(Q38012092)

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Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx.

scientific article published on 21 May 2012

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2 February 2020

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx (English)

1 reference

Europe PubMed Central

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2 February 2020

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2 February 2020

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Bettina Linnartz

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2 February 2020

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21 May 2012

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2 February 2020

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2 February 2020

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2 February 2020

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2 February 2020

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Europe PubMed Central

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2 February 2020

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

1 reference

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21 January 2018

The SIRP family of receptors and immune regulation

1 reference

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Alterations in the ganglioside composition of rat cortical brain slices during experimental lactic acidosis: implications of an enzymatic process independent of the oxidative stress.

1 reference

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21 January 2018

Neuronal 'On' and 'Off' signals control microglia

1 reference

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21 January 2018

ITAMs versus ITIMs: striking a balance during cell regulation

1 reference

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21 January 2018

Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.

1 reference

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21 January 2018

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

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21 January 2018

Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region.

1 reference

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21 January 2018

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans

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CNS immune privilege: hiding in plain sight

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The origin and cell lineage of microglia: new concepts

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Mutations in TREM2 lead to pure early-onset dementia without bone cysts.

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TREMs in the immune system and beyond

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Complement receptor 1 (CR1) and Alzheimer's disease

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Siglecs in innate immunity

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21 January 2018

Siglecs and their roles in the immune system

1 reference

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21 January 2018

Lectins as pattern recognition molecules: the effects of epitope density in innate immunity

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21 January 2018

Pattern recognition by TREM-2: binding of anionic ligands

1 reference

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21 January 2018

Oxidative damage due to copper ion and hydrogen peroxide induces GlcNAc-specific cleavage of an Asn-linked oligosaccharide

1 reference

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21 January 2018

The cell biology of phagocytosis

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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

1 reference

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21 January 2018

Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules

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21 January 2018

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

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21 January 2018

Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease

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21 January 2018

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

1 reference

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21 January 2018

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

1 reference

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21 January 2018

Oxidative changes and desialylation of serum proteins in hyperthyroidism

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

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21 January 2018

Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

1 reference

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21 January 2018

Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation.

1 reference

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21 January 2018

An ultrasensitive chemical method for polysialic acid analysis

1 reference

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21 January 2018

Cross-regulation of signaling by ITAM-associated receptors

1 reference

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21 January 2018

Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy

1 reference

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21 January 2018

Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis

1 reference

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21 January 2018

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

1 reference

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21 January 2018

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

1 reference

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21 January 2018

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia

1 reference

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21 January 2018

Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation

1 reference

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21 January 2018

Modeling Alzheimer's disease immune therapy mechanisms: interactions of human postmortem microglia with antibody-opsonized amyloid beta peptide.

1 reference

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21 January 2018

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

1 reference

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CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.

1 reference

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21 January 2018

Ligand, modulatory, and co-receptor functions of neural glycans

1 reference

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21 January 2018

Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes.

1 reference

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21 January 2018

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

1 reference

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21 January 2018

Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane

1 reference

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21 January 2018

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

1 reference

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21 January 2018

Loss of Siglec expression on T lymphocytes during human evolution

1 reference

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21 January 2018

Fcgamma receptors: old friends and new family members

1 reference

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21 January 2018

Fcgamma receptors as regulators of immune responses

1 reference

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21 January 2018

Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy

1 reference

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21 January 2018

Microarrays with varying carbohydrate density reveal distinct subpopulations of serum antibodies

1 reference

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21 January 2018

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

1 reference

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21 January 2018

Monoclonal antibodies identify three IgG Fc receptors in normal human central nervous system.

1 reference

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21 January 2018

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

1 reference

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21 January 2018

Glycosylation: An intrinsic sign of "danger"

1 reference

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21 January 2018

Microglial physiology: unique stimuli, specialized responses

1 reference

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21 January 2018

Histochemical detection of sialic acid residues using periodate oxidation

1 reference

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Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 Fragments for Factors B and H, complement receptors , and bovine conglutinin

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21 January 2018

Siglec receptors and hiding plaques in Alzheimer's disease

1 reference

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Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

1 reference

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21 January 2018

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

1 reference

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TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

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21 January 2018

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

1 reference

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Association of signal-regulatory proteins beta with KARAP/DAP-12

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21 January 2018

Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG.

1 reference

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Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

1 reference

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Natural ligands for CD33-related Siglecs?

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Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them

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Siglecs--the major subfamily of I-type lectins

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Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

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CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease

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Alleviation of neurotoxicity by microglial human Siglec-11.

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21 January 2018

Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.

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Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function

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Molecular mechanisms of CD200 inhibition of mast cell activation

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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

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Decrease in cell surface sialic acid in etoposide-treated Jurkat cells and the role of cell surface sialidase

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7 January 2021

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

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Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells

1 reference

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7 January 2021

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The chemical modification of glycosaminoglycan structure by oxygen-derived species in vitro

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7 January 2021

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Degradation of glycosaminoglycans by reactive oxygen species derived from stimulated polymorphonuclear leukocytes

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Plasma sialic acid as a marker of the effect of the treatment on metastatic colorectal cancer

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Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis

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