(Q38113172)

29 August 2017

title

Gelsolin: the tail of a molecular gymnast (English)

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29 August 2017

Shalini Nag

1

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29 August 2017

Mårten Larsson

series ordinal

2

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29 August 2017

Robert C Robinson

series ordinal

3

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29 August 2017

Leslie D Burtnick

series ordinal

4

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29 August 2017

language of work or name

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27 June 2013

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29 August 2017

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29 August 2017

volume

70

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29 August 2017

issue

7

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29 August 2017

page(s)

360-384

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Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions.

29 August 2017

cites work

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Villin expression is frequently lost in poorly differentiated colon cancer.

21 January 2018

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Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators.

21 January 2018

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Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity

21 January 2018

1 reference

Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin.

21 January 2018

1 reference

Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells

21 January 2018

1 reference

Gelsolin is a downstream effector of rac for fibroblast motility

21 January 2018

1 reference

Villin sequence and peptide map identify six homologous domains

21 January 2018

1 reference

Direct observation of actin filament severing by gelsolin and binding by gCap39 and CapZ

21 January 2018

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Supervillin couples myosin-dependent contractility to podosomes and enables their turnover

21 January 2018

1 reference

Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner

21 January 2018

1 reference

Definition of an N-terminal actin-binding domain and a C-terminal Ca2+ regulatory domain in human brevin

21 January 2018

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Inactivation of endotoxin by human plasma gelsolin.

21 January 2018

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Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components.

21 January 2018

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The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation

21 January 2018

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Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF

21 January 2018

1 reference

The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans

21 January 2018

1 reference

Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development

21 January 2018

1 reference

Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signaling

21 January 2018

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Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization

21 January 2018

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F-actin and myosin II binding domains in supervillin

21 January 2018

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The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex

21 January 2018

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Calcium ion exchange in crystalline gelsolin

21 January 2018

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The crystal structure of the C-terminus of adseverin reveals the actin-binding interface.

21 January 2018

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Multiple sequence alignment with hierarchical clustering

21 January 2018

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Bacterial invasion: a new strategy to dominate cytoskeleton plasticity

21 January 2018

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Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency

21 January 2018

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Modulation of gelsolin-induced actin-filament severing by caldesmon and tropomyosin and the effect of these proteins on the actin activation of myosin Mg(2+)-ATPase activity

21 January 2018

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Phosphatidylinositol 4,5-bisphosphate specifically stimulates PP60(c-src) catalyzed phosphorylation of gelsolin and related actin-binding proteins.

21 January 2018

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Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach

21 January 2018

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Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion

21 January 2018

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Modification of gelsolin with 4-fluoro-7-nitrobenz-2-oxa-1,3-diazole

21 January 2018

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Actin binding proteins: regulation of cytoskeletal microfilaments

21 January 2018

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Expression of various scinderin domains in chromaffin cells indicates that this protein acts as a molecular switch in the control of actin filament dynamics and exocytosis.

21 January 2018

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Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress

21 January 2018

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Beyond the epithelium: cadherin function in fibrous connective tissues

21 January 2018

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Supervillin-mediated suppression of p53 protein enhances cell survival

21 January 2018

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The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility

21 January 2018

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Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein

21 January 2018

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Topological assignment of the N-terminal extension of plasma gelsolin to the gelsolin surface

21 January 2018

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Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle

21 January 2018

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Visual insight into how low pH alone can induce actin-severing ability in gelsolin under calcium-free conditions

21 January 2018

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HELIQUEST: a web server to screen sequences with specific alpha-helical properties.

21 January 2018

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Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders

21 January 2018

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Villidin, a novel WD-repeat and villin-related protein from Dictyostelium, is associated with membranes and the cytoskeleton

21 January 2018

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PHOSIDA 2011: the posttranslational modification database

21 January 2018

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Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.

21 January 2018

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ESPript: analysis of multiple sequence alignments in PostScript

21 January 2018

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Gelsolin as a calcium-regulated actin filament-capping protein

21 January 2018

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Tropomyosin-based regulation of the actin cytoskeleton in time and space

21 January 2018

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Identification of proteins expressed differently among surgically resected stage I lung adenocarcinomas.

21 January 2018

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Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene

21 January 2018

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Tertiary structure of destrin and structural similarity between two actin-regulating protein families

21 January 2018

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Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation

21 January 2018

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Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

21 January 2018

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The Ca(2+)-induced conformational change of gelsolin is located in the carboxyl-terminal half of the molecule

21 January 2018

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Isolation of a domain of villin retaining calcium-dependent interaction with G-actin, but devoid of F-actin fragmenting activity

21 January 2018

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Conformational dynamics of actin: effectors and implications for biological function.

21 January 2018

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PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

21 January 2018

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The F-actin filament capping protein CapG is a bona fide nucleolar protein

21 January 2018

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The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle

21 January 2018

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From the first to the second domain of gelsolin: a common path on the surface of actin?1

21 January 2018

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Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line

21 January 2018

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Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.

21 January 2018

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Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton

21 January 2018

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SpliceMiner: a high-throughput database implementation of the NCBI Evidence Viewer for microarray splice variant analysis

21 January 2018

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Proteomic molecular portrait of interface zone in breast cancer

21 January 2018

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Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness

21 January 2018

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Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae.

21 January 2018

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Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type

21 January 2018

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Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex

21 January 2018

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Regulation of cell structure and function by actin-binding proteins: villin's perspective

21 January 2018

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Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma

21 January 2018

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Ca2+ regulation of gelsolin activity: binding and severing of F-actin

21 January 2018

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Structural analysis of gelsolin using synchrotron protein footprinting.

21 January 2018

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Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting

21 January 2018

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Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats

21 January 2018

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Equus caballus gelsolin--cDNA sequence and protein structural implications

21 January 2018

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Gelsolin Domains 4–6 in Active, Actin-free Conformation Identifies Sites of Regulatory Calcium Ions

21 January 2018

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Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair

21 January 2018

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Identification of a functional switch for actin severing by cytoskeletal proteins

21 January 2018

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Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

21 January 2018

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Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin

21 January 2018

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Functions of gelsolin: motility, signaling, apoptosis, cancer

21 January 2018

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Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

21 January 2018

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Identification of critical functional and regulatory domains in gelsolin

21 January 2018

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Co‐operation of domain‐binding and calcium‐binding sites in the activation of gelsolin

21 January 2018

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Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription

21 January 2018

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Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity

21 January 2018

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The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis

21 January 2018

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Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate.

21 January 2018

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Multifunctional roles of gelsolin in health and diseases

21 January 2018

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Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies

21 January 2018

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Refined structure of villin 14T and a detailed comparison with other actin-severing domains

21 January 2018

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Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function

21 January 2018

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Determination of the gelsolin binding site on F-actin: implications for severing and capping

21 January 2018

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The gelsolin family of actin regulatory proteins: modular structures, versatile functions.

21 January 2018

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Structure of gelsolin segment 1-actin complex and the mechanism of filament severing

21 January 2018

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The human actin-regulatory protein cap G: gene structure and chromosome location

21 January 2018

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Adseverin: a novel cisplatin-resistant marker in the human bladder cancer cell line HT1376 identified by quantitative proteomic analysis

21 January 2018

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Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration

21 January 2018

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Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma

21 January 2018

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Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

21 January 2018

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Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin

21 January 2018

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Regulation of chondrocyte differentiation by actin-severing protein adseverin

21 January 2018

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The nature of the globular- to fibrous-actin transition

21 January 2018

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Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton

21 January 2018

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gCap39 is a nuclear and cytoplasmic protein

21 January 2018

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Cell responses regulated by early reorganization of actin cytoskeleton

21 January 2018

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CapG −/− Mice Have Specific Host Defense Defects That Render Them More Susceptible than CapG +/+ Mice to Listeria monocytogenes Infection but Not to Salmonella enterica Serovar Typhimurium Infection

21 January 2018

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Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily

21 January 2018

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Molecular mechanisms controlling actin filament dynamics in nonmuscle cells

21 January 2018

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Localization of the calcium-sensitive actin monomer binding site in gelsolin to segment 4 and identification of calcium binding sites

21 January 2018

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Mass spectrometric characterization of gelsolin isoforms

21 January 2018

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Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1.

21 January 2018

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FancyGene: dynamic visualization of gene structures and protein domain architectures on genomic loci.

21 January 2018

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Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type

21 January 2018

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Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions

21 January 2018

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DOG 1.0: illustrator of protein domain structures

21 January 2018

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Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG.

21 January 2018

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Actin filament curvature biases branching direction

21 January 2018

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The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type).

21 January 2018

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Distribution of a gelsolin-like 74,000 mol. wt protein in neural and endocrine tissues

21 January 2018

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Severing of F-actin by the amino-terminal half of gelsolin suggests internal cooperativity in gelsolin

21 January 2018

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Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas

21 January 2018

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Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas

21 January 2018

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Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer

21 January 2018

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Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth

21 January 2018

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Gelsolin superfamily proteins: key regulators of cellular functions.

21 January 2018

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Fragmin60 encodes an actin-binding protein with a C2 domain and controls actin Thr-203 phosphorylation in Physarum plasmodia and sclerotia

21 January 2018

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Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

21 January 2018

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Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.

21 January 2018

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Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein

21 January 2018

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Effects of CapG overexpression on agonist-induced motility and second messenger generation.

21 January 2018

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Gelsolin, a multifunctional actin regulatory protein

21 January 2018

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Supervillin modulation of focal adhesions involving TRIP6/ZRP-1

21 January 2018

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Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery

21 January 2018

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Supervillin associates with androgen receptor and modulates its transcriptional activity

21 January 2018

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Pathways that control cortical F-actin dynamics during secretion

21 January 2018

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Regulation of cell motility by tyrosine phosphorylated villin

21 January 2018

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Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration

21 January 2018

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Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin

21 January 2018

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The structure of gelsolin bound to ATP.

21 January 2018

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Evidence for an actin binding helix in gelsolin segment 2; have homologous sequences in segments 1 and 2 of gelsolin evolved to divergent actin binding functions?

21 January 2018

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Villin-type headpiece domains show a wide range of F-actin-binding affinities.

21 January 2018

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Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin

21 January 2018

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Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration

21 January 2018

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A novel role for villin in intestinal epithelial cell survival and homeostasis

21 January 2018

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Helix Straightening as an Activation Mechanism in the Gelsolin Superfamily of Actin Regulatory Proteins

21 January 2018

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Jalview Version 2--a multiple sequence alignment editor and analysis workbench

21 January 2018

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Nucleotide sequence of pig plasma gelsolin

21 January 2018

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Expression of human plasma gelsolin in Escherichia coli and dissection of actin binding sites by segmental deletion mutagenesis

21 January 2018

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Are the conserved sequences in segment 1 of gelsolin important for binding actin?

21 January 2018

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Evidence for functional homology in the F-actin binding domains of gelsolin and alpha-actinin: implications for the requirements of severing and capping

21 January 2018

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Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

21 January 2018

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Phosphoinositide regulation of the actin cytoskeleton

21 January 2018

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Calcium-dependent conformational stability of modules 1 and 2 of human gelsolin

21 January 2018

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Two of the three actin-binding domains of gelsolin bind to the same subdomain of actin Implications for capping and severing mechanisms

21 January 2018

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Domain Movement in Gelsolin: A Calcium-Activated Switch

21 January 2018

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Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

21 January 2018

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Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

21 January 2018

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Flightless I deficiency enhances wound repair by increasing cell migration and proliferation

21 January 2018

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7 January 2021

Two low-affinity Ca(2+)-binding sites of gelsolin that regulate association with actin

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7 January 2021

Cysteine scanning mutagenesis at 40 of 76 positions in villin headpiece maps the F-actin binding site and structural features of the domain

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7 January 2021

The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons.

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7 January 2021

Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

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7 January 2021

Calcium-induced conformational changes in the C-terminal half of gelsolin stabilize its interaction with the actin monomer

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7 January 2021

Molecular biology of gelsolin, a calcium-regulated actin filament severing protein

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7 January 2021

The activation of gelsolin by low pH: the calcium latch is sensitive to calcium but not pH

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7 January 2021

Gelsolin binding to phosphatidylinositol 4,5-bisphosphate is modulated by calcium and pH

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7 January 2021

Tropomyosins regulate the impact of actin binding proteins on actin filaments.

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7 January 2021

Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis

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7 January 2021

A gelsolin-like Ca2+-dependent actin-binding domain in villin

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7 January 2021

Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin

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7 January 2021

Probing the effects of calcium on gelsolin

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7 January 2021

Cooperativity in F-actin: binding of gelsolin at the barbed end affects structure and dynamics of the whole filament

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7 January 2021

Control of actin filament length and turnover by actin depolymerizing factor (ADF/cofilin) in the presence of capping proteins and ARP2/3 complex

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7 January 2021

Calcium-induced conformational changes in the amino-terminal half of gelsolin

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7 January 2021

Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9

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7 January 2021

Actin-binding proteins are conserved from slime molds to man

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7 January 2021

Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.

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7 January 2021

Gelsolin and diseases.

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7 January 2021

Role of the basic C-terminal half of caldesmon in its regulation of F-actin: comparison between caldesmon and calponin

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7 January 2021

Fluorescent phosphoinositide derivatives reveal specific binding of gelsolin and other actin regulatory proteins to mixed lipid bilayers

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7 January 2021

Identification of the trapped calcium in the gelsolin segment 1-actin complex: implications for the role of calcium in the control of gelsolin activity

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7 January 2021

Identifiers

DOI

10.1002/CM.21117

1 reference

29 August 2017

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