(Q38123973)

29 August 2017

title

Endothelin 1 in cancer: biological implications and therapeutic opportunities (English)

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29 August 2017

Laura Rosanò

1

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29 August 2017

Francesca Spinella

series ordinal

2

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29 August 2017

Anna Bagnato

series ordinal

3

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29 August 2017

language of work or name

English

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publication date

25 July 2013

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29 August 2017

published in

Nature Reviews Cancer

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29 August 2017

volume

13

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29 August 2017

issue

9

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29 August 2017

page(s)

637-651

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The endothelin axis: emerging role in cancer

29 August 2017

cites work

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Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity

31 March 2020

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Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

31 March 2020

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Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells.

31 March 2020

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Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions.

31 March 2020

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β-Catenin activates the growth factor endothelin-1 in colon cancer cells

31 March 2020

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Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells

31 March 2020

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β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.

31 March 2020

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ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo

31 March 2020

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In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer

31 March 2020

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Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation

31 March 2020

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Endothelin-1 inhibits apoptosis in prostate cancer

31 March 2020

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Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells

31 March 2020

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Endothelin receptor A blockade enhances taxane effects in prostate cancer

31 March 2020

1 reference

Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer.

31 March 2020

1 reference

Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist

31 March 2020

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

31 March 2020

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Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes

31 March 2020

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Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways.

31 March 2020

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Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization.

31 March 2020

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Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.

31 March 2020

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Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression.

31 March 2020

1 reference

Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells

31 March 2020

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Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells

31 March 2020

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ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cells

31 March 2020

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UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells

31 March 2020

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Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells

31 March 2020

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Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells.

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

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Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells

31 March 2020

1 reference

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

31 March 2020

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Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells

31 March 2020

1 reference

Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells

31 March 2020

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Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer

31 March 2020

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Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells

31 March 2020

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Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers

31 March 2020

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Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture.

31 March 2020

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Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells.

31 March 2020

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Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells

31 March 2020

1 reference

Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma

31 March 2020

1 reference

RhoGDI2 is an invasion and metastasis suppressor gene in human cancer

31 March 2020

1 reference

Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer

31 March 2020

1 reference

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

31 March 2020

1 reference

Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

31 March 2020

1 reference

Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation

31 March 2020

1 reference

Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis.

31 March 2020

1 reference

Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury

31 March 2020

1 reference

Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain

31 March 2020

1 reference

Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice

31 March 2020

1 reference

Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade.

31 March 2020

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Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo.

31 March 2020

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Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells

31 March 2020

1 reference

Role of endothelin-1 in neovascularization of ovarian carcinoma

31 March 2020

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Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ

31 March 2020

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A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis

31 March 2020

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Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

31 March 2020

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Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells

31 March 2020

1 reference

Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1

31 March 2020

1 reference

Endothelins and hypoxia-inducible factor in cancer

31 March 2020

1 reference

Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells

31 March 2020

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Mesenchymal stem cells promote growth and angiogenesis of tumors in mice

31 March 2020

1 reference

Molecular classification of cutaneous malignant melanoma by gene expression profiling

31 March 2020

1 reference

Endothelin-1 stimulates colon cancer adjacent fibroblasts

31 March 2020

1 reference

Efficacy of the specific endothelin a receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study

31 March 2020

1 reference

Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2.

31 March 2020

1 reference

Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops.

31 March 2020

1 reference

Tumor immune surveillance and ovarian cancer: lessons on immune mediated tumor rejection or tolerance

31 March 2020

1 reference

Endothelin B receptor, a new target in cancer immune therapy.

31 March 2020

1 reference

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.

31 March 2020

1 reference

Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo

31 March 2020

1 reference

An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo

31 March 2020

1 reference

Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy

31 March 2020

1 reference

Modulation of human colon tumor-stromal interactions by the endothelin system.

31 March 2020

1 reference

Targeting the endothelin axis with atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma

31 March 2020

1 reference

Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods.

31 March 2020

1 reference

Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth

31 March 2020

1 reference

Role of the endothelin axis and its antagonists in the treatment of cancer

31 March 2020

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Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats

31 March 2020

1 reference

IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model

31 March 2020

1 reference

Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma

31 March 2020

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Endothelin-1 synthesis reduced by red wine

31 March 2020

1 reference

Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression

31 March 2020

1 reference

Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo

31 March 2020

1 reference

Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence.

31 March 2020

1 reference

Phase III, randomized, placebo-controlled study of once-daily oral zibotentan (ZD4054) in patients with non-metastatic castration-resistant prostate cancer

31 March 2020

1 reference

Detection of previously unidentified metastatic disease as a leading cause of screening failure in a phase III trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer

31 March 2020

1 reference

A Phase II, randomized, double-blind study of zibotentan (ZD4054) in combination with carboplatin/paclitaxel versus placebo in combination with carboplatin/paclitaxel in patients with advanced ovarian cancer sensitive to platinum-based chemotherapy

31 March 2020

1 reference

TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells.

31 March 2020

1 reference

Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells

31 March 2020

1 reference

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

31 March 2020

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A role for endothelin-2 and its receptors in breast tumor cell invasion

31 March 2020

1 reference

Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases

31 March 2020

1 reference

Endothelin-2 is upregulated in basal cell carcinoma under control of Hedgehog signaling pathway

31 March 2020

1 reference

NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche

31 March 2020

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Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

31 March 2020

1 reference

Endothelin-3 is produced by metastatic melanoma cells and promotes melanoma cell survival

31 March 2020

1 reference

Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role

31 March 2020

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Early progress in epigenetic regulation of endothelin pathway genes

31 March 2020

1 reference

Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer

31 March 2020

1 reference

Expression of the endothelin axis in noninvasive and superficially invasive bladder cancer: relation to clinicopathologic and molecular prognostic parameters

31 March 2020

1 reference

The endothelin system in human glioblastoma.

31 March 2020

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Functional endothelin ET B receptors are selectively expressed in human oligodendrogliomas.

31 March 2020

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Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer

31 March 2020

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Altered endothelin receptor subtypes in colorectal cancer

31 March 2020

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Expression patterns of endothelin-1 and its receptors in colorectal cancer

31 March 2020

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Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line

31 March 2020

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Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer

31 March 2020

1 reference

Polymorphisms in the endothelin-1 and endothelin a receptor genes and survival in patients with locoregionally advanced nasopharyngeal carcinoma

31 March 2020

1 reference

Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma

31 March 2020

1 reference

Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma.

31 March 2020

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Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival

31 March 2020

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Distinct patterns of endothelin axis expression in primary prostate cancer

31 March 2020

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Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan

31 March 2020

1 reference

CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.

31 March 2020

1 reference

Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma

31 March 2020

1 reference

A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma

31 March 2020

1 reference

Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone

31 March 2020

1 reference

A phase II, randomized, multicenter study to assess the efficacy, safety, and tolerability of zibotentan (ZD4054) in combination with pemetrexed in patients with advanced non-small cell lung cancer

31 March 2020

1 reference

Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer

31 March 2020

1 reference

A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer

31 March 2020

1 reference

A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma

31 March 2020

1 reference

A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy

31 March 2020

1 reference

Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan

31 March 2020

1 reference

12 December 2020

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

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12 December 2020

Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up

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12 December 2020

Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells

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12 December 2020

Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells

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12 December 2020

Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells

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12 December 2020

Expression and prognostic relevance of endothelin-B receptor in vulvar cancer

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12 December 2020

Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma.

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12 December 2020

Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model

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12 December 2020

Role of endothelin receptor signalling in squamous cell carcinoma

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12 December 2020

Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells

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12 December 2020

Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: a tissue microarray analysis

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12 December 2020

Expression of endothelin receptor subtypes in bronchial tumors

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12 December 2020

Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells

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12 December 2020

Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade

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12 December 2020

Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells

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12 December 2020

Identifiers

DOI

10.1038/NRC3546

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Dimensions Publication ID

29 August 2017

1035303163

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