(Q38077215)

28 August 2017

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title

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling (English)

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28 August 2017

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Fei Yin

1

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28 August 2017

Tianyi Jiang

series ordinal

2

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28 August 2017

Enrique Cadenas

series ordinal

3

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28 August 2017

publication date

1 February 2013

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Biochemical Society Transactions

28 August 2017

published in

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28 August 2017

volume

41

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28 August 2017

issue

1

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28 August 2017

page(s)

101-105

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Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

28 August 2017

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1 reference

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Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

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21 January 2018

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Insulin signaling meets mitochondria in metabolism

21 January 2018

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 January 2018

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Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding

21 January 2018

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Insulin promotes glycogen storage and cell proliferation in primary human astrocytes

21 January 2018

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Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

21 January 2018

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PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

21 January 2018

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

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Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

21 January 2018

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

21 January 2018

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How mitochondria produce reactive oxygen species

21 January 2018

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Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons

21 January 2018

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Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes

21 January 2018

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Hydrogen peroxide as a signaling molecule

21 January 2018

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21 January 2018

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Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression

21 January 2018

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JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

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Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures

21 January 2018

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JNK activation is associated with intracellular beta-amyloid accumulation.

21 January 2018

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c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

21 January 2018

1 reference

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Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

21 January 2018

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An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

21 January 2018

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Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.

21 January 2018

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Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production

21 January 2018

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Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

21 January 2018

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

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Regulation of JNK signaling by GSTp

21 January 2018

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Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain

21 January 2018

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Insulin and JNK: optimizing metabolic homeostasis and lifespan

21 January 2018

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Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle

21 January 2018

1 reference

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

21 January 2018

1 reference

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Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

21 January 2018

1 reference

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Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120260

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120260

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120260

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

1 reference

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Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1042/BST20120260

1 reference

release_36zz6wfupvhgvdk5itvx4mzfda

28 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/36zz6wfupvhgvdk5itvx4mzfda

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://api.fatcat.wiki/v0/release/36zz6wfupvhgvdk5itvx4mzfda

mapped directly with Wikidata item

9 June 2023

based on heuristic

1 reference