(Q38193362)

30 August 2017

1 reference

title

SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications (English)

1 reference

30 August 2017

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Hai-Feng Pan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Yan Liang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Wang-Dong Xu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Hui Peng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Dong-Qing Ye

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

0 references

publication date

27 March 2014

1 reference

European Journal of Immunology

30 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

1265-1275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

Suppressors of cytokine signalling: SOCS.

8 June 2020

cites work

1 reference

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21 January 2018

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The many faces of the SOCS box.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201344369

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3

21 January 2018

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Suppression of cytokine signaling: the SOCS perspective

21 January 2018

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

1 reference

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Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

21 January 2018

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Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions.

21 January 2018

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The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

21 January 2018

1 reference

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

1 reference

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

21 January 2018

1 reference

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

1 reference

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

21 January 2018

1 reference

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The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

21 January 2018

1 reference

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

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A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1).

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.

21 January 2018

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The SOCS box: a tale of destruction and degradation

21 January 2018

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Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

21 January 2018

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Regulatory Effect of SOCS on NF-κB Activity in Murine Monocytes/Macrophages

21 January 2018

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Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

21 January 2018

1 reference

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SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis

21 January 2018

1 reference

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A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo

21 January 2018

1 reference

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SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

21 January 2018

1 reference

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SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis

21 January 2018

1 reference

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Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

21 January 2018

1 reference

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The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.

21 January 2018

1 reference

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Constitutive phosphorylation of interferon receptor A-associated signaling proteins in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice

21 January 2018

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Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus

21 January 2018

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Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation

21 January 2018

1 reference

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Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice

21 January 2018

1 reference

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IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia

21 January 2018

1 reference

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Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

21 January 2018

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Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts

21 January 2018

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Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Deficient SOCS3 and SHP-1 expression in psoriatic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic ker

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

IFN-gamma induces apoptosis in developing mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

JAK's SOCS: a mechanism of inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

The expression of SOCS is altered in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201344369

7 January 2021

Identifiers

DOI

10.1002/EJI.201344369

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595859%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference