(Q38044298)

27 August 2017

DNA polymerases in nonhomologous end joining: are there any benefits to standing out from the crowd? (English)

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27 August 2017

Dale A Ramsden

1

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PubMed ID

22987211

27 August 2017

Kenjiro Asagoshi

series ordinal

2

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27 August 2017

18 September 2012

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Environmental and Molecular Mutagenesis

27 August 2017

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27 August 2017

53

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27 August 2017

9

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27 August 2017

741-751

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Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts

27 August 2017

1 reference

Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.

21 January 2018

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Two novel human and mouse DNA polymerases of the polX family

21 January 2018

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Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylation

21 January 2018

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Functions of DNA polymerases

21 January 2018

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The frameshift infidelity of human DNA polymerase lambda. Implications for function.

21 January 2018

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Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

21 January 2018

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Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo

21 January 2018

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Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotides

21 January 2018

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DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts

21 January 2018

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DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts

21 January 2018

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Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis

21 January 2018

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The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells

21 January 2018

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Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence

21 January 2018

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Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining

21 January 2018

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DNA joint dependence of pol X family polymerase action in nonhomologous end joining

21 January 2018

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End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining

21 January 2018

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Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase

21 January 2018

1 reference

Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine

21 January 2018

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Solution Structure of Polymerase μ's BRCT Domain Reveals an Element Essential for Its Role in Nonhomologous End Joining †

21 January 2018

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

21 January 2018

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DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

21 January 2018

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DNA polymerase lambda can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4-ligase IV complex

21 January 2018

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Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

21 January 2018

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A closed conformation for the Pol lambda catalytic cycle.

21 January 2018

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Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

21 January 2018

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Mice lacking TdT: mature animals with an immature lymphocyte repertoire

21 January 2018

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Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

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XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks

21 January 2018

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Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.

21 January 2018

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A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis

21 January 2018

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Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

21 January 2018

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Responding to DNA double strand breaks in the nervous system

21 January 2018

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BRCT domains: easy as one, two, three

21 January 2018

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DNA double-strand breaks: a potential causative factor for mammalian aging?

21 January 2018

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Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast.

21 January 2018

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Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair

21 January 2018

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A biochemically defined system for mammalian nonhomologous DNA end joining

21 January 2018

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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

21 January 2018

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Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination

21 January 2018

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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

21 January 2018

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The DNA-dependent protein kinase: the director at the end.

21 January 2018

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The X family portrait: structural insights into biological functions of X family polymerases.

21 January 2018

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Structural insight into the substrate specificity of DNA Polymerase mu

21 January 2018

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A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda.

21 January 2018

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Polymerase mu is a DNA-directed DNA/RNA polymerase

21 January 2018

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A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

21 January 2018

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

21 January 2018

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Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo

21 January 2018

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Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae.

21 January 2018

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DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship.

21 January 2018

1 reference

Structure and function of a mycobacterial NHEJ DNA repair polymerase

21 January 2018

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DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

21 January 2018

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Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

21 January 2018

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Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu.

21 January 2018

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Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region

21 January 2018

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The role of the non-homologous end-joining pathway in lymphocyte development

21 January 2018

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Lack of sugar discrimination by human Pol mu requires a single glycine residue

21 January 2018

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The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

21 January 2018

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DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage

21 January 2018

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Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends

21 January 2018

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Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells

21 January 2018

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Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ

21 January 2018

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A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining

21 January 2018

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Distribution and roles of X-family DNA polymerases in eukaryotes

21 January 2018

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Non-homologous end-joining, a sticky affair

21 January 2018

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Ionizing radiation sensitivity of DNA polymerase lambda-deficient cells

21 January 2018

1 reference

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway

21 January 2018

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The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

Highly frequent frameshift DNA synthesis by human DNA polymerase mu

21 January 2018

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Lesion bypass activities of human DNA polymerase mu.

21 January 2018

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Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.

21 January 2018

1 reference

Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide

21 January 2018

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8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

21 January 2018

1 reference

Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV

21 January 2018

1 reference

7 January 2021

Single-strand break repair and genetic disease

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7 January 2021

Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase

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7 January 2021

Non-homologous end joining dependency of gamma-irradiation-induced adaptive frameshift mutation formation in cell cycle-arrested yeast cells

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7 January 2021

Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

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7 January 2021

Identifiers

DOI

10.1002/EM.21725

1 reference

27 August 2017

1 reference

PubMed ID

22987211