(Q37997101)

26 August 2017

Targeting RhoA/ROCK pathway in pulmonary arterial hypertension (English)

1 reference

26 August 2017

arterial hypertension

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author name string

Sabina Antonela Antoniu

series ordinal

1

1 reference

PubMed ID

22449260

26 August 2017

language of work or name

English

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publication date

27 March 2012

1 reference

Expert Opinion on Therapeutic Targets

26 August 2017

1 reference

26 August 2017

16

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26 August 2017

4

1 reference

26 August 2017

355-363

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Treatment of pulmonary arterial hypertension

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Pulmonary arterial hypertension: a comparison between children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rho kinases in cardiovascular physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

The small GTPase Rho: cellular functions and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Development of Rho-kinase inhibitors for cardiovascular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Targeting the vasoprotective axis of the renin-angiotensin system: a novel strategic approach to pulmonary hypertensive therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Simvastatin as a treatment for pulmonary hypertension trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: role of nitric oxide and cyclic guanosine monophosphate signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Vardenafil modulates bladder contractility through cGMP-mediated inhibition of RhoA/Rho kinase signaling pathway in spontaneously hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.671811

10.1517/14728222.2012.671811

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22449260