(Q38027947)

27 August 2017

title

Prion processing: a double-edged sword? (English)

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27 August 2017

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Hilary E M McMahon

1

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27 August 2017

publication date

1 August 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

4

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27 August 2017

page(s)

735-738

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No propagation of prions in mice devoid of PrP.

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Mice devoid of PrP are resistant to scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Purification and structural studies of a major scrapie prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

NMR structure of the mouse prion protein domain PrP(121-231)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Recombinant full-length murine prion protein, mPrP(23-231): purification and spectroscopic characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Lethal recessive myelin toxicity of prion protein lacking its central domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

A nine amino acid domain is essential for mutant prion protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Location and properties of metal-binding sites on the human prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Copper coordination in the full-length, recombinant prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

21 January 2018

1 reference

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Familial Creutzfeldt-Jakob disease with a five-repeat octapeptide insert mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Truncated forms of the human prion protein in normal brain and in prion diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

The N-terminal cleavage of cellular prion protein in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Cleavage of the amino terminus of the prion protein by reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Axonal prion protein is required for peripheral myelin maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Reactive oxygen species (ROS)-mediated beta-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Effects of post-translational modifications on prion protein aggregation and the propagation of scrapie-like characteristics in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

A potential mechanism for Cu2+ reduction, beta-cleavage, and beta-sheet initiation within the N-terminal domain of the prion protein: insights from density functional theory and molecular dynamics calculations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

The role of the octarepeat region in neuroprotective function of the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120031

21 January 2018

Identifiers

DOI

10.1042/BST20120031

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27 August 2017

1 reference