(Q38011790)

27 August 2017

title

Recent development in software and automation tools for high-throughput discovery bioanalysis (English)

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27 August 2017

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Wilson Z Shou

1

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27 August 2017

Jun Zhang

series ordinal

2

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27 August 2017

publication date

1 May 2012

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27 August 2017

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27 August 2017

volume

4

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27 August 2017

issue

9

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27 August 2017

page(s)

1097-1109

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High throughput screening of library compounds against an oligonucleotide substructure of an RNA target

27 August 2017

cites work

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Mass spectrometric techniques for label-free high-throughput screening in drug discovery

21 January 2018

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Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening

21 January 2018

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Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.

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Development of a new permeability assay using low-efflux MDCKII cells.

21 January 2018

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High throughput screening of physicochemical properties and in vitro ADME profiling in drug discovery

21 January 2018

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Recent development in high-throughput bioanalytical support for in vitro ADMET profiling

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

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Snapshot PK: a rapid rodent in vivo preclinical screening approach.

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Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.

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Automatic mass spectrometry method development for drug discovery: application in metabolic stability assays.

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Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system

21 January 2018

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Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry

21 January 2018

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Perspectives on bioanalytical mass spectrometry and automation in drug discovery

21 January 2018

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A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen

21 January 2018

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Increasing high-throughput discovery bioanalysis using automated selected reaction monitoring compound optimization, ultra-high-pressure liquid chromatography, and single-step sample preparation workflows

21 January 2018

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High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation.

21 January 2018

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Automated 96-well SPE and LC-MS-MS for determination of protease inhibitors in plasma and cartilage tissues.

21 January 2018

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An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma

21 January 2018

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Fully automated 96-well liquid-liquid extraction for analysis of biological samples by liquid chromatography with tandem mass spectrometry

21 January 2018

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96-Well liquid-liquid extraction liquid chromatography-tandem mass spectrometry method for the quantitative determination of ABT-578 in human blood samples

21 January 2018

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Automatic Supported Liquid Extraction (SLE) Coupled with HILIC-MS/MS: An Application to Method Development and Validation of Erlotinib in Human Plasma

21 January 2018

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A highly automated 96-well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma

21 January 2018

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Flexible automated approach for quantitative liquid handling of complex biological samples

21 January 2018

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Automated sample preparation for regulated bioanalysis: an integrated multiple assay extraction platform using robotic liquid handling.

21 January 2018

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An automation-assisted generic approach for biological sample preparation and LC-MS/MS method validation.

21 January 2018

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Automated Tecan programming for bioanalytical sample preparation with EZTecan.

21 January 2018

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A fully automated plasma protein precipitation sample preparation method for LC-MS/MS bioanalysis

21 January 2018

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Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment

21 January 2018

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Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies

21 January 2018

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The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on-line extraction for high-throughout screening of drug candidates in biological fluids

21 January 2018

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Validation of a high-throughput absorption, distribution, metabolism, and excretion (ADME) system and results for 60 literature compounds

21 January 2018

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An integrated bioanalytical platform for supporting high‐throughput serum protein binding screening

21 January 2018

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Turbulent flow bioanalysis in drug metabolism and pharmacokinetics

21 January 2018

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Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma

21 January 2018

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A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening

21 January 2018

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High throughput screening via mass spectrometry: a case study using acetylcholinesterase

21 January 2018

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High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase

21 January 2018

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High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKB alpha.

21 January 2018

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Back to basics: label-free technologies for small molecule screening

21 January 2018

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Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry

21 January 2018

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Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications

21 January 2018

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Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay

21 January 2018

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High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system

21 January 2018

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Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening

21 January 2018

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Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry

21 January 2018

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A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry

21 January 2018

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High-throughput metabolic stability studies in drug discovery by orthogonal acceleration time-of-flight (OATOF) with analogue-to-digital signal capture (ADC).

21 January 2018

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Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

21 January 2018

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An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection

21 January 2018

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Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters

21 January 2018

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IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers

21 January 2018

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Enhanced metabolite identification with MS(E) and a semi-automated software for structural elucidation

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.12.51

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27 August 2017

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