(Q38098875)

28 August 2017

The ageing haematopoietic stem cell compartment (English)

1 reference

28 August 2017

Hartmut Geiger

1

1 reference

PubMed ID

23584423

28 August 2017

Gerald de Haan

series ordinal

2

1 reference

PubMed ID

23584423

28 August 2017

M Carolina Florian

series ordinal

3

1 reference

28 August 2017

15 April 2013

1 reference

Nature Reviews Immunology

28 August 2017

1 reference

28 August 2017

13

1 reference

28 August 2017

376-389

1 reference

28 August 2017

5

1 reference

Stems cells and the pathways to aging and cancer

28 August 2017

1 reference

Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

31 March 2020

1 reference

The aging of the immune system

31 March 2020

1 reference

Aging affects human B cell responses

31 March 2020

1 reference

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

31 March 2020

1 reference

31 March 2020

1 reference

Aging in the lympho-hematopoietic stem cell compartment

31 March 2020

1 reference

T cell development and receptor diversity during aging

31 March 2020

1 reference

Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

31 March 2020

1 reference

B-cell diversity decreases in old age and is correlated with poor health status

31 March 2020

1 reference

B cells and aging: molecules and mechanisms

31 March 2020

1 reference

31 March 2020

1 reference

Innate immunity in aging: impact on macrophage function

31 March 2020

1 reference

Inflamm-aging. An evolutionary perspective on immunosenescence

31 March 2020

1 reference

31 March 2020

1 reference

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential.

31 March 2020

1 reference

Cell intrinsic alterations underlie hematopoietic stem cell aging.

31 March 2020

1 reference

The aging of hematopoietic stem cells

31 March 2020

1 reference

Hematopoietic stem cell aging: wrinkles in stem cell potential

31 March 2020

1 reference

Stem cells and the aging hematopoietic system

31 March 2020

1 reference

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

31 March 2020

1 reference

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

31 March 2020

1 reference

Development and aging of primitive hematopoietic stem cells in BALB/cBy mice

31 March 2020

1 reference

Age-associated characteristics of murine hematopoietic stem cells

31 March 2020

1 reference

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

31 March 2020

1 reference

Aging of hematopoietic stem cells is regulated by the stem cell niche

31 March 2020

1 reference

The bone marrow at the crossroads of blood and immunity

31 March 2020

1 reference

Aging of the immune system as a prognostic factor for human longevity

31 March 2020

1 reference

31 March 2020

1 reference

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors

31 March 2020

1 reference

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

31 March 2020

1 reference

Clonal diversity of the stem cell compartment

31 March 2020

1 reference

Long-term propagation of distinct hematopoietic differentiation programs in vivo

31 March 2020

1 reference

Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs

31 March 2020

1 reference

Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness

31 March 2020

1 reference

Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

31 March 2020

1 reference

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

31 March 2020

1 reference

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

31 March 2020

1 reference

Aging of the microenvironment influences clonality in hematopoiesis

31 March 2020

1 reference

The hematopoietic stem cell in its place

31 March 2020

1 reference

Uncertainty in the niches that maintain haematopoietic stem cells

31 March 2020

1 reference

The haematopoietic stem cell niche at a glance.

31 March 2020

1 reference

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

31 March 2020

1 reference

Increased hematopoietic stem cell mobilization in aged mice

31 March 2020

1 reference

Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.

31 March 2020

1 reference

Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells

31 March 2020

1 reference

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation

31 March 2020

1 reference

Oxidative proteome modifications target specific cellular pathways during oxidative stress, cellular senescence and aging.

31 March 2020

1 reference

Somatic mitochondrial DNA mutations in mammalian aging

31 March 2020

1 reference

Premature ageing in mice expressing defective mitochondrial DNA polymerase

31 March 2020

1 reference

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

31 March 2020

1 reference

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

31 March 2020

1 reference

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

31 March 2020

1 reference

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

31 March 2020

1 reference

Association of FOXO3A variation with human longevity confirmed in German centenarians

31 March 2020

1 reference

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging

31 March 2020

1 reference

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

31 March 2020

1 reference

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

31 March 2020

1 reference

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

31 March 2020

1 reference

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

31 March 2020

1 reference

Telomeres, senescence, and hematopoietic stem cells

31 March 2020

1 reference

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

31 March 2020

1 reference

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

31 March 2020

1 reference

Influences of inbreeding and genetics on telomere length in mice

31 March 2020

1 reference

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.

31 March 2020

1 reference

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

31 March 2020

1 reference

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

31 March 2020

1 reference

DNA-damage-induced differentiation in hematopoietic stem cells.

31 March 2020

1 reference

Using mice to examine p53 functions in cancer, aging, and longevity

31 March 2020

1 reference

Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.

31 March 2020

1 reference

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

1 reference

Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

31 March 2020

1 reference

A review and appraisal of the DNA damage theory of ageing

31 March 2020

1 reference

DNA damage checkpoints in stem cells, ageing and cancer.

31 March 2020

1 reference

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

31 March 2020

1 reference

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.

31 March 2020

1 reference

Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites

31 March 2020

1 reference

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock

31 March 2020

1 reference

Immortal strands? Give me a break

31 March 2020

1 reference

Polycomb group proteins in hematopoietic stem cell aging and malignancies

31 March 2020

1 reference

Stem cells and cancer; the polycomb connection

31 March 2020

1 reference

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

31 March 2020

1 reference

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

31 March 2020

1 reference

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells

31 March 2020

1 reference

Dnmt3a is essential for hematopoietic stem cell differentiation

31 March 2020

1 reference

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

31 March 2020

1 reference

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells.

31 March 2020

1 reference

Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression

31 March 2020

1 reference

Epigenetic regulation of aging stem cells

31 March 2020

1 reference

Centrosome misorientation reduces stem cell division during ageing

31 March 2020

1 reference

Gene expression profiles associated with aging and mortality in humans

31 March 2020

1 reference

Concise review: polarity in stem cells, disease, and aging.

31 March 2020

1 reference

Polarity and differential inheritance--universal attributes of life?

31 March 2020

1 reference

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.

31 March 2020

1 reference

The stem-cell niche as an entity of action

31 March 2020

1 reference

Osteoblastic cells regulate the haematopoietic stem cell niche

31 March 2020

1 reference

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

31 March 2020

1 reference

Identification of the haematopoietic stem cell niche and control of the niche size

31 March 2020

1 reference

Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

31 March 2020

1 reference

Morphology, mechanisms and pathology of musculoskeletal ageing

31 March 2020

1 reference

Contribution of an aged microenvironment to aging-associated myeloproliferative disease

31 March 2020

1 reference

Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging

31 March 2020

1 reference

Hypoxic preconditioning enhances angiogenic potential of bone marrow cells with aging-related functional impairment.

31 March 2020

1 reference

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

31 March 2020

1 reference

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

31 March 2020

1 reference

Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function

31 March 2020

1 reference

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

31 March 2020

1 reference

Stem cells, ageing and the quest for immortality.

31 March 2020

1 reference

Therapeutic targeting of a stem cell niche

31 March 2020

1 reference

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

31 March 2020

1 reference

Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells

31 March 2020

1 reference

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

31 March 2020

1 reference

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

31 March 2020

1 reference

Restoring cell polarity: an HSC fountain of youth

31 March 2020

1 reference

31 March 2020

mTOR-what does it do?

1 reference

Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae

31 March 2020

1 reference

Cdc42--the centre of polarity

31 March 2020

1 reference

Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes

31 March 2020

1 reference

Rapamycin slows aging in mice

31 March 2020

1 reference

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

31 March 2020

1 reference

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

31 March 2020

1 reference

Extension of chronological life span in yeast by decreased TOR pathway signaling

31 March 2020

1 reference

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

31 March 2020

1 reference

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

31 March 2020

1 reference

Manifestations and mechanisms of stem cell aging.

31 March 2020

1 reference

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

31 March 2020

1 reference

Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.

31 March 2020

1 reference

The stem cell niche: tissue physiology at a single cell level

31 March 2020

1 reference

The hematopoietic stem cell niche.

31 March 2020

1 reference

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche

31 March 2020

1 reference

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche

31 March 2020

1 reference

Bone, microenvironment and hematopoiesis

31 March 2020

1 reference

Stability and flexibility of epigenetic gene regulation in mammalian development

31 March 2020

1 reference

Human DNA methylomes at base resolution show widespread epigenomic differences

31 March 2020

1 reference

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

31 March 2020

1 reference

Hot topics in epigenetic mechanisms of aging: 2011.

31 March 2020

1 reference

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

31 March 2020

1 reference

The great unravelling: chromatin as a modulator of the aging process

31 March 2020

1 reference

DNA damage, chromatin, and transcription: the trinity of aging

31 March 2020

1 reference

Purification and characterization of mouse hematopoietic stem cells

31 March 2020

1 reference

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

31 March 2020

1 reference

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

31 March 2020

1 reference

Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells

31 March 2020

1 reference

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

31 March 2020

1 reference

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

31 March 2020

1 reference

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

31 March 2020

1 reference

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.

31 March 2020

1 reference

Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

31 March 2020

1 reference

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

31 March 2020

1 reference

12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 reference

12 December 2020

Cdc42: a signal coordinator in hematopoietic stem cell maintenance

1 reference

12 December 2020

Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts

1 reference

12 December 2020

Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells

1 reference

12 December 2020

Deterministic regulation of hematopoietic stem cell self-renewal and differentiation.

1 reference

12 December 2020

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity.

1 reference

12 December 2020

The hematopoietic stem cell niche

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NRI3433

1 reference

28 August 2017

1 reference

PubMed ID

23584423