(Q38106623)

29 August 2017

title

Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms (English)

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29 August 2017

Neha Bhagwat

1

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29 August 2017

Ross L Levine

series ordinal

2

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29 August 2017

Priya Koppikar

series ordinal

3

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29 August 2017

publication date

14 May 2013

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International Journal of Hematology

29 August 2017

published in

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29 August 2017

volume

97

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29 August 2017

issue

6

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29 August 2017

page(s)

695-702

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

29 August 2017

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21 January 2018

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

21 January 2018

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Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

21 January 2018

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Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

21 January 2018

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Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms

21 January 2018

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Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor

21 January 2018

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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition

21 January 2018

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21 January 2018

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21 January 2018

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HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

21 January 2018

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Intrinsic resistance to JAK2 inhibition in myelofibrosis

21 January 2018

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Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells

21 January 2018

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Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells.

21 January 2018

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Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis.

21 January 2018

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Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells

21 January 2018

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21 January 2018

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21 January 2018

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Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.

21 January 2018

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21 January 2018

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TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients

21 January 2018

1 reference

12 December 2020

Some speculations on the myeloproliferative syndromes.

1 reference

12 December 2020

JAK protein tyrosine kinases: their role in cytokine signalling

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12 December 2020

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

1 reference

12 December 2020

JAK2, a third member of the JAK family of protein tyrosine kinases

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12 December 2020

A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms

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12 December 2020

A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis

1 reference

12 December 2020

10.1007/S12185-013-1353-5

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1052190754

0 references

1 reference