC:MED&resulttype=core&format=json