(Q38151514)

29 August 2017

Dll4-Notch signaling in regulation of tumor angiogenesis (English)

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29 August 2017

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Zhaoguo Liu

1

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29 August 2017

Fangtian Fan

2

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29 August 2017

Aiyun Wang

3

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29 August 2017

Shizhong Zheng

4

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29 August 2017

Yin Lu

5

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29 August 2017

10 October 2013

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Journal of Cancer Research and Clinical Oncology

29 August 2017

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29 August 2017

140

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29 August 2017

4

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29 August 2017

525-536

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https://scigraph.springernature.com/pub.10.1007/s00432-013-1534-x

29 August 2017

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cites work

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

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Substrate specificity of gamma-secretase and other intramembrane proteases

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Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

21 January 2018

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

21 January 2018

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Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis

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Modes of resistance to anti-angiogenic therapy

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Notch signalling: a simple pathway becomes complex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch regulation of tumor angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

21 January 2018

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Periodic Delta-like 4 expression in developing retinal arteries.

21 January 2018

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The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling

21 January 2018

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Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

21 January 2018

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

21 January 2018

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The many facets of Notch ligands

21 January 2018

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Dosage-sensitive requirement for mouse Dll4 in artery development

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signaling regulates tumor angiogenesis by diverse mechanisms

21 January 2018

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Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy.

21 January 2018

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Dynamics of endothelial cell behavior in sprouting angiogenesis

21 January 2018

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Notch1 and notch2 have opposite effects on embryonal brain tumor growth

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

21 January 2018

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Tumor angiogenesis: therapeutic implications

21 January 2018

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A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

21 January 2018

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

21 January 2018

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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

21 January 2018

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Notch signaling in vascular development and physiology

21 January 2018

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Anti-DLL4, a cancer therapeutic with multiple mechanisms of action

21 January 2018

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Accessories to the crime: functions of cells recruited to the tumor microenvironment

21 January 2018

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Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

21 January 2018

1 reference

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

21 January 2018

1 reference

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Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

21 January 2018

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Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

21 January 2018

1 reference

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

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Notch signaling in blood vessels: who is talking to whom about what?

21 January 2018

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Therapeutic potential of gamma-secretase inhibitors and modulators

21 January 2018

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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

21 January 2018

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Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality

21 January 2018

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The role of notch in modeling and maintaining the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Interferon regulatory factor-1 (IRF-1) regulates VEGF-induced angiogenesis in HUVECs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signaling from tumor cells: a new mechanism of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Essential role of endothelial Notch1 in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Development of targeted angiogenic medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

CADASIL: a critical look at a Notch disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The angiogenic switch: implications in the regulation of tumor dormancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

New pathways and mechanisms regulating and responding to Delta-like ligand 4-Notch signalling in tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Angiogenesis: a team effort coordinated by notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Basic and therapeutic aspects of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Role of Notch signaling in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The history of the angiogenic switch concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Rational targeting of Notch signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Regulation of vascular morphogenesis by Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signaling in the hematopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Role of glycosylation of Notch in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signaling and Notch signaling modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Emerging role of Notch in stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Cross-talk between miRNA and Notch signaling pathways in tumor development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Notch signaling: emerging molecular targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-013-1534-X

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

21 January 2018

1 reference

12 December 2020

Jagged gives endothelial tip cells an edge

1 reference

12 December 2020

Notch: a key regulator of tumor angiogenesis and metastasis

1 reference

12 December 2020

The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions

1 reference

12 December 2020

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis.

1 reference

12 December 2020

Notch signaling in ocular vasculature development and diseases

1 reference

12 December 2020

Notch signaling is essential for vascular morphogenesis in mice

1 reference

12 December 2020

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma

1 reference

12 December 2020

10.1007/S00432-013-1534-X

Identifiers

DOI

1 reference

29 August 2017

1 reference