(Q38089145)

28 August 2017

title

Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology (English)

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human embryonic stem cell

28 August 2017

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1 reference

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Jia-Qiang He

1

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28 August 2017

Craig T January

series ordinal

2

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28 August 2017

James A Thomson

series ordinal

3

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28 August 2017

Timothy J Kamp

series ordinal

4

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28 August 2017

language of work or name

English

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publication date

1 May 2007

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

2

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28 August 2017

issue

5

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28 August 2017

page(s)

739-753

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Establishment in culture of pluripotential cells from mouse embryos

28 August 2017

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Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

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Feeder layer- and serum-free culture of human embryonic stem cells

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Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

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Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium.

21 January 2018

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Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development.

21 January 2018

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Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers

21 January 2018

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Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.

21 January 2018

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Feeder-independent culture of human embryonic stem cells

21 January 2018

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Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions

21 January 2018

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Defined culture conditions of human embryonic stem cells

21 January 2018

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Stem cells: classifications, controversies, and clinical applications

21 January 2018

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Adult stem cell therapy for the heart

21 January 2018

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Cardiomyocyte differentiation from embryonic and adult stem cells

21 January 2018

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Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001.

21 January 2018

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Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

21 January 2018

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Homologous recombination in human embryonic stem cells.

21 January 2018

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Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types.

21 January 2018

1 reference

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Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

21 January 2018

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Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization

21 January 2018

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Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells

21 January 2018

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Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells

21 January 2018

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Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro

21 January 2018

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Mixed cultures of avian blastoderm cells and the quail mesoderm cell line QCE-6 provide evidence for the pluripotentiality of early mesoderm

21 January 2018

1 reference

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Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A.

21 January 2018

1 reference

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Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures

21 January 2018

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Differentiation of pluripotent embryonic stem cells into cardiomyocytes.

21 January 2018

1 reference

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Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis

21 January 2018

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Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development.

21 January 2018

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Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway

21 January 2018

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Identification of plateled-derived growth factor-BB as cardiogenesis-inducing factor in mouse embryonic stem cells under serum-free conditions

21 January 2018

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Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development

21 January 2018

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Generation of cardiomyocytes from embryonic stem cells experimental studies

21 January 2018

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Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells

21 January 2018

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Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes

21 January 2018

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Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells

21 January 2018

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Cardiac myocyte differentiation induced by 3,5,3'-triiodo-L-thyronine (T3) in P19 teratocarcinoma cells is accompanied by preferential binding of RGG(T/A)CA direct repeats spaced by 4 base pairs in the DNA.

21 January 2018

1 reference

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Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells

21 January 2018

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5-azacytidine induces cardiac differentiation of P19 embryonic stem cells.

21 January 2018

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Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes

21 January 2018

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Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes

21 January 2018

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Scalable production of embryonic stem cell-derived cardiomyocytes

21 January 2018

1 reference

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Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells

21 January 2018

1 reference

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Enhanced differentiation of human embryonic stem cells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment

21 January 2018

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In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells

21 January 2018

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Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

21 January 2018

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Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts

21 January 2018

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Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies

21 January 2018

1 reference

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Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Selection of ventricular-like cardiomyocytes from ES cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Potential applications of human embryonic stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Biology of cardiac arrhythmias: ion channel protein trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

QT Prolongation and Fatal Arrhythmias: A Review of Clinical Implications and Effects of Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Triggered activity in the heart: cellular mechanisms of early after-depolarizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Cellular mechanisms of early afterdepolarizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Mechanisms of ventricular arrhythmias in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Drug block of I(kr): model systems and relevance to human arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

The effect of extracellular matrix on embryonic stem cell-derived cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

Tissue engineering of a differentiated cardiac muscle construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.5.739

21 January 2018

Identifiers

DOI

10.1517/17460441.2.5.739

1 reference

28 August 2017

1 reference