(Q38037989)

27 August 2017

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title

Drugs and receptors. An overview of the current state of knowledge (English)

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27 August 2017

Kenakin T

1

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27 August 2017

1 November 1990

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27 August 2017

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27 August 2017

40

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27 August 2017

5

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27 August 2017

666-687

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https://scigraph.springernature.com/pub.10.2165/00003495-199040050-00003

27 August 2017

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cites work

Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells

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12 December 2020

Receptor glycosylation regulates the affinity of histamine H1 receptors during smooth muscle cell differentiation

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12 December 2020

What do antagonists tell us about alpha-adrenoceptors?

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12 December 2020

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

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12 December 2020

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin

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12 December 2020

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence.

1 reference

12 December 2020

Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells

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12 December 2020

The differential loss of [3H]pirenzepine vs [3H] (-) quinuclidinylbenzilate binding to soluble rat brain muscarinic receptors indicates that pirenzepine binds to an allosteric state of the muscarinic receptor

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12 December 2020

Biochemical and immunological studies on the regulation of cardiac and neuronal muscarinic acetylcholine receptor number and function

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12 December 2020

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

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12 December 2020

Membrane effects of ethanol: bulk lipid versus lipid domains

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12 December 2020

Molecular biology of adrenergic and muscarinic cholinergic receptors. A perspective

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12 December 2020

Elevated membrane cholesterol concentrations inhibit glucagon-stimulated adenylate cyclase

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12 December 2020

Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea

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12 December 2020

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

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12 December 2020

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium

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12 December 2020

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

1 reference

12 December 2020

A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a Schild-plot with apparent slope unity. Agonist-dependent enantiomeric affinity ratios for bupranolol in tracheae but not in right atria of guinea pi

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12 December 2020

Alkanol effects on early potassium currents in Aplysia neurons depend on chain length

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12 December 2020

Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory

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12 December 2020

Permissive hormone regulation of hormone-sensitive effector systems

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12 December 2020

Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices

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12 December 2020

Some quantitative uses of drug antagonists

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12 December 2020

Actions of cholera toxin and the prevention and treatment of cholera

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12 December 2020

The interaction between D-2 dopamine receptors and GTP-binding proteins.

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12 December 2020

Histamine H1-receptor binding sites in guinea pig brain membranes: regulation of agonist interactions by guanine nucleotides and cations

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12 December 2020

Apparent loss of Gi protein activity in the diabetic retina

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12 December 2020

Location cloning strategy for characterizing genetic defects in Huntington's disease and Alzheimer's disease

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12 December 2020

Cloning of the cDNA for the human beta 1-adrenergic receptor

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12 December 2020

Catalytic unit of adenylate cyclase: reduced activity in aged-human lymphocytes

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12 December 2020

A simple method for displaying the hydropathic character of a protein

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12 December 2020

Myocardial aging: functional alterations and related cellular mechanisms

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12 December 2020

Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism

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12 December 2020

Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings

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12 December 2020

Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta

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12 December 2020

Challenges for receptor theory as a tool for drug and drug receptor classification

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12 December 2020

Identification of residues required for ligand binding to the beta-adrenergic receptor

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12 December 2020

Continuous variation of agonist affinity constants

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12 December 2020

Possible molecular basis for the pharmacokinetics and pharmacodynamics of three membrane-active drugs: propranolol, nimodipine and amiodarone

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12 December 2020

An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover

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12 December 2020

Activation of two signal-transduction systems in hepatocytes by glucagon

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12 December 2020

Carbachol depolarizes and accelerates pacemaker activity in the sinoatrial node of chicks treated with pertussis toxin

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12 December 2020

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

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12 December 2020

Effects of barbiturates and ethanol on the physical properties of brain membranes.

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12 December 2020

Pharmacological characterization of the postsynaptic alpha adrenoceptors in vascular smooth muscle from canine and rat mesenteric vascular beds.

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12 December 2020

Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes

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12 December 2020

Are receptors promiscuous? Intrinsic efficacy as a transduction phenomenon

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12 December 2020

The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin

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12 December 2020

Resultant pharmacological actions of verapamil: quantification of competitive 5-hydroxytryptamine antagonism in combination with calcium antagonism.

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12 December 2020

Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers

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12 December 2020

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit

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12 December 2020

Drug and tissue factors both confound KA measurements

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12 December 2020

On the Physiology of the Salivary Secretion: Part II. On the Mutual Antagonism of Atropin and Pilocarpin, having especial reference to their relations in the Sub-maxillary Gland of the Cat

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12 December 2020

Interactions between gallamine and muscarinic receptors: allosterism and subpopulation specificity are separate phenomena.

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12 December 2020

The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients

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12 December 2020

Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.

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12 December 2020

Analysis of competitive antagonism when this property occurs as part of a pharmacological resultant

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12 December 2020

Positive inotropic effects induced by carbachol in rat atria treated with islet-activating protein (IAP) - association with phosphatidylinositol breakdown

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12 December 2020

Receptor density and cAMP accumulation: analysis in CHO cells exhibiting stable expression of a cDNA that encodes the beta 2-adrenergic receptor

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12 December 2020

Multiple mechanisms of serotonergic signal transduction

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12 December 2020

Noncompetitive inhibitors reach their binding site in the acetylcholine receptor by two different paths

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12 December 2020

Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go).

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12 December 2020

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

1 reference

12 December 2020

Membrane-disordering action of ethanol: variation with membrane cholesterol content and depth of the spin label probe

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12 December 2020

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

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12 December 2020

Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors

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12 December 2020

Histamine H-1 binding site on human polymorphonuclear leukocytes

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12 December 2020

Physiological variation in alpha-adrenoceptor-mediated arterial sensitivity: relation to agonist affinity

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12 December 2020

Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site.

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12 December 2020

Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium

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12 December 2020

The Schild regression in the process of receptor classification

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12 December 2020

Measurement of antagonist affinity for purine receptors of drugs producing concomitant phosphodiesterase blockade: the use of pharmacologic resultant analysis.

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12 December 2020

Primary structure and biochemical properties of an M2 muscarinic receptor

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12 December 2020

Solubilization with digitonin alters the kinetics of pirenzepine binding to muscarinic receptors from rat forebrain and heart.

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12 December 2020

Errors in agonist affinity estimation: do they and should they occur in isolated tissue experiments?

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12 December 2020

Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core

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12 December 2020

Variable receptor affinity hypothesis

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12 December 2020

Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes.

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12 December 2020

Subsensitivity of the failing human heart to isoprenaline and milrinone is related to beta-adrenoceptor downregulation

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12 December 2020

Identification of receptor contact site involved in receptor-G protein coupling

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12 December 2020

Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs

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12 December 2020

Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity

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12 December 2020

Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle

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12 December 2020

Do pharmacological methods for the quantification of agonists work when the ternary complex mechanism operates?

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12 December 2020

Cross-dependence to opioid and alpha 2-adrenergic receptor agonists in NG108-15 cells

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12 December 2020

Myocardial beta-adrenergic receptor downregulation in heart failure

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12 December 2020

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12 December 2020

The classification of drugs and drug receptors in isolated tissues

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12 December 2020

Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein.

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12 December 2020

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes

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12 December 2020

Negative and positive inotropic responses to muscarinic agonists in guinea pig and rat atria in vitro

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12 December 2020

Pertussis toxin separates two muscarinic receptor-effector mechanisms in the striatum.

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12 December 2020

Variation in sensitivity of alpha adrenoceptor-mediated contraction of the vascular smooth muscle of rabbit elastic and muscular arteries is related to receptor affinity

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12 December 2020

Molecular properties of muscarinic receptors

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12 December 2020

Type-A cholecystokinin receptors in CHP212 neuroblastoma cells: evidence for association with G protein and activation of phosphoinositide hydrolysis

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12 December 2020

Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory

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12 December 2020

Solubilization and purification of the alpha 1-adrenergic receptor using a novel affinity resin

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12 December 2020

Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation

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12 December 2020

Pseudohypoparathyroidism: the molecular basis for hormone resistance--a retrospective.

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12 December 2020

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response

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12 December 2020

Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase

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12 December 2020

A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.

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12 December 2020

Transbilayer diffusion of phospholipids: dependence on headgroup structure and acyl chain length

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12 December 2020

A family of receptors coupled to guanine nucleotide regulatory proteins

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12 December 2020

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12 December 2020

Role of lipids in age-related changes in the properties of muscarinic receptors in cultured rat heart myocytes

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12 December 2020

Characterization of functional histamine H1 receptors on a cultured smooth muscle cell line

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12 December 2020

Prevention of the agonist binding to gamma-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex. Possible coupling of the toxin-sensitive GTP-binding proteins to receptors.

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12 December 2020

Membrane reconstitution of high-affinity alpha 2 adrenergic agonist binding with guanine nucleotide regulatory proteins

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12 December 2020

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease

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12 December 2020

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart

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12 December 2020

Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.

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12 December 2020

Muscarinic receptor subtypes in bovine adrenal medulla

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12 December 2020

Muscarinic receptor: multiple sites or unitary concept?

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12 December 2020

Continuous high density expression of human beta 2-adrenergic receptors in a mouse cell line previously lacking beta-receptors

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12 December 2020

Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

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12 December 2020

Development of pharmacological sensitivity to adenosine analogs in embryonic chick heart: role of A1 adenosine receptors and adenylyl cyclase inhibition.

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12 December 2020

Theoretical effects of single and multiple transducer receptor coupling proteins on estimates of the relative potency of agonists.

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12 December 2020

Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas

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12 December 2020

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

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12 December 2020

Lipid requirements for reconstitution of the delipidated beta-adrenergic receptor and the regulatory protein

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12 December 2020

The inhibitory effect of gallamine on muscarinic receptors

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12 December 2020

Precontraction-induced contractile response of isolated canine portal vein to alpha-2 adrenoceptor agonists

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12 December 2020

The quantification of relative efficacy of agonists

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12 December 2020

Specific desensitization of histamine H1 receptor-mediated [3H]glycogen hydrolysis in brain slices

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12 December 2020

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles

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12 December 2020

Classification of phenoxybenzamine/prazosin-resistant contractions of rat spleen to norepinephrine by Schild analysis: similarities and differences to postsynaptic alpha-2 adrenoceptors

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12 December 2020

Reduced β-adrenoceptor sensitivity in the elderly

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12 December 2020

Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site

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12 December 2020

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

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12 December 2020

Cerebral muscarinic acetylcholine receptors interact with three kinds of GTP-binding proteins in a reconstitution system of purified components

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12 December 2020

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor

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12 December 2020

Plasma norepinephrine in congestive heart failure

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12 December 2020

Choleragen, adenylate cyclase, and ADP-ribosylation

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12 December 2020

Demonstration of alpha 2-adrenoceptor-mediated contraction in the isolated canine saphenous artery treated with Bay K 8644

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12 December 2020

Presynaptic alpha 2-adrenoceptor, opioid kappa-receptor and adenosine A1-receptor interactions on noradrenaline release in rabbit brain cortex

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12 December 2020

Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: differentiation by agonists

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12 December 2020

Myocardial beta-adrenoceptor function and regulation in heart failure: implications for therapy

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12 December 2020

Cellular mechanisms of opioid tolerance: studies in single brain neurons

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12 December 2020

Insulin receptor: Interaction with nonreceptor glycoprotein from liver cell membranes

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12 December 2020

Effects of H2-receptor antagonists on 3H-cimetidine binding and histamine-stimulation of cellular cAMP in isolated guinea pig gastric glands

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12 December 2020

Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure-overload left ventricular failure

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12 December 2020

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

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12 December 2020

Pertussis toxin-sensitive guanine nucleotide-binding protein(S) couple adenosine A1 and 5-hydroxytryptamine1A receptors to the same effector systems in rat hippocampus: biochemical and electrophysiological studies

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12 December 2020

Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors

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12 December 2020

A modification of receptor theory

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12 December 2020

Modification of the binding properties of muscarinic receptors by gallamine

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12 December 2020

10.2165/00003495-199040050-00003

Identifiers

DOI

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PubMed ID

2292230

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

2292230