(Q38066969)

28 August 2017

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title

Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (English)

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28 August 2017

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Jacob Thomas

1

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28 August 2017

Mark R Hutchinson

series ordinal

2

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28 August 2017

publication date

1 November 2012

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

28 August 2017

published in

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28 August 2017

volume

12

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28 August 2017

issue

11

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28 August 2017

page(s)

1311-1324

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The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

28 August 2017

cites work

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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

21 January 2018

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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

21 January 2018

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Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance

21 January 2018

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Morphine enhances microglial migration through modulation of P2X4 receptor signaling

21 January 2018

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Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

21 January 2018

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Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis

21 January 2018

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Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines.

21 January 2018

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Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia.

21 January 2018

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NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance

21 January 2018

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Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesia

21 January 2018

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Calcitonin gene-related peptide as a regulator of neuronal CaMKII-CREB, microglial p38-NFκB and astroglial ERK-Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia

21 January 2018

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Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

TNF alpha production in morphine-treated human neural cells is NF-kappaB-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Morphological evidence for the involvement of microglial p38 activation in CGRP-associated development of morphine antinociceptive tolerance

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Glia: novel counter-regulators of opioid analgesia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

Like cops on the beat: the active role of resting microglia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.12.125

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The tetrapartite synapse: path to CNS sensitization and chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Glial cells in neuronal network function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Neuroscience: Settling the great glia debate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Glia: the many ways to modulate synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

ATP and UTP activate calcium-mobilizing P2U-like receptors and act synergistically with interleukin-1 to stimulate prostaglandin E2 release from human rheumatoid synovial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The involvement of glial cells in the development of morphine tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

21 January 2018

Opiates and infection

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Pain management: is opioid immunosuppression a clinical problem?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nociception increases during opioid infusion in opioid receptor triple knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Morphine activates neuroinflammation in a manner parallel to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The distribution of receptors for the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in the developing human fetus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Tumor necrosis factor alpha increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Potent effect of interleukin-1 beta to evoke ATP and adenosine release from rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The function of microglia through purinergic receptors: neuropathic pain and cytokine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Chemokines in the CNS: plurifunctional mediators in diverse states

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

C and CX3C chemokines: cell sources and physiopathological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Morphine stimulates CCL2 production by human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Interactions between opioid and chemokine receptors: heterologous desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Release of cholecystokinin in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

New peptide in the vertebrate CNS reacting with antigastrin antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Evidence that disinhibition of brain stem neurones contributes to morphine analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Direct and indirect actions of morphine on medullary neurons that modulate nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Differential release of cholecystokinin by morphine in rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Current challenges in glia-pain biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

The role of mitogen-activated protein kinase (MAPK) in morphine tolerance and dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nitric oxide: first in a new class of neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nitric oxide (NO) and nociceptive processing in the spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Nitric oxide-proton stimulation of trigeminal ganglion neurons increases mitogen-activated protein kinase and phosphatase expression in neurons and satellite glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Regulation and functions of sphingosine kinases in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.12.125

21 January 2018

Identifiers

DOI

10.1586/ERN.12.125

1 reference

28 August 2017

1 reference