(Q38035234)

27 August 2017

title

Large-scale mouse knockouts and phenotypes (English)

1 reference

27 August 2017

Ramiro Ramírez-Solis

1

1 reference

27 August 2017

Edward Ryder

2

1 reference

27 August 2017

Richard Houghton

3

1 reference

27 August 2017

Jacqueline K White

4

1 reference

27 August 2017

Joanna Bottomley

5

1 reference

27 August 2017

language of work or name

1 reference

15 August 2012

1 reference

Wiley interdisciplinary reviews. Systems biology and medicine

27 August 2017

published in

1 reference

27 August 2017

volume

4

1 reference

27 August 2017

issue

6

1 reference

27 August 2017

page(s)

547-563

1 reference

Initial sequencing and comparative analysis of the mouse genome

27 August 2017

cites work

1 reference

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

21 January 2018

1 reference

Knockouts model the 100 best-selling drugs--will they model the next 100?

21 January 2018

1 reference

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

21 January 2018

1 reference

The new mouse genetics: altering the genome by gene targeting

21 January 2018

1 reference

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

21 January 2018

1 reference

Chromosome engineering in mice

21 January 2018

1 reference

From mice to men: insights into the insulin resistance syndromes

21 January 2018

1 reference

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

21 January 2018

1 reference

A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction

21 January 2018

1 reference

Mutagenic insertion and chromosome engineering resource (MICER).

21 January 2018

1 reference

The knockout mouse project

21 January 2018

1 reference

The European dimension for the mouse genome mutagenesis program

21 January 2018

1 reference

21 January 2018

A Mouse for All Reasons

1 reference

EUCOMM--the European conditional mouse mutagenesis program.

21 January 2018

1 reference

21 January 2018

1 reference

Systemic first-line phenotyping

21 January 2018

1 reference

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

21 January 2018

1 reference

Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

21 January 2018

1 reference

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource.

21 January 2018

1 reference

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

21 January 2018

1 reference

Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center

21 January 2018

1 reference

Removing the cloak of invisibility: phenotyping the mouse

21 January 2018

1 reference

Implementing large-scale ENU mutagenesis screens in North America

21 January 2018

1 reference

A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice

21 January 2018

1 reference

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

21 January 2018

1 reference

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

21 January 2018

1 reference

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

21 January 2018

1 reference

Capturing genes encoding membrane and secreted proteins important for mouse development

21 January 2018

1 reference

A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles

21 January 2018

1 reference

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

21 January 2018

1 reference

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

21 January 2018

1 reference

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

21 January 2018

1 reference

A recombineering based approach for high-throughput conditional knockout targeting vector construction

21 January 2018

1 reference

A highly efficient recombineering-based method for generating conditional knockout mutations

21 January 2018

1 reference

A conditional knockout resource for the genome-wide study of mouse gene function

21 January 2018

1 reference

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

21 January 2018

1 reference

Systematic identification of gene annotation errors in the widely used yeast mutation collections.

21 January 2018

1 reference

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126.

21 January 2018

1 reference

A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

21 January 2018

1 reference

Phenotypic annotation of the mouse X chromosome

21 January 2018

1 reference

Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice

21 January 2018

1 reference

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed

21 January 2018

1 reference

Producing fully ES cell-derived mice from eight-cell stage embryo injections

21 January 2018

1 reference

VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos

21 January 2018

1 reference

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

21 January 2018

1 reference

Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation.

21 January 2018

1 reference

Combination medium of cryoprotective agents containing L-glutamine and methyl-{beta}-cyclodextrin in a preincubation medium yields a high fertilization rate for cryopreserved C57BL/6J mouse sperm

21 January 2018

1 reference

Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells.

21 January 2018

1 reference

Optimized Cryopreservation of Mouse Sperm Based on Fertilization Rate

21 January 2018

1 reference

Inhibition of in vitro fertilizing capacity of cryopreserved mouse sperm by factors released by damaged sperm, and stimulation by glutathione

21 January 2018

1 reference

Simple and efficient in vitro fertilization with cryopreserved C57BL/6J mouse sperm

21 January 2018

1 reference

EMMA--mouse mutant resources for the international scientific community

21 January 2018

1 reference

A knockout mouse resource for the biomedical research community

21 January 2018

1 reference

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate

21 January 2018

1 reference

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

21 January 2018

1 reference

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation

21 January 2018

1 reference

21 January 2018

1 reference

A mouse knockout library for secreted and transmembrane proteins.

21 January 2018

1 reference

EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.

21 January 2018

1 reference

High-throughput mouse phenotyping

21 January 2018

1 reference

EuroPhenome: a repository for high-throughput mouse phenotyping data

21 January 2018

1 reference

Optimising experimental design for high-throughput phenotyping in mice: a case study

21 January 2018

1 reference

Power matters in closing the phenotyping gap.

21 January 2018

1 reference

Whole mount enzyme histochemistry as a rapid screen at necropsy for expression of beta-galactosidase (LacZ)-bearing transgenes: considerations for separating specific LacZ activity from nonspecific (endogenous) galactosidase activity.

21 January 2018

1 reference

Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program

21 January 2018

1 reference

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

21 January 2018

1 reference

microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos

21 January 2018

1 reference

Different data from different labs: lessons from studies of gene-environment interaction

21 January 2018

1 reference

Standardizing tests of mouse behavior: reasons, recommendations, and reality

21 January 2018

1 reference

Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies.

21 January 2018

1 reference

Ain't misbehavin' ? Genotype-environment interactions and the genetics of behavior

21 January 2018

1 reference

Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive

21 January 2018

1 reference

Housing, husbandry and handling of rodents for behavioral experiments

21 January 2018

1 reference

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

21 January 2018

1 reference

Is the obesity epidemic a national security issue around the globe?

21 January 2018

1 reference

Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic

21 January 2018

1 reference

Obesity and the metabolic syndrome: the stress on society

21 January 2018

1 reference

Validation and calibration of DEXA body composition in mice

21 January 2018

1 reference

Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals

21 January 2018

1 reference

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

21 January 2018

1 reference

Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception

21 January 2018

1 reference

Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice

21 January 2018

1 reference

Method for non-invasively recording electrocardiograms in conscious mice

21 January 2018

1 reference

Genetic influence on electrocardiogram time intervals and heart rate in aging mice

21 January 2018

1 reference

Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects

21 January 2018

1 reference

ENU induced mutations causing congenital cardiovascular anomalies

21 January 2018

1 reference

Ultrasound biomicroscopy in small animal research: applications in molecular and preclinical imaging.

21 January 2018

1 reference

High-throughput analysis of mouse embryos by magnetic resonance imaging

21 January 2018

1 reference

Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging.

21 January 2018

1 reference

Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining

21 January 2018

1 reference

Auditory brainstem responses in 10 inbred strains of mice

21 January 2018

1 reference

Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses

21 January 2018

1 reference

Overview of methods for assessing the mouse auditory system

21 January 2018

1 reference

BRCTx is a novel, highly conserved RAD18-interacting protein

21 January 2018

1 reference

Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice

21 January 2018

1 reference

The mouse genetics toolkit: revealing function and mechanism

21 January 2018

1 reference

The mammalian phenotype ontology: enabling robust annotation and comparative analysis

21 January 2018

1 reference

Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources

21 January 2018

1 reference

The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information

21 January 2018

1 reference

The human phenotype ontology.

21 January 2018

1 reference

Phenotype ontologies for mouse and man: bridging the semantic gap.

21 January 2018

1 reference

New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models

21 January 2018

1 reference

Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium

21 January 2018

1 reference

Neighboring-gene effect: a genetic uncertainty principle

21 January 2018

1 reference

Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes

21 January 2018

1 reference

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

21 January 2018

1 reference

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/WSBM.1183

1 reference

27 August 2017

1 reference