(Q38096294)

28 August 2017

Protective and pathological roles of mast cells and basophils (English)

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28 August 2017

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David Voehringer

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28 August 2017

5 April 2013

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Nature Reviews Immunology

28 August 2017

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28 August 2017

13

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28 August 2017

362-375

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28 August 2017

5

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Novel identified receptors on mast cells

28 August 2017

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Regulation of mast cell responses in health and disease

31 March 2020

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Nonredundant roles of basophils in immunity.

31 March 2020

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The role of basophils in asthma

31 March 2020

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Our perception of the mast cell from Paul Ehrlich to now.

31 March 2020

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Mast cell-orchestrated immunity to pathogens

31 March 2020

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The role of mast cells in host defense and their subversion by bacterial pathogens

31 March 2020

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Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

31 March 2020

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Mast cells in the development of adaptive immune responses

31 March 2020

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The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity

31 March 2020

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New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation

31 March 2020

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Paul Ehrlich's doctoral thesis: a milestone in the study of mast cells

31 March 2020

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The Hemolymph of the ascidian Styela plicata (Chordata-Tunicata) contains heparin inside basophil-like cells and a unique sulfated galactoglucan in the plasma

31 March 2020

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Colocalization of heparin and histamine in the intracellular granules of test cells from the invertebrate Styela plicata (Chordata-Tunicata).

31 March 2020

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Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination

31 March 2020

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Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.

31 March 2020

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Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response

31 March 2020

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Identification of a committed precursor for the mast cell lineage.

31 March 2020

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Basophil effector function and homeostasis during helminth infection

31 March 2020

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The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

31 March 2020

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Identification of mast cell progenitors in adult mice

31 March 2020

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Distinguishing mast cell and granulocyte differentiation at the single-cell level

31 March 2020

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Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

31 March 2020

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Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

31 March 2020

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IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen

31 March 2020

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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

31 March 2020

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Critical role of P1-Runx1 in mouse basophil development.

31 March 2020

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Identification and characterization of undifferentiated mast cells in mouse bone marrow

31 March 2020

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Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages

31 March 2020

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The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis

31 March 2020

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Developmental origin and functional specialization of mast cell subsets

31 March 2020

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Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.

31 March 2020

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Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

31 March 2020

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IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

31 March 2020

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Stat5 expression is critical for mast cell development and survival

31 March 2020

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Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

31 March 2020

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Regulation of mast cell survival by IgE

31 March 2020

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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens

31 March 2020

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Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation

31 March 2020

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Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

31 March 2020

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Antibodies and IL-3 support helminth-induced basophil expansion.

31 March 2020

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New models for analyzing mast cell functions in vivo

31 March 2020

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Widespread immunological functions of mast cells: fact or fiction?

31 March 2020

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31 March 2020

Mast cells and company

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Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

31 March 2020

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Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness

31 March 2020

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Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

31 March 2020

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Vagaries of conditional gene targeting

31 March 2020

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Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner

31 March 2020

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Basophils are essential initiators of a novel type of chronic allergic inflammation

31 March 2020

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Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

31 March 2020

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Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

31 March 2020

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Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.

31 March 2020

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Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis.

31 March 2020

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MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

31 March 2020

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Basophils enhance immunological memory responses

31 March 2020

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How are T(H)2-type immune responses initiated and amplified?

31 March 2020

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Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation

31 March 2020

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Rat peritoneal mast cells present antigen to a PPD-specific T cell line

31 March 2020

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CD11c depletion severely disrupts Th2 induction and development in vivo

31 March 2020

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A mechanism for the initiation of allergen-induced T helper type 2 responses

31 March 2020

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Genetic analysis of basophil function in vivo.

31 March 2020

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The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.

31 March 2020

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Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity.

31 March 2020

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Basophils initiate IL-4 production during a memory T-dependent response

31 March 2020

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Basophils and the T helper 2 environment can promote the development of lupus nephritis

31 March 2020

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Basophils from humans with systemic lupus erythematosus do not express MHC-II

31 March 2020

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Basophils are not the key antigen-presenting cells in allergic patients

31 March 2020

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New paradigms in type 2 immunity

31 March 2020

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Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

31 March 2020

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Induction of human IgE synthesis in B cells by mast cells and basophils

31 March 2020

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Immune response potential of mast cell-deficient W/Wv mice

31 March 2020

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Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

31 March 2020

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Local IgE production in nasal allergy

31 March 2020

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Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm

31 March 2020

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The immune response to parasitic helminths: insights from murine models.

31 March 2020

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Diversity and dialogue in immunity to helminths.

31 March 2020

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Protective immune mechanisms in helminth infection

31 March 2020

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Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites

31 March 2020

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Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE.

31 March 2020

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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

31 March 2020

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IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

31 March 2020

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Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

31 March 2020

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B cells have distinct roles in host protection against different nematode parasites

31 March 2020

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Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.

31 March 2020

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Immunity-mediated regulation of fecundity in the nematode Heligmosomoides polygyrus--the potential role of mast cells

31 March 2020

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Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1.

31 March 2020

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Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection

31 March 2020

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IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis

31 March 2020

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Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

31 March 2020

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Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

31 March 2020

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Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo

31 March 2020

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To B or not to B: B cells and the Th2-type immune response to helminths

31 March 2020

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Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity

31 March 2020

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Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection

31 March 2020

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Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels

31 March 2020

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Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection.

31 March 2020

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Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals

31 March 2020

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IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections

31 March 2020

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Tick resistance: basophils in skin reactions of resistant guinea pigs.

31 March 2020

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31 March 2020

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Epidemiology of anaphylaxis in the United States

31 March 2020

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Active anaphylaxis in IgE-deficient mice

31 March 2020

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Anaphylaxis in mast cell-deficient mice

31 March 2020

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Mouse and human neutrophils induce anaphylaxis.

31 March 2020

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Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice

31 March 2020

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Peanuts can contribute to anaphylactic shock by activating complement.

31 March 2020

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Identification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthma

31 March 2020

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Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes

31 March 2020

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Mast cells can promote the development of multiple features of chronic asthma in mice

31 March 2020

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Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation

31 March 2020

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Basophil recruitment and activation in inflammatory skin diseases.

31 March 2020

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Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells

31 March 2020

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Mast cells in autoimmune disease

31 March 2020

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Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis

31 March 2020

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Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression

31 March 2020

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Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.

31 March 2020

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Mast cells: a cellular link between autoantibodies and inflammatory arthritis

31 March 2020

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Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis

31 March 2020

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RETRACTED: Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis

31 March 2020

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Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

31 March 2020

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Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation

31 March 2020

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Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution

31 March 2020

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Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution

31 March 2020

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Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns

31 March 2020

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Mast cell proteases: multifaceted regulators of inflammatory disease

31 March 2020

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Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells

31 March 2020

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Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis

31 March 2020

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Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

31 March 2020

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Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo

31 March 2020

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Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo

31 March 2020

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Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases

31 March 2020

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Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production

31 March 2020

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Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

31 March 2020

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Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.

31 March 2020

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Development, migration, and survival of mast cells

31 March 2020

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Mast cell transcription factors--regulators of cell fate and phenotype

31 March 2020

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Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).

31 March 2020

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

31 March 2020

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Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data

31 March 2020

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Mast cell-specific Cre/loxP-mediated recombination in vivo

31 March 2020

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Generation and characterization of alpha-chymase-Cre transgenic mice

31 March 2020

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Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs.

31 March 2020

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12 December 2020

Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family.

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12 December 2020

Cutaneous basophil responses and immune resistance of guinea pigs to ticks: passive transfer with peritoneal exudate cells or serum.

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12 December 2020

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

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12 December 2020

Differentiation of human basophils: an overview of recent advances and pending questions

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12 December 2020

Delayed expulsion of adult Trichinella spiralis by mast cell-deficient W/Wv mice

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12 December 2020

Naturally abundant basophils in the snapping turtle, Chelydra serpentina, possess cytophilic surface antibody with reaginic function

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12 December 2020

Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. IV. Analysis of the role of IgE antibodies and mast cells.

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12 December 2020

Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice

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12 December 2020

Basophils: new players in the cytokine network

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12 December 2020

Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology

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12 December 2020

Rejection of the intestinal parasite Nippostrongylus brasiliensis by mast cell-deficient W/Wv anemic mice

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12 December 2020

The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis

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12 December 2020

Production and life span of cutaneous mast cells in young rats

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12 December 2020

Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation

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12 December 2020

Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase

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12 December 2020

Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice

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12 December 2020

Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni

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12 December 2020

Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients

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12 December 2020

Acquired resistance to ticks. I. Passive transfer of resistance

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12 December 2020

Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks

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12 December 2020

Presence of mast cell precursors in peripheral blood of mice demonstrated by parabiosis

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12 December 2020

Identifiers

DOI

10.1038/NRI3427

1 reference

28 August 2017

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PubMed ID

23558889