(Q38005176)

26 August 2017

Targeting NKG2D in tumor surveillance (English)

1 reference

26 August 2017

Yoshihiro Hayakawa

1

1 reference

PubMed ID

22530569

26 August 2017

language of work or name

English

0 references

publication date

25 April 2012

1 reference

Expert Opinion on Therapeutic Targets

26 August 2017

1 reference

26 August 2017

16

1 reference

26 August 2017

6

1 reference

26 August 2017

587-599

1 reference

Cancer immunoediting: from immunosurveillance to tumor escape

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The three Es of cancer immunoediting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The immunobiology of cancer immunosurveillance and immunoediting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

A critical function for type I interferons in cancer immunoediting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

An activating immunoreceptor complex formed by NKG2D and DAP10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The role of the NKG2D immunoreceptor in immune cell activation and natural killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Roles of the NKG2D immunoreceptor and its ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Effect of NKG2D ligand expression on host immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The DNA damage response, immunity and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D and cytotoxic effector function in tumor immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D ligands in tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D is a costimulatory receptor for human naive CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-2-Activated CD8+CD44high Cells Express Both Adaptive and Innate Immune System Receptors and Demonstrate Specificity for Syngeneic Tumor Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Interleukin-15 activates human natural killer cells to clear the intestinal protozoan cryptosporidium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-21 induces the functional maturation of murine NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-21 enhances tumor rejection through a NKG2D-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Opposing effect of IFNgamma and IFNalpha on expression of NKG2 receptors: negative regulation of IFNgamma on NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D ligands: key targets of the immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

ULBP4 is a novel ligand for human NKG2D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Promiscuity and the single receptor: NKG2D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Functions of nonclassical MHC and non-MHC-encoded class I molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D function protects the host from tumor initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Innate immune recognition and suppression of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Histone deacetylases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gamma-induced microRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

NKG2D blockade prevents autoimmune diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Human tumor-derived exosomes down-modulate NKG2D expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Tumor-associated MICA is shed by ADAM proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Proteolytic release of soluble UL16-binding protein 2 from tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IFN-dependent down-regulation of the NKG2D ligand H60 on tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Interleukin 10 decreases MICA expression on melanoma cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-2/IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun N-terminal kinase (JNK) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

CEACAM1: contact-dependent control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Delivery of NKG2D ligand using an anti-HER2 antibody-NKG2D ligand fusion protein results in an enhanced innate and adaptive antitumor response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Soluble MICA in malignant diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Unique Functional Status of Natural Killer Cells in Metastatic Stage IV Melanoma Patients and Its Modulation by Chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.681378

10.1517/14728222.2012.681378

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22530569