(Q38166972)

30 August 2017

title

PET probes for imaging brain acetylcholinesterase (English)

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30 August 2017

Tatsuya Kikuchi

1

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30 August 2017

Toshimitsu Okamura

series ordinal

2

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30 August 2017

Ming-Rong Zhang

series ordinal

3

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30 August 2017

Toshiaki Irie

series ordinal

4

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30 August 2017

publication date

1 March 2013

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Journal of Labelled Compounds and Radiopharmaceuticals

30 August 2017

published in

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30 August 2017

volume

56

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30 August 2017

issue

3-4

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30 August 2017

page(s)

172-179

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Changes in brain cholinesterases in senile dementia of Alzheimer type.

30 August 2017

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Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase

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In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP).

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Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase

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21 January 2018

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Evaluation of the binding characteristics of [5-(11)C-methoxy]Donepezil in the rat brain for in vivo visualization of acetylcholinesterase

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21 January 2018

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N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity

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Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET.

21 January 2018

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Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase? Studies on 18F-labeled G379.

21 January 2018

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Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease.

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PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD.

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PET study of brain acetylcholinesterase in cerebellar degenerative disorders

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Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine.

21 January 2018

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In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism.

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Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease.

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Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease

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In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease

21 January 2018

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Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease

21 January 2018

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Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET.

21 January 2018

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Acetylcholinesterase imaging: its use in therapy evaluation and drug design

21 January 2018

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Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders

21 January 2018

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Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment.

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Cholinergic dysfunction after traumatic brain injury: preliminary findings from a PET study.

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In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study

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Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET.

21 January 2018

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History of falls in Parkinson disease is associated with reduced cholinergic activity

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21 January 2018

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Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain

21 January 2018

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Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers.

21 January 2018

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Reactivity of 6-halopurine analogs with glutathione as a radiotracer for assessing function of multidrug resistance-associated protein 1.

21 January 2018

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PET imaging of MRP1 function in the living brain: method development and future perspectives

21 January 2018

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Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain

21 January 2018

1 reference

N-methylpiperidinemethyl, N-methylpyrrolidyl and N-methylpyrrolidinemethyl esters as PET radiotracers for acetylcholinesterase activity

21 January 2018

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Diacetoxypiperidinium analogs of acetylcholine

21 January 2018

1 reference

Effect of astrocytic energy metabolism depressant on 14C-acetate uptake in intact rat brain

21 January 2018

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Evaluation of [14C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain.

21 January 2018

1 reference

Improved synthesis and radiolabeling of [11C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET.

21 January 2018

1 reference

Syntheses of carbon-11 labeled piperidine esters as potential in vivo substrates for acetylcholinesterase

21 January 2018

1 reference

Quality control of PET radiopharmaceuticals using HPLC with electrochemical detection.

21 January 2018

1 reference

Development and validation of a liquid chromatographic method for the analysis of positron emission tomography radiopharmaceuticals with Ru(bpy)(3)(2+)-KMnO(4) chemiluminescence detection.

21 January 2018

1 reference

Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET.

21 January 2018

1 reference

Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys

21 January 2018

1 reference

Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis

21 January 2018

1 reference

Alpha-halogenic amines. XXIV. Preparation and properties of fluoromethyldialkylamines

21 January 2018

1 reference

Synthesis and preliminary evaluation of [18F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo

21 January 2018

1 reference

N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo

21 January 2018

1 reference

Evaluation of 18F-labeled acetylcholinesterase substrates as PET radiotracers.

21 January 2018

1 reference

A new and rapid colorimetric determination of acetylcholinesterase activity

21 January 2018

1 reference

Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples

21 January 2018

1 reference

Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay

21 January 2018

1 reference

Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.

21 January 2018

1 reference

Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase

21 January 2018

1 reference

Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

21 January 2018

1 reference

PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor

21 January 2018

1 reference

Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies

21 January 2018

1 reference

Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil

21 January 2018

1 reference

In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease

21 January 2018

1 reference

Positron emission tomography study of [11C]methyl-tetrahydroaminoacridine (methyl-tacrine) in baboon brain.

21 January 2018

1 reference

In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects.

21 January 2018

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Rat brain acetylcholinesterase visualized with [11C]physostigmine

21 January 2018

1 reference

Quantitative measurement of cerebral acetylcholinesterase using

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JLCR.3002

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30 August 2017

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